Efficacy of Alendronic Acid/Colcalciferol Plus Calcium in the Treatment of Massive Osteolysis of Mandible
International Journal of Clinical Oral and Maxillofacial Surgery
Volume 1, Issue 1, June 2015, Pages: 1-3
Received: Jun. 3, 2015;
Accepted: Jun. 16, 2015;
Published: Jun. 17, 2015
Views 3723 Downloads 74
Emad T. Daif, Oral & Maxillofacial Surgery Department, Faculty of Oral & Dental Medicine, Cairo University, Maadi, Cairo, Egypt
Objectives: This study was carried out to evaluate the efficacy of alendronic acid / colcalciferol plus Calcium in management of edentulous patients with a severe bilateral resorption of the mandible. Materials and methods: Twenty edentulous patients with severely resorbed mandibles have been managed by alendronic acid / colcalciferol plus Calcium tablets. They were followed-up clinically and radiologically for one year. Results: The results were promising for nineteen patients (95%) where the radiographic density and height of the bone have been improved. However, the treatment was unsuccessful for one patient who was elder, 89 years old, than the others. Conclusions: On the basis of our findings, we encourage the use of alendronic acid / colcalciferol plus calcium in management of mandibular osteolysis particularly in young age.
Emad T. Daif,
Efficacy of Alendronic Acid/Colcalciferol Plus Calcium in the Treatment of Massive Osteolysis of Mandible, International Journal of Clinical Oral and Maxillofacial Surgery.
Vol. 1, No. 1,
2015, pp. 1-3.
Sharma A, Iyer N, Mittal A, Das D, Sharma S. Vanishing mandible. J Oral Sci 2010; 52:513-6.
Reddy S, Jatti D. Gorham's disease: a report of a case with mandibular involvement in a 10-year follow-up study. Dentomaxillofac Radiol 2012 ; 41:520-4.
Raghuveer HP, Jayalekshmy R. Gorham's massive osteolysis of the mandible – a progressive radiographic presentation. Dentomaxillofac Radiol 2009; 38:292-5.
Mignogna MD, Fedele S, Lo Russo L, Lanza A, Marenzi G, Sammartino G. Gorham's disease of the mandible mimicking periodontal disease on radiograph. J Clin Periodontol 2005; 32:1022-6.
Escande C, Schouman T, Françoise G, Haroche J, Ménard P, Piette JC, Bertrand JC, Ruhin-Poncet B. Histological features and management of a mandibular Gorham disease: a case report and review of maxillofacial cases in the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2008; 106:e30-7.
Bouloux GF, Walker DM, McKellar G. Massive osteolysis of the mandible: report of a case with multifocal bone loss. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1999; 87:357-61.
He J, He Y, Qiu W, Zhu H. Gorham disease in the maxilla. J Craniofac Surg 2012; 23:e293-5.
Kale MV, Gadre KS, Kulkarni AU. Progressive, massive osteolysis of mandible (Gorham's disease): report of a case. BMJ Case Rep 2012 8; 2012.
Möller G, Priemel M, Amling M, Werner M, Kuhlmey AS, Delling G. The Gorham-Stout syndrome (Gorham's massive osteolysis). A report of six cases with histopathological findings. J Bone Joint Surg Br 1999; 81:501-6.
Heffez L, Doku HC, Carter BL, Feeney JE. Perspectives on massive osteolysis. Report of a case and review of the literature. Oral Surg Oral Med Oral Pathol 1983; 55:331-43.
Devlin RD, Bone HG 3rd, Roodman GD. Interleukin-6: a potential mediator of the massive osteolysis in patients with Gorham-Stout disease. J Clin Endocrinol Metab 1996; 81:1893-7.
Takeda Y, Kuroda M, Suzuki A, Fujioka Y, Takayama K. Massive osteolysis of the mandible. Acta Pathol Jpn 1987; 37:677-84.
Mathias K, Hoffmann J, Martin K. [Gorham-Stout syndrome of the mandible]. Radiologe 1986; 26:439-41.
Deng R, Tang E, Lu M. Massive osteolysis of the mandible. J Craniofac Surg 2011; 22:2386-8.
Skidmore TB, Lee CM, Abbott TM, Wiggins RH 3rd, Anderson GE, Tward JD, Hitchcock Y. Gorham disease of the mandible: radiographic findings and radiotherapy response. Ear Nose Throat J 2008; 87:E4-7.
Paley MD, Lloyd CJ, Penfold CN. Total mandibular reconstruction for massive osteolysis of the mandible (Gorham-Stout syndrome). Br J Oral Maxillofac Surg 2005; 43:166-8.
Lopes N, Oliveira DM, Vajgel A, Pita I, Bezerra T, Vasconcellos RJ. A new approach for reconstruction of a severely atrophic mandible. J Oral maxillofac Surg 2009; 67:2455-9.
Melo LG, Almeida AL, Lopes JF, Rezende ML, Neto JS, Ciporkin F, Nagata MJ. A modified approach for vestibuloplasty in severely resorbed mandible using an implant-retained postoperative stent: a case report. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2008; 106:e7-14.
Huang Y, Wang L, Wen Y, Zhang Q, Li L. Progressively bilateral resorption of the mandible. J Craniomaxillofac Surg 2012; 40:e174-7.
Gondivkar SM, Gadbail AR. Gorham-Stout syndrome: a rare clinical entity and review of literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2010; 109:e41-8.
Avelar RL, Martins VB, Antunes AA, de Oliveira Neto PJ, Andrade ES. Use of zoledronic acid in the treatment of Gorham's disease. Int J Pediatr Otorhinolaryngol 2010; 74:319-22.
Mignogna MD, Fedele S, Lo Russo L, Ciccarelli R. Treatment of Gorham's disease with zoledronic acid. Oral Oncol 2005; 41:747-50.