Ecofriendly Synthesis of Bioactive 2-thiobarbituric Acid Derivatives
International Journal of Bioorganic Chemistry
Volume 2, Issue 3, September 2017, Pages: 83-86
Received: Feb. 22, 2017; Accepted: Mar. 15, 2017; Published: Mar. 27, 2017
Views 1512      Downloads 142
M. A. Sattar, Department of Applied Chemistry and Chemical Engineering, Islamic University, Kushtia, Bangladesh
Mst. Khodeza Khatun, Department of Applied Chemistry and Chemical Engineering, Islamic University, Kushtia, Bangladesh
Tapan K. Sarkar, Department of Applied Chemistry and Chemical Engineering, Islamic University, Kushtia, Bangladesh
Sharif M. Al-Reza, Department of Applied Chemistry and Chemical Engineering, Islamic University, Kushtia, Bangladesh
Article Tools
Follow on us
In this study, five derivatives of 2-thiobarbituric acid were prepared under microwave irradiation (MWI) and conventional heating method. It was found that the preparation time wasreduced from 24 hours to 5-10 minutes by using microwave irradiation method. In microwave irradiation, the yield also comparatively very high (97.50-98.32%) than conventional method (74-78%). FT-IR, 1H-NMR spectral data were used to determine the structures of the compounds. The antimicrobial activity of the synthesized compounds were investigated by using Staphylococcus aureus, Bacillus megaterium, Escherichia coli and Pseudomonas aeruginosa bacteia. The zone of inhibition of the compounds were found in the range of 8 to 14 mm. In cytotoxic analysis, the mortality 74-89% were appeared when sample concentration were (0.78-6.25) μg/ml and more than 6.25 μg/ml concentration showed 100% mortality. The antimicrobial and cytotoxic activity of synthesized compoundswas found due to the presence of a reactive and unsaturated ketone.
Microwave Irradiation (MWI), 2-thiobarbituric Acid Derivatives, Arylidene Acetophenone, Antimicrobial and Cytotoxic Activity
To cite this article
M. A. Sattar, Mst. Khodeza Khatun, Tapan K. Sarkar, Sharif M. Al-Reza, Ecofriendly Synthesis of Bioactive 2-thiobarbituric Acid Derivatives, International Journal of Bioorganic Chemistry. Vol. 2, No. 3, 2017, pp. 83-86. doi: 10.11648/j.ijbc.20170203.11
Copyright © 2017 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License ( which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Patil, S.; Jadhav, S.; Patil, U. Arch. App. Sci. Res. 4 (2012) 1074.
Faida, H.; Bamanie, A.; Shehata, A. S.; Moustafa, M. A.; Mashaly, M. M. J. Am. Sci. 8 (2012) 481.
Sinha, T.; Ahmaruzzaman, M.; Bhattacharjee, A. Indian J. Chem. Tech. 23 (2016) 462.
Saeednia, S.; Ardakani, M. H.; Parizi, Z. P. et al. Transit. Met. Chem. 41 (2016) 767.
Calce, E.; Mercurio, F. A.; Leone, M.; Saviano, M.; De Luca, S. Carbohydrate Poly. 143 (2016) 84.
Patil, R.; Kumbhar, D.; Jadhav, S.; More, S.; Choudhari, P.; Bhatia, M.; Deshmukh, M. Int. J. Pharm. Sci. Rev. Res., 31 (2015) 1.
Prajapati, D.; Gohain, M. Beilstein J. Org. Chem. 2 (2006) 11.
Ren, Y. M.; Cai, C. Synth. Comm. 37 (2007) 2209.
Su, C.; Chen, Z. C.; Zheng, Q. G. Synthesis. 4 (2003) 555.
McCluskey, A. J.; Robinson, P.; Tim, H.; Janet, L.; Scott, C.; Edwards, A. K. Tetrahedron Lett. 43 (2002) 3117.
Kadoma, Y.; Fujisawa, S. Polymers. 4 (2012) 1025.
Sahu, D.; Ghosh, G.; Sahoo, J.; Sudhir, K. Int. J. Advan. Chem. Sci. Applications. 1 (2013) 25.
Gaber, H. M.; Abdel-Hafiz, I. S.; El-Sawy, K. M.; Sherif, S. M. Acta. Chim. Solv. 57 (2010) 230.
Zhi, H.; Chen, L.; Zhang, L.; Liu, S.; Cheong Wan, D. C.; Lin, H.; Chun, H. Arkivoc, 13 (2008) 266.
Vogel, A. I. A Text Book of Practical Organic Chemistry, 4th Edition, Longman Group Ltd., London, 1978; 796.
Veeriah, T.; Sondu, S. Indian J. Chem., 35 (1996) 1073.
Ahmed, M. G.; Romman, U. K. R.; Akhter, K.; Halim, M. E.; Rahman, M. M.; Ahmed, S. M. Indian J Chem. 5B (2011) 946.
Siddiqui, S. A.; Islam, R.; Islam, R.; Jamal, A. H. M.; Parvin, T.; Rahman, A. Arabian J Chem., 2013, In Press.
Al-Reza, S. M.; Rahman, A.; Lee, J.; Kang, S. C. Food Chem. 119 (2010) 981.
Balouiri, M.; Sadiki, M.; Ibnsouda, S. K. J. Pharmaceu. Analysis 6 (2016) 71.
Ali, Q.; Gulzar, A.; Hussain, A.; Asghar, A.; Bajwa, I. U. Sci. Int. (Lahore) 28 (2016) 407.
Habibi, A.; Tarameshloo, Z. J. Iranian Chem. Soc. 8 (2011) 287.
Hosseini, Y.; Rastgar, S.; Heren, Z.; Büyükgüngörc, O.; Pesyan, N. N. J. Chinese Chem. Soc. 58 (2011) 309.
Science Publishing Group
1 Rockefeller Plaza,
10th and 11th Floors,
New York, NY 10020
Tel: (001)347-983-5186