Psychotropic Drugs and the Risk of Fracture in Old Age
American Journal of Psychiatry and Neuroscience
Volume 5, Issue 6-1, November 2017, Pages: 20-20
Received: Oct. 10, 2017; Accepted: Oct. 12, 2017; Published: Oct. 13, 2017
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Authors
Viorel Oltenacu, Department of Orthopaedics and Traumatology, “Sf. Ap. Andrei” Hospital, Galaţi, România
Paul Dan Sîrbu, Department of Orthopaedics and Traumatology, UMF Iasi, Romania
Razvan Tudor, Department of Orthopaedics and Traumatology, County Emergency Hospital, Vaslui, Roamania
Alexandru Bogdan Ciubară, Department of Morphological and Functional Sciences, Dunarea de Jos University, Galati, Romania
Roxana-Cristina Damaschin, Department of Orthopaedics and Traumatology, “Sf. Ap. Andrei” Hospital, Galaţi, România
Anamaria Ciubară, Department of Psychiatry, Dunarea de Jos University, Galati, Romania
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Abstract
Introduction Fractures in old age is a major health problem with considerable disability and mortality. Antipsychotic drugs (APs) have been associated with falls and fractures in elderly individuals.
Methods The study performed was a retrospective analysis with 97 participants. Subjects were everyone over the age of 65 with fractures radiologically confirmed, hospitalized in Department of Orthopaedics and Traumatology “Sf. Ap. Andrei” Galaţi, România, in May 2017. The objective was to evaluate the association between APs and the risk of fractures in elderly persons.
Results and discussion16 participants with confirmed fracture (16.50%) was associated with exposure to psychotropic medications. Those who took selective serotonin reuptake inhibitors (SSRIs), in particular, are linked to greater susceptibility to bone fractures: 10 out of 16 participants.
Conclusion The mechanism leading to this increased risk is unclear. Clinical studies examining causality or mechanisms of the observed association between antipsychotic drug use and excess risk of fractures are needed. Confounding by indication, other drugs used or comorbidity cannot be excluded, this association is relevant for clinical practice because fractures and antipsychotic drug use are prevalent in vulnerable older individuals.
Keywords
Psychotropic Drugs, Risk of Fractures, Edearly, Hip Fractures
To cite this article
Viorel Oltenacu, Paul Dan Sîrbu, Razvan Tudor, Alexandru Bogdan Ciubară, Roxana-Cristina Damaschin, Anamaria Ciubară, Psychotropic Drugs and the Risk of Fracture in Old Age, American Journal of Psychiatry and Neuroscience. Special Issue: “In and out of Your Mind” Abstracts of 1st Eastern European Conference of Mental Health. Vol. 5, No. 6-1, 2017, pp. 20-20. doi: 10.11648/j.ajpn.s.2017050601.30
Copyright
Copyright © 2017 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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