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Occupational Toxicological Characteristics of LLM-105 Explosives
International Journal of Ecotoxicology and Ecobiology
Volume 1, Issue 3, December 2016, Pages: 88-93
Received: Sep. 7, 2016; Accepted: Oct. 12, 2016; Published: Oct. 28, 2016
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Authors
Yu Weifei, Laboratory of Energetic Materials, Institute of Chemical Materials, China Academy of Engineering Physics, Mianyang, China
Liao Longyu, Laboratory of Energetic Materials, Institute of Chemical Materials, China Academy of Engineering Physics, Mianyang, China
Chen Feilan, Center of Experimental Animals, Chongqing Medical University, Chongqing, China
He Mingzhong, Center of Experimental Animals, Chongqing Medical University, Chongqing, China
Tan Dongmei, Center of Experimental Animals, Chongqing Medical University, Chongqing, China
Fan Guijuan, Laboratory of Energetic Materials, Institute of Chemical Materials, China Academy of Engineering Physics, Mianyang, China
Hao Shilong, Laboratory of Energetic Materials, Institute of Chemical Materials, China Academy of Engineering Physics, Mianyang, China
Lu Huanchang, Laboratory of Energetic Materials, Institute of Chemical Materials, China Academy of Engineering Physics, Mianyang, China
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Abstract
LLM-105, a novel nitro-substituted explosive, was evaluated for its occupational toxicological characteristics. Acute oral toxicity tests showed that the maximum tolerated dose should be 8% concentration (gastric irrigation 20mL/kg) and the minimum lethal dose should be 10% (gastric irrigation 20mL/kg). Acute dermal toxicity tests showed that LD50 should be more than 2000 mg/kg. Acute eye irritation tests showed that only slight irritations were found. Skin sensitization tests showed that slight allergic reactions were found. It was suggested that LLM-105 should be generally slightly toxic under normal process which should be positive as preliminary evaluation for occupational protection.
Keywords
2, 6-diamino-3, 5-dinitropyrazine-l-oxide (LLM-105), Toxicological Evaluations, Occupational Toxicological Characteristics
To cite this article
Yu Weifei, Liao Longyu, Chen Feilan, He Mingzhong, Tan Dongmei, Fan Guijuan, Hao Shilong, Lu Huanchang, Occupational Toxicological Characteristics of LLM-105 Explosives, International Journal of Ecotoxicology and Ecobiology. Vol. 1, No. 3, 2016, pp. 88-93. doi: 10.11648/j.ijee.20160103.15
Copyright
Copyright © 2016 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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