Epidemiology of Celiac Disease in Children in Albania and Psychological Implications of the Disease
American Journal of Psychiatry and Neuroscience
Volume 5, Issue 6-1, November 2017, Pages: 57-57
Received: Oct. 10, 2017; Accepted: Oct. 12, 2017; Published: Oct. 13, 2017
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Authors
Ermira Dervishi, Department of Pediatrics, University Hospital Center “Mother Teresa”, Tirana, Albania
Aferdita Tako, Department of Pediatrics, University Hospital Center “Mother Teresa”, Tirana, Albania
Virtut Velmishi, Department of Pediatrics, University Hospital Center “Mother Teresa”, Tirana, Albania
Agim Gjikopulli, Department of Pediatrics, University Hospital Center “Mother Teresa”, Tirana, Albania
Sonila Tomori, Department of Pediatrics, University Hospital Center “Mother Teresa”, Tirana, Albania
Laurant Kollcaku, Department of Pediatrics, University Hospital Center “Mother Teresa”, Tirana, Albania
Paskal Cullufi, Department of Pediatrics, University Hospital Center “Mother Teresa”, Tirana, Albania
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Abstract
Aims: to describe the most recent data on the epidemiology of celiac disease in paediatric patients in Albania.
Method: 44 patients diagnosed with celiac disease (based on ESPHAGAN's criteria) during 2011-2013. The diagnosis was established using serological testing, level of tTG antibodies (IgA) as well as the degree of mucosal lesions through duodenal biopsy using endoscopy of upper gastro-intestinal tract. March classification was used to evaluate degree of histological changes in the small bowel.
Results and discussions: we had 26 girls and 16 boys, age interval 1-15 years, mean age for girls was 5,80 (1,1-13,8) and for boys was 6,09 (1,8-14,0). Symptoms presented were as follows: 38% had growth and developmental delays, 20% chronic diarrhoea, 11% abdominal pain, 7% vomiting, 4.5% anaemia, 3% abdominal distention, 2.2% chronic constipation, 2,2% irritability (asthenia) and 11% other symptoms. One in four patients had other associated disorders such as diabetes mellitus type 1 (n=4), genetic syndromes (n=2), autism spectrum disorders (n=2), hypothyreosis (n=1), IGF1 deficit (n=1). Mean value for tTG-IgA in girls was 137,8% (1,0-800) and in boys was 120,1 (2,0-369,). The histology of small bowel was consistent with March classification: T1-11,3% T2-18,18%, T3a- 20,4% T3b-9,0%, T3c-2,27%. The biopsy was not performed in 38.6% of entire sample. A positive correlation between morphological degree of changes and the level of tTG-IgA was found. High degree of March lesions was associated with high levels of antibodies tTG-IgA. All children were put in gluten-free diet. The follow up was done by evaluating weight, height, and level of tTG-IgA one year after being in gluten free diet.
Conclusions: Presentation with non-specific symptoms or a lack of symptoms is common and for early identification of celiac disease it is necessary serological testing in at risk groups.
Keywords
Celiac Disease, Children, Epidemiology
To cite this article
Ermira Dervishi, Aferdita Tako, Virtut Velmishi, Agim Gjikopulli, Sonila Tomori, Laurant Kollcaku, Paskal Cullufi, Epidemiology of Celiac Disease in Children in Albania and Psychological Implications of the Disease, American Journal of Psychiatry and Neuroscience. Special Issue: “In and out of Your Mind” Abstracts of 1st Eastern European Conference of Mental Health. Vol. 5, No. 6-1, 2017, pp. 57-57. doi: 10.11648/j.ajpn.s.2017050601.67
Copyright
Copyright © 2017 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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