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Thermoprotective Properties of the Venom of the Transcaucasian Vipera (Macrovipera Lebetina Obtusa Dyigubsky, 1832)
International Journal of Ecotoxicology and Ecobiology
Volume 2, Issue 3, September 2017, Pages: 98-101
Received: May 15, 2017; Accepted: Jun. 20, 2017; Published: Jul. 21, 2017
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Topchiyeva Shafiga, National Academy of Sciences of Azerbaijan, Baku, Azerbaijan
Babaev Elmar, National Academy of Sciences of Azerbaijan, Baku, Azerbaijan
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The paper presents data on the study of the thermoprotective properties of the venom of the Transcaucasian Vipeta (Macrovipera lebetina obtuse) on 120 white mongrel mice subjected to thermal exposure (30 - 50°C) for 30 minutes with the injection of zootoxin in doses (2 mg / kg and 4 mg / kg). It was found that the lifespan of mice was increased with respect to a series of experiments in which the injection of venoms under the conditions of normothermia was used for 28 - 30 minutes and 15 - 20 minutes to 120.0 ± 8.5 and 160.0 ± 19.7 minutes, respectively. It was found that in the posthyperthermic period after a 30-minute thermal exposure (30 - 50°C) in the control group of animal experiments, a 100% mortality was observed during 24 hours, and with the preliminary injection of a venom in the range of doses 2 - 4 mg / kg Survival in 30% - 50% of experimental animals was noted. Thus, the thermoprotective property of the venom of the Transcaucasian vipera has been proved.
Venom, Macrovipera Lebetina Obtusa, Thermoprotective Property, Mices, Zootoxins
To cite this article
Topchiyeva Shafiga, Babaev Elmar, Thermoprotective Properties of the Venom of the Transcaucasian Vipera (Macrovipera Lebetina Obtusa Dyigubsky, 1832), International Journal of Ecotoxicology and Ecobiology. Vol. 2, No. 3, 2017, pp. 98-101. doi: 10.11648/j.ijee.20170203.11
Copyright © 2017 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License ( which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Tuniyev, B. S., Ostrovskikh S. Two new species of vipers of “kaznakovi” complex (Ophidia, Viperinae) from the Western Caucasus. Russ. J. Herpetol. 2001, 8, 117–126.
Tuniyev, S. B., Orlov, N. L.,Tuniyev, B. S., Kidov F. F. On the taxonomical status of steppe viper from foothills of the south macroslope of the East Caucasus. Russ. J. Herpetol. 2013, 20, 129–146.
Abiyev H., Topchiyeva Sh. The study of the physical properties of Мacrovipera lebetina obtusа venom. Journal of Basic and Applied Scientific Research. 2013, 3 (11), 373-377.
Abiyev H. A., Babayev E. T., Topchiyeva Sh. A. The impact of environmental pollutants on viper venom Macrovipera lebetina obtusa. Journal of Entomology and Zoology Studies. 2016,4 (3), 378-381.
Ghazaryan N. A., Ghulikyan L., Kishmiryan A., Andreeva T. V., Utkin, Y. N., Tsetlin, V. I., Lomonte B., Ayvazyan N. M. Phospholipases A 2 from Viperidae snakes: Differences in membranotropic activity between enzymatically active toxin and its inactive isoforms. Biochim. Biophys. Acta. 2015, 1848, 463–468.
Vulfius, C. A., Kasheverov, I. E., Starkov, V. G., Osipov, A. V., Andreeva, T. V., Filkin, S. Y., Gorbacheva, E. V., Astashev, M. E., Tsetlin, V. I., Utkin, Y. N. Inhibition of nicotinic acetylcholine receptors, a novel facet in the pleiotropic activities of snake venom phospholipases A 2. PLoS ONE. 2014, 9.
Sergey I. Kovalchuk, Rustam H. Ziganshin, Vladislav G. Starkov, Victor I. Tsetlin and Yuri N. Utkin. Quantitative Proteomic Analysis of Venoms from Russian Vipers of Pelias Group: Phospholipases A 2 are the Main Venom Components. Toxins. 2016, 8,105.
Artishevsky A. A. Morphofunctional changes in the thyroid gland and adrenal glands in rat embryos under the influence of hyperthermia / A. A. Artishevsky, B. C. Gaiduk. 8 Congress of the Byelorussian, fiziol. Society for them. I. P. Pavlova. Tez. Doc. Minsk, 1994, 8-9.
Khomutov A. E., Yagin V. V. Bulletin of the University of Nizhny Novgorod. Series Biology. N. Novgorod, 2005. , 2 (10), 152-156.
Khomutov AE, Pursanov K. A., Danilova O. O. Actual problems of herpetology and toxicology. Issue. 9. Togliatti, 2006, 182-188.
Khomutov AE, Pursanov K. A., Danilova O. O. Bulletin of the Nizhny Novgorod State University. N.I. Lobachevsky. Morphological changes in rat lungs under the action of heparin and zootoxins under hyperthermia. 2007, b,112-115.
Khomutov AE, Lushnikova O. V. Posthyperthermal changes in rectal temperature and survival of rats against the background of the action of zootoxins. Bulletin of the Nizhny Novgorod State University. N. I. Lobachevsky, 2009, 5, 109-112.
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