The Role of Long-Acting Antipsychotics in Patients Suffering a Schizophrenia and Comorbid Drug Use The Case of Paliperidone Palmitate
International Journal of Dual Diagnosis
Volume 2, Issue 1, March 2017, Pages: 8-12
Received: Feb. 28, 2017; Accepted: Mar. 4, 2017; Published: Mar. 21, 2017
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Núñez Domínguez L. A., Medical Center, Pamplona, Navarra, Spain
Barrado Los Arcos L., Mental Health Net, Pamplona, Navarra, Spain
Saiz García H., Mental Health Center, Pamplona, Navarra, Spain
López Olmo N., Psychiatric Hospital, Vitoria, País Vasco, Spain
Arbeo Ruiz O., Centro de Día Zuría, Pamplona, Navarra, Spain
García Nicolás M., Mental Health Center, Tudela, Navarra, Spain
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The psychopharmacological treatment of psychotic dual disorders is a real challenge for the clinicians, due to the low level of adherence to the treatment in many cases. For this reason, in some recent guides (Cochrane, Nice) it had been proposed the use of Long-term antipsychotic treatment (LAI-APS) as a way to improve the adherence and increase the efficacy of the treatment. Paliperidone Palmitate is one the most recent LAI-APS, with very good results in the treatment of psychotic disorder, with low number of drop-outs due to the good tolerability to these effects. The authors carry-out a preliminary study comparing the tolerability and efficacy of this LAI-APS in two samples of schizophrenic patients, one of them with comorbid drug use. Our results shows that the treatment permits in both groups the decrease of dosage and/or number of concomitant oral antipsychotic treatment, decrease the number of psychiatric admissions and the use of drug, with no drop-out during a period of one years, comparing with the previous year. We conclude that Paliperidone Palmitate could be a useful treatment in the group of patients suffering psychotic disorder with comorbid drug use.
Dual Disorders, Schizophrenia, Paliperidone Palmitate
To cite this article
Núñez Domínguez L. A., Barrado Los Arcos L., Saiz García H., López Olmo N., Arbeo Ruiz O., García Nicolás M., The Role of Long-Acting Antipsychotics in Patients Suffering a Schizophrenia and Comorbid Drug Use The Case of Paliperidone Palmitate, International Journal of Dual Diagnosis. Vol. 2, No. 1, 2017, pp. 8-12. doi: 10.11648/j.ijdd.20170201.12
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This article is an open access article distributed under the Creative Commons Attribution License ( which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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