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Diastolic Dysfunction and Its Implications to Serum Magnesium Changes in Hypertensives
Advances in Applied Physiology
Volume 4, Issue 1, June 2019, Pages: 5-10
Received: May 20, 2019; Accepted: Jun. 24, 2019; Published: Jul. 13, 2019
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Ekwere Ifeoma Toyin, College of Health Sciences, Delta State University, Abraka, Nigeria
Naiho Alexander Obidike, College of Health Sciences, Delta State University, Abraka, Nigeria
Ojieh Emeka Anthony, College of Health Sciences, Delta State University, Abraka, Nigeria
Odigie Mike Osagie, College of Health Sciences, Delta State University, Abraka, Nigeria
Ohwin Peggy Ejiro, College of Health Sciences, Delta State University, Abraka, Nigeria
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Overtime, Diastolic dysfunction (DD), which is seen in damping blood, and pressure build up within the ventricles has been associated with different disease states including chronic hypertension, coronary heart disease, aging, aortic stenosis, hypertrophic and restrictive cardiomyopathies. Diagnosis is by echocardiography (ECG) and often cumbersome. Howbeit, in acute stages of hypertension, prolongation of ventricular activation time in an ECG session has been described as potential marker for diagnosing DD. Current study was therefore undertaken to investigate ventricular activation time in essentially hypertensive Nigerians. One hundred and sixty two (162) hypertensives were recruited for the study. Their compliance to antihypertensive medication, blood pressure control, and electrocardiographic changes were determined and measured. Venous blood sample was then drawn and placed in special tubes to determine the serum magnesium concentrations, using a standard Colorimetric assay machine, Using the statistical measure of association (correlation), correlation between serum magnesium and ECG parameters was calculated using the Pearson’s correlation coefficient. One way analysis of variance (ANOVA) was also explored in obtaining differences in mean between variables. From our observations, only a weak correlation was found between serum magnesium levels and ECG findings across the study population. This proved statistically insignificant at p < 0.05. Other factors such as antihypertensive medications, duration of blood pressure and the control of blood pressure did not show any significant relationship.
Diastolic Dysfunction, Magnesium, Hypertension
To cite this article
Ekwere Ifeoma Toyin, Naiho Alexander Obidike, Ojieh Emeka Anthony, Odigie Mike Osagie, Ohwin Peggy Ejiro, Diastolic Dysfunction and Its Implications to Serum Magnesium Changes in Hypertensives, Advances in Applied Physiology. Vol. 4, No. 1, 2019, pp. 5-10. doi: 10.11648/j.aap.20190401.12
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Ganong WF (2005). Blood as a circulatory Fluid & the Dynamics of Blood & Lymph Flow. A Review of Medical Physiology. McGraw Hill, Boston. 22nd ed. 521-553.
Guyton, A. C. and Hall, J. E. (2006). Overview of the Circulation; Medical Physics of Pressure, Flow, and Resistance. Elsevier, philadephia. 11th ed. 832-839.
Lorell BH, Carabello BA (2000). Left Ventricular Hypertrophy-Pathogenesis, Detection, and Prognosis. Circulation; 102:470–479.
Sontia B, Touyz RM (2007). Role of magnesium in hypertension. Achieves of Biochemistry and Biophysics; 458 (1): 33-39.
Cunha A. R, Umbelino B, Correia ML, Neves MF (2012). Magnesium and Vascular Changes in Hypertension. International Journal of Hypertension; 1-7.
Lanier GM, Vaishnava P, Kosmas CE, Wagman G, Hiensch R, Vittorio TJ (2012). An update on diastolic dysfunction. Cardiology in Review; 20 (5): 230- 236.
Nagueh SF, Smiseth OA, Appleton CP, Byrd BF, Dokainish H, Edvardsen T (2016). Recommendations for the evaluation of left ventricular diastolic function by echocardiography: An update from the American society of echocardiography and the European association of cardiovascular imaging. European Heart Journal - Cardiovascular Imaging; 17 (12): 1321–1360.
Singh AS, Masuku MB (2014). Sampling Techniques and Determination of Sample Size in Applied Statistics Research: An Overview. International Journal of Economics, Commerce and Management; 2 (11): 1-22.
Touyz RM, Milne FJ (1999). Magnesium supplementation attenuates, but does not prevent, development of hypertension in spontaneously hypertensive rays. American Journal of Hypertension; 12 (8Pt 1): 757-65.
Boles U, Almuntaser I, Brown A, Murphy RR, Mahmud A, Feely J (2010). Ventricular activation time as a marker for diastolic dysfunction in early hypertension. Am J. Hypertens; 23 (7): 781-5.
Muzasti RA, Lubis HR (2015). Is blood magnesium level associated with total of antihypertensive drugs in chronic hemodialysis patient? Journal of Hypertension; 33: e28.
Odusan OO, Familoni OB, Odewabi AO, Idowu AO, Adekolade AS. Patterns and Correlates of Serum Magnesium Levels in Subsets of Type 2 Diabetes Mellitus Patients in Nigeria. Indian Journal of Endocrinology and Metabolism. 2017; 21 (3): 439–442.
Blaine J, Chonchol M, Levi M. Renal control of calcium, phosphate, and magnesium homeostasis. Clin J Am SocNephrol. 2015 Oct 7; 10 (10): 1886-7.
Chobanian AV, Bakris GL, Black HR, et al. The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report. JAMA. 2003 May 21. 289 (19): 2560-72.
Lameris AL, Monnens LA, Bindels RJ, Hoenderop JG (2012). Drug-induced alterations in Mg2+ homoeostasis. Clin Sci (Lond); 123 (1): 1-14.
Meijs MF, Bots ML, Vonken E. (2007). “Rationale and design of the SMART Heart study: A prediction model for lelf ventricular hypertrophy in hypertension”. Neth J. 15 (9): 295-8.
Oladapo O. O, Salako L, Sadiq L, Shoyinka K, Adedapo K, Falase AO. Target-organ damage and cardiovascular complications in hypertensive Nigerian Yoruba adults: a cross-sectional study. Cardiovasc J Afr. 2012 Aug; 23 (7): 379-84.
Adamu GU, Katibi AI, Opadijo GO, Omotoso AB, Araoye AM. Prevalence of left ventricular diastolic dysfunction in newly diagnosed Nigerians with systemic hypertension: a pulsed wave Doppler echocardiographic study. Afr Health Sci. 2010 Jun; 10 (2): 177-82.
Khan AM, Sullivan L, PhD, McCabe E, Levy D, Vasan RS, Wang TJ. Lack of association between serum magnesium and the risks of hypertension and cardiovascular disease. Am Heart J. 2010 Oct; 160 (4): 715–720.
Peacock JM, Folson AR, Arnett DK, Eckfelt JH, Szklo M (2011). Relationship of serum and dietary magnesium to incident hypertension: the Atherosclerosis Risk in Communities (ARIC) Study. Ann Epidemiol. Apr; 9 (3): 159-65.
Song Y, Sesso HD, Manson JE (2006). Dietary magnesium intake and risk of incident hypertension among middle-aged and older US women in a 10-year follow-up study. Am J Cardiol; 98: 1616–21.
Babatunde S L, Okechukwu OS, Adewole A A, Olulola OO (2009), Blood pressure control and left ventricular hypertrophy in hypertensive Nigerians annals of African medicine; 8: 156-162.
Oluseyi A, Adewole A (2018). A comparative and correlation study of electrocardiographic and echocardiographic left ventricular parameters in hypertension. Annals of African Medicine; 15 (1) 33-40.
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