Design, Synthesis of New Amino Acid Derivatives and Evaluate DNA Binding Activity, Anticancer and Antimicrobial Activity
International Journal of Bioorganic Chemistry
Volume 2, Issue 2, June 2017, Pages: 36-50
Received: Dec. 23, 2016; Accepted: Jan. 10, 2017; Published: Mar. 2, 2017
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Ahmed A. Elhenawy, Chemistry Department, Faculty of Science, Al-Azhar University, Nasr City, Cairo, Egypt; Chemistry Department, Faculty of Science and Art, Al-Baha University, Al-Baha, Saudi Arabia
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Abstract
The present review covers the recent synthetic amino acid derivatives with chemical transformations to peptide derivatives. The amino acids were used as starting keys for synthesis peptides and pseudopeptides derived from pyridinine, coumarine, imaddizole, pyrazole phthalyl, qunolinine and sulfonamide rings. these biomolecules have diverse biological and pharmacological actions, as antimicrobial, anti-cancer targeting human carbonic anhydrase (CA) and DNA binding activities.
Keywords
Amino Acid, DNA Binding, Anticancer, Antimicrobial
To cite this article
Ahmed A. Elhenawy, Design, Synthesis of New Amino Acid Derivatives and Evaluate DNA Binding Activity, Anticancer and Antimicrobial Activity, International Journal of Bioorganic Chemistry. Vol. 2, No. 2, 2017, pp. 36-50. doi: 10.11648/j.ijbc.20170202.11
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Copyright © 2017 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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