Our Four Years Experience of Hemoadsorption, Albumin and Heparin Treatment for Paediatric Sepsis: Let’s Give a Chance in Multifactorial Pathological Conditions
American Journal of Pediatrics
Volume 6, Issue 3, September 2020, Pages: 207-217
Received: Mar. 3, 2020;
Accepted: Mar. 30, 2020;
Published: May 28, 2020
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Milella Leonardo, Pediatric Department of Anaesthesia and Intensive Care Unit (General and Post Cardiac Surgery), Giovanni XXIII Hospital - Policlinico di Bari, Bari, Italy
Cito Fabiana, Pediatric Department of Anaesthesia and Intensive Care Unit (General and Post Cardiac Surgery), Giovanni XXIII Hospital - Policlinico di Bari, Bari, Italy
Raimondo Pasquale, Department of Anaesthesia and Intensive Care (Cardiac Surgery Unit), Policlinico di Bari, Bari, Italy
Ficarella Maria Teresa, Pediatric Department of Anaesthesia and Intensive Care Unit (General and Post Cardiac Surgery), Giovanni XXIII Hospital - Policlinico di Bari, Bari, Italy
Moliterni Paola, Pediatric Department of Anaesthesia and Intensive Care Unit (General and Post Cardiac Surgery), Giovanni XXIII Hospital - Policlinico di Bari, Bari, Italy
Sisto Michele, Pediatric Department of Anaesthesia and Intensive Care Unit (General and Post Cardiac Surgery), Giovanni XXIII Hospital - Policlinico di Bari, Bari, Italy
Lasorella Maria Luigia, Pediatric Department of Anaesthesia and Intensive Care Unit (General and Post Cardiac Surgery), Giovanni XXIII Hospital - Policlinico di Bari, Bari, Italy
Lombardi Nadia, Department of Anaesthesia and Intensive Care, University of Foggia, OO RR, Foggia, Italy
Maldera Milena, Department of Anaesthesia and Intensive Care, School of Medicine - Milano Bicocca, Milano, Italy
Calabrese Gerolmina, Pediatric Department of Anaesthesia and Intensive Care Unit (General and Post Cardiac Surgery), Giovanni XXIII Hospital - Policlinico di Bari, Bari, Italy
Extracorporeal blood purification therapies are increasingly applied in the field of intensive care medicine. These techniques are applied to a relevant number of clinical situations as Sepsis, Trauma, burns, Influenza, surgery, Pancreatitis, ARDS, Life support, Liver failure. Compared to filtration-based methods mainly used for renal replacement therapy, newest adsorptive approaches have shown to specifically target the inflammatory cascade by the effective removal of relevant mediators. In the neonatal and pediatric setting however, the application of these methods brings with it various challenges but also profound technical difficulties. Recently, a promising extracorporeal device for cytokine adsorption (Cytosorb) has been introduced, however data for its application in critically ill pediatric patients remains sparse1. The lack of data and procedure protocols led us to take some aprioristic diagnostic and speculative decisions only from a scientific point of view: “in primis” when we decided for the first time in a pediatric patient to use this "Cytosorb Absorber", a device not registered and delivered for toddlers; second when it was clear that we could extend its use to not conventional disease therapeutic strategies; third when we decided to give to “Cytosorb” use the appellation and indication of “rescue treatment”. These results are interesting for the scientific community, but further research is needed.
Ficarella Maria Teresa,
Lasorella Maria Luigia,
Our Four Years Experience of Hemoadsorption, Albumin and Heparin Treatment for Paediatric Sepsis: Let’s Give a Chance in Multifactorial Pathological Conditions, American Journal of Pediatrics.
Vol. 6, No. 3,
2020, pp. 207-217.
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