Department of Pharmaceutical Biology, Faculty of Pharmacy and Biotechnology,
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Vast numbers of unique noncoding RNA (ncRNA) molecules have been identified within different cellular compartments. Previous work has shifted the perception of ncRNAs from 'junk' transcriptional products to functional regulatory molecules. ncRNAs could potentially modulate different cellular processes including chromatin re-modeling, transcription, post-transcriptional modifications and most importantly signal transduction through having hundreds of targets that could simultaneously affect, thus nominating ncRNAs to play a key role in the process of carcinogenesis. In terms of oncology, the most abundant and well studied ncRNAs are the small ncRNA molecules known as microRNAs (miRNAs/miRs) and the long ncRNA (lncRNA) molecules. Such ncRNAs have been identified as either oncogenic drivers or tumor suppressors in different malignancies. Of note, ncRNAs have been recently involved in a bi-directional crosstalk between several oncogenic signaling cascades. Thus, a deeper understanding of the complex networks of interactions that ncRNAs could coordinate and are involved in would provide a unique opportunity to design better therapeutic interventions.
Aims and Scope:
Role of microRNAs in Solid Malignancies
Role of microRNAs in Hematological Malignancies
Role of long non-coding RNAs in Solid Malignancies
Role of long non-coding RNAs in Hematological Malignancies