Malaria Parasitaemia and Changes in Follicle Stimulating Hormone and Luteinizing Hormone Levels of Adult Mice
Advances in Applied Physiology
Volume 5, Issue 1, June 2020, Pages: 1-5
Received: Feb. 19, 2020;
Accepted: Mar. 26, 2020;
Published: Apr. 14, 2020
Views 191 Downloads 71
Naiho Alexander Obidike, Department of Human Physiology, Faculty of Basic Medical Sciences, College of Health Sciences, Delta State University, Abraka, Delta State, Nigeria
Ebite Lilian Ozokor, Department of Anatomy, Faculty of Basic Medical Sciences, College of Health Sciences, Delta State University, Abraka, Delta State, Nigeria
Ovuakporaye Simon Irikefe, Department of Human Physiology, Faculty of Basic Medical Sciences, College of Health Sciences, Delta State University, Abraka, Delta State, Nigeria
Gbagbeke Kelvin Obakore, Department of Human Physiology, Faculty of Basic Medical Sciences, College of Health Sciences, Delta State University, Abraka, Delta State, Nigeria
Kelechi Keneth Anachuna, Department of Human Physiology, Faculty of Basic Medical Sciences, College of Health Sciences, Delta State University, Abraka, Delta State, Nigeria
Follow on us
To understand the treatment of malaria, it is important to understand the effect of the administration of specific anti-malarials on various physiological variables. Current study investigated the effect (s) of the anti-malarial, coartem and co-administration of the antioxidant, Vitamin E on the levels of Luteinising and Follicle Stimulating Hormones [LH and FSH] of malaria parasite infected mice. Twenty-eight (28) adult mice were obtained, acclimatized for two (2) weeks and randomly selected into four (4) groups of seven (7) rats per group. Group 1 (Control) received standard mice diet and water ad libitum, while group 2 mice were infected with malaria (Plasmodium berghei) and left untreated. Groups 3 and 4 were inoculated with malaria (Plasmodium berghei); then treated with coartem and coartem + vitamin E respectively. After three (3) weeks of administration of test substance, the mice blood samples were obtained from mice (for each group) and assayed for serum FSH and LH levels. Statistical comparison was then conducted (using the student t-test) against those of control group to ascertain the effects of the changes due to coartem and/or antioxidant vitamin E co-administration to plasmodium berghei infected mice. Study found a statistically significant increase in serum LH levels of male mice after inoculation with plasmodium berghei. This decrease was noticed more even with coartem and antioxidant vitamin E co-administration, implicative of a possible effect in fecundity levels of infected male mice. The level of FSH was significantly increased in infected mice, but however showed a reversal following treatment with coartem and/or antioxidant vitamin E. The effects on reproductive hormones seen here may mirror the effects in man. More studies are needed to elucidate that.
Coartem, Leutinizing Hormone, Follicle Stimulating Hormone
To cite this article
Naiho Alexander Obidike,
Ebite Lilian Ozokor,
Ovuakporaye Simon Irikefe,
Gbagbeke Kelvin Obakore,
Kelechi Keneth Anachuna,
Malaria Parasitaemia and Changes in Follicle Stimulating Hormone and Luteinizing Hormone Levels of Adult Mice, Advances in Applied Physiology.
Vol. 5, No. 1,
2020, pp. 1-5.
Copyright © 2020 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/
) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Ricca F (2012). Social implication of malaria and their relationship with poverty. Mediterr J Haematol Infect Dis 4 (1).
Berman, J. (2001). The ears of the hippotamus; manifestations, determinants and estimate of the malaria burden. Am. J. Trop. Med. Hyg; 64 (1-2): 1-11.
World Health Organisation. World Malaria Report 2019. Geneva. 2019. www.who.int/malaria/publications/world-malaria-report-2019/en/.
Marshall, J. C (1975) Clinic in Endocrinol Metabolism. Investigative procedures clinc. Endocrimnol. Metab. 3: 545-567.
Boulpaep EL, Boron WF. Medical physiology: a cellular and molecular approach. Philadelphia, Saunders/elservier; 2005: 1319p.
Pitteloud N, Dwyer AA, DeCruz S, Lee H, Boepple PA, Crowley Jr WF, Hayes FJ. Inhibition of luteinizing hormone secretion by testosterone in men requires aromatization for its pituitary but not its hypothalamic effects: evidence from the tandem study of normal and gonadotropin-releasing hormone-deficient men. J Clin Endocrinol Metab 2008; 93 (7), 2686-92.
Davidson R, Brent A, Seale A. Oxford Handbook of Tropical Medicine. UK, Oxford University Press, 2014; 34-67.
World Health Organization (WHO) (2001). Antimalaria drugs combination therapy. Report of a WHO technical consultation. Document WHO/CDS/RBM/2001.35. Geneva.
Okanlawon AO, Ashiru OA. Sterological estimation of seminiferous tubules dysfunction in chloroquine treated rats. Afr J Med Sci 1998; 27: 101-106.
Raji Y, Akinsomisoye OS, Azeez MO. Impact of malaria parasite on reproductive indices of male mice. Reprod Med Biol 2006 sept; 5 (3): 201-210.
Raji Y, Osonuga IO, Akinsomisoye OS, Osonuga OA, Mewoyeka OO. Gonadotoxicity evaluation of oral artemisini derivative in male rats. J. Med Sci 2005; 5: 303-306.
Basir R, Fazalul Rahiman SS, Hasballah K, Chong WC, Talib H, Yam MF. Plasmodium berghei ANKA infection in ICR mice as a model of cerebral malaria. Iran J. Parasitol 2012; 7 (40): 62-74.
Samuel SA, Ayobami D, Jane AE. Comparative effects of commonly used artemisinin-based combination therapies (ACTs) on reproductive parameters in male wistar rats. MOJ Bioequiv Availab 2008; 5 (2): 122-128.
Adejuwon CA, Adejuwon AO. Serum steroids in mice infected with Plasmodium berghei berghei. J Med Sci 2005; 5 (3): 212-215.
Ojezele MO. Igbe I, Okhuarobo A. Reproductive indices in malaria infested mice treated with antimalarials, Phylanthus amarus combined with itamins. Bull Fac Pharm Cairo Univ 2018; 56 (2): 179-184.