Comparative Study on the Anti-Parasitic Activities of Securidaca and Senna occidentalis Root Extracts Against Trichomonas vaginalis
International Journal of Ecotoxicology and Ecobiology
Volume 2, Issue 1, March 2017, Pages: 45-51
Received: Sep. 26, 2016; Accepted: Oct. 13, 2016; Published: Mar. 1, 2017
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Imam T. S., Biological Sciences Department, Bayero University, Kano, Nigeria
Abdullahi M. M., Biological Sciences Department, Bayero University, Kano, Nigeria
Dabo. N. T., Biological Sciences Department, Bayero University, Kano, Nigeria
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Trichomonas vaginalis resistance to conventional antibiotics justifies the need to explore alternative remedies from medicinal plants since they represent a rich source of antiparasitic agents. This research was aimed to determine the inhibitory activities of two medicinal plants (S. longepedunculata and S. occidentalis) used to treat parasitic infections amongst the tribes of northern Nigeria. In the present study, extracts of the plants were obtained using maceration method, and their growth inhibitory activity against Trichomonas vaginalis evaluated in vitro. The extracts from the two plants revealed varied antiparasitic activities against the test organisms. The aqueous root extracts of the plants generally demonstrated higher growth inhibitory activity at 50 and 25mg/ml concentrations, while the least activity of the aqueous roots extracts were at lower concentration of 3.125mg/ml. The maximum antiparasitic activity was recorded for the aqueous root extract of S. synergistically against T. vaginalis. (Growth inhibition = 99.15%GI) at 50mg/ml. Findings from the statistical analysis, the result revealed significant difference (P<0.05) between S. and S. occidentalis. However, the result revealed significant difference (P<0.001), between the whole group of the aqueous root extracts with the negative control, and no significant difference among the other group of the aqueous roots extracts, The result presents the basis for which these plants have been used for treatment of Trichomonas vaginalis infections in traditional medicine. Results obtained suggest potential of the plants in the search for novel antiparasitic agents. Based on the findings from the current studies, the following suggestions are recommended: further researches should focus on other STI of medical importance such as Gonorrhea, Chlamydia, and Syphilis, and also research should be geared toward isolating active chemical component(s) and elucidate their exact mechanism(s) of action, safety margin and efficacy, Conservation of S. and S. occidentalis biodiversity should be also an important aspect to ensure sustainable availability of the plant.
Anti-parasitic Activities, S. longepedunculaat, S. occidentalis, T. vaginalis
To cite this article
Imam T. S., Abdullahi M. M., Dabo. N. T., Comparative Study on the Anti-Parasitic Activities of Securidaca and Senna occidentalis Root Extracts Against Trichomonas vaginalis, International Journal of Ecotoxicology and Ecobiology. Vol. 2, No. 1, 2017, pp. 45-51. doi: 10.11648/j.ijee.20170201.16
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