Study of the Cytotoxicity Effect of New Co(II) and Mn(II) Complexes of Flavon on Cancer (Cell Line RD) and Antimicrobial Activity
Journal of Cancer Treatment and Research
Volume 5, Issue 2, March 2017, Pages: 19-23
Received: Sep. 17, 2016; Accepted: Oct. 12, 2016; Published: Mar. 22, 2017
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Omar H. Al-Obaidi, Chemistry Department, Education College for Girls, Al-Anbar University, Ramadi, Iraq
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A new series of Co(II) and Mn(II) complexes with the Flavone ligand were studied on the growth of Rhabdomyo sarcomas (RD) cell Line in human by using in vitro system and compared with anticancer drug cisplatin (cis-pt) as appositive control. The cancer cells were treated with different concentration and cis-pt after 72 hr. exposure time. The cytotoxic activity was tested by inhibition rate as parameter. The results showed significant differences (p<0.05) for each three treatments when the inhibition rates were increased. The synthesized compounds were tested for antimicrobial activity by cup plate diffusion method. The results indicate the enhanced activity of metal complexes over the parent ligands.
Flavone, Complexes, Antimicrobial Activity, Cytotoxicity Cisplatin
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Omar H. Al-Obaidi, Study of the Cytotoxicity Effect of New Co(II) and Mn(II) Complexes of Flavon on Cancer (Cell Line RD) and Antimicrobial Activity, Journal of Cancer Treatment and Research. Vol. 5, No. 2, 2017, pp. 19-23. doi: 10.11648/j.jctr.20170502.14
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