A Mini Review: Biological Significances of Nitrogen Hetero Atom Containing Heterocyclic Compounds
International Journal of Bioorganic Chemistry
Volume 2, Issue 3, September 2017, Pages: 146-152
Received: Feb. 16, 2017; Accepted: Mar. 18, 2017; Published: May 16, 2017
Views 1432      Downloads 138
Author
Mohammad Asif, Department of Pharmacy, Guru Ram Das (PG) Institute of Management and Technology, Dehradun, India
Article Tools
Follow on us
Abstract
Heterocycles have vital interest in the pharmaceuticals and agrochemicals. Synthetic chemistry provides wealth of heterocyclic systems. More than 90% of drugs contain heterocycles ring and the interface between chemistry and biology. Scientific insight, discovery and applications are taking place by heterocyclic compounds. This review article covers theactive heterocycles that have shown considerable biological actions such as antimicrobial, anti-inflammatory, analgesic, cardiovascular, neurological, antiallergic, herbicidal, and anticancer and various other useful activities.
Keywords
Heterocyclic Compounds, Biological Activities, Medicinal Drugs
To cite this article
Mohammad Asif, A Mini Review: Biological Significances of Nitrogen Hetero Atom Containing Heterocyclic Compounds, International Journal of Bioorganic Chemistry. Vol. 2, No. 3, 2017, pp. 146-152. doi: 10.11648/j.ijbc.20170203.20
Copyright
Copyright © 2017 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
References
[1]
Chen Q, Zhu X-L, Jiang L-L, Liu Z-M, Yang G-F. Synthesis, antifungal activity and CoMFA analysis of novel 1, 2, 4-triazolo [1, 5-a] pyrimidine derivatives. Eur J Med Chem, 2008, 43(3):595-603.
[2]
Amir M, Javed S. A, Harish K. Synthesis of some 1, 3, 4-oxadiazole derivatives as potential anti-inflammatory agents. Indian J. Chem, 2007, 46B: 1014-1019.
[3]
Trilok C, Neha G, Suman L, Saxena S. S. Synthesis of substituted acridinylpyrazoline derivatives and their evaluation for anti-inflammatory activity. Eur J. Med Chem, 2010, 45, 1772-1776.
[4]
Asif H, Ajmal M. Synthesis of novel 1, 3, 4-oxadiazole derivatives and their biologicalproperties. Acta Pharm. 2009, 59, 223-233.
[5]
Mymoona A, Asif H, Bismillah A, Aroylpropionic acid based 2, 5-disubstituted-1, 3, 4-oxadiazoles: Synthesis and their anti-inflammatory and analgesic activities. Eur J. Med Chem, 2009, 2372-2378.
[6]
Chao J-S, Huia P-X, Shuo L. Synthesis and Antibacterial Activities of Novel Biphenyl tetrazole Derivatives Bearing 1, 3, 4-Oxadiazole. J. Chinese Chem Soc, 2005, 52, 539-544 539.
[7]
Srinivas K, Srinivas U, Bhanuprakash K, Harakishore K. Synthesis and antibacterial activity of various substituted s-triazines. Eur J Med Chem,2006; 41: 1240-1246.
[8]
Mudasir B. R, Rayees M. H, Abdul R. Synthesis, characterization and anti-bacterial activity of 5-(alkenyl)-2-amino- and 2-(alkenyl)-5-phenyl-1,3,4-oxadiazoles. J. Chem. Sci, 2010, 122(2), 177–182.
[9]
Nanjunda S, Swamy S, Basppa, PriyaBs, Prabhuswamy B, Doreswamy BH. Crystal Structure of Novel2-butyl-4-chloro-1HImidazolyl-5-Carboxaldehyde. EurJ MedChem, 2006, 41: 531-538.3.
[10]
Hui X. P, Chu C. H, Zangzu, Wang Q, Zhang Q. Synthesis and antibacterial activity of 1, 3, 4-Thiadiazole derivatives of 5-amino, 2-hydroxybenzoic acid. Indian J. Chem, 2002, 41B: 2176.
[11]
Landreau C, Deniaud D, EvainM, Reliquet A. Efficient Regioselective Synthesis of Triheterocyclic Compounds: Imidazo[2, 1-b]benzothiazoles, Pyrimido[2, 1-b]-benzothiazolones and Pyrimido[2, 1-b]benzothiazoles. J. Chem Soc, Perkin Transactions,2002, 1(6), 741-745.
[12]
Gupta A, Rawat S. Synthesis and Cyclization of Benzothiazole: Review. J Curr Pharm Res, 2010, 3(1), 13-23.
[13]
El-Sherbeny M. A. Synthesis of Certain Pyrimido[2, 1-b]benzothiazole and Benzothiazolo [2, 3-b] quinazoline Derivatives for in vitro Antitumor and Antiviral Activities. Arzneimittel-Forschung Drug Res, 2000, 50(9), 848-853.
[14]
Chen, H. S, Li, Z. M, Li, J. F. Synthesis of 2-Pyrazoyl-5-substituted-1,3,4-oxadiazoles and Their Biological Activities. Chem. J. Chin. Univ. 2000, 21, 1520–1523.
[15]
Zhao, W. G, Chen, H. S, Li, Z. M, Han, Y. F, Yan, H, Lai, J. Y, Wang, S. H. Synthesis of Pyrazolyl heterocycles and Their Fungicidal Activities. Chin. J. Chem. 2001, 22, 939–942.
[16]
Zhao, W. G, Cao, Y. B, Li, Z. M, Gao, F. W, Wang, S. H, Wang, J. G. Synthesis and Biological Activity of 1-Sulfonyl-3, 5-diamino-1H-Pyrazole Derivatives. Chin. J. Appl. Chem. 2001, 18, 423–427.
[17]
Stanton H. L. K, R Gambari, Chung H. C, Johny C. O. T, Filly C, Albert S. C. C. Synthesis and anti-cancer activity of benzothiazole containing phthalimide on human carcinoma cell lines. Bioorg Med Chem, 2008, 16:3626-3631.
[18]
Wang M, Gao M, Mock B, Miller K, Sledge G, Hutchins G, Zheng Q. Synthesis of C-11 labelled fluorinated 2-aryl benzothiazoles as novel potential PET cancer imaging agent. Bioorg Med Chem, 2006; (14):8599-8607.
[19]
Chen J. J, Song B, Chen Z, Yang S. Synthesis, structure, and bioactivity of N0-substituted benzylidene-3, 4, 5-trimethoxybenzohydrazide and 3-acetyl-2-substituted phenyl-5-(3, 4, 5-tri-methoxyphenyl)-2, 3-dihydro-1, 3, 4-oxadiazole derivatives. Bioorg & Med Chem Lett, 2006, 16: 5036–504.
[20]
Ahmed A. S, Hamdy R-A. M, Nadia M. M. Novel 5-(2 hydroxyphenyl)-3-substituted-2, 3-dihydro-1, 3, 4-oxadiazole-2-thione derivatives: Promising anticancer agents. Bioorg & Med Chem,2006, 14: 1236–1246.
[21]
Sweetman S. P. The complete drug reference, 34th ed. London Pharmaceutical Press, 2004.
[22]
Baumann M, Baxendale I. R, Ley S. V, Nikbin N. Beil. J. Org. Chem. 2011, 7, 442-495.
ADDRESS
Science Publishing Group
1 Rockefeller Plaza,
10th and 11th Floors,
New York, NY 10020
U.S.A.
Tel: (001)347-983-5186