Frontier Institute of Science and Techonogy, Xi'an Jiaotong University,
Guidelines for Submission
Manuscripts can be submitted until the expiry of the deadline. Submissions must be previously unpublished and may not be under consideration elsewhere.
Papers should be formatted according to the guidelines for authors (see: http://www.sciencepublishinggroup.com/journal/guideforauthors?journalid=219). By submitting your manuscripts to the special issue, you are acknowledging that you accept the rules established for publication of manuscripts, including agreement to pay the Article Processing Charges for the manuscripts. Manuscripts should be submitted electronically through the online manuscript submission system at http://www.sciencepublishinggroup.com/login. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal and will be listed together on the special issue website.
Imbalance between the production of reactive oxygen species (ROS) and the detoxification of their reactive intermediates by antioxidants causes oxidative stress. Cells must respond to this imbalance before the highly reactive molecules damage cellular structures, particularly DNA. Severe and prolonged oxidative stress can trigger apoptosis and necrosis. Numerous pathological conditions have an oxidative stress component, including cataract, leukemia, melanoma, renal failure, diabetes, cardiovascular diseases and neurodegenerative diseases such as Alzheimer. Signaling pathways downstream of ROS detection phosphorylate the transcription factor nuclear factor-erythroid 2-related factor 2 (Nrf2) which binds the antioxidant response element within the promoters of genes encoding antioxidant enzymes and detoxifying enzymes. Key Nrf2 target genes include antioxidants such as glutathione peroxidases (GPx) and genes involved in superoxide metabolism. These genes, in addition to some other antioxidants, reduce oxidative stress by breaking down ROS. Analysis of oxidants-antioxidants balance may yield new insights or new approach to how dealing with many diseases and cancer.
This special issue could serve as a background for the diseases which are due to oxidative stress and the role of antioxidants in scavenging the reactive oxygen species.