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Bioactive Constituents of Essential Oil from Khaya senegalensis (Desr.) Bark Extracts
American Journal of Chemical and Biochemical Engineering
Volume 2, Issue 2, December 2018, Pages: 50-54
Received: Nov. 15, 2018; Accepted: Dec. 13, 2018; Published: Jan. 22, 2019
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Blessing Ikoojo Omotoyinbo, Department of General Studies, Chemistry Unit, Federal College of Agriculture, Akure, Nigeria
Ayoola Ebenezer Afe, Department of Biochemistry, Federal University of Technology, Akure, Nigeria
Olawale Solomon Kolapo, Department of General Studies, Chemistry Unit, Federal College of Agriculture, Akure, Nigeria
Oluseyi Valerie Alagbe, Department of General Studies, Chemistry Unit, Federal College of Agriculture, Akure, Nigeria
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The use of plants in traditional medicines has been a common practice in the medical care of many human cultures and dates back to several thousands of years and pre-dates the introduction of antibiotics and other related drugs due to their great source of phytochemicals which are exploited in all medical systems. These study was aimed at characterizing using Gas Chromatography-Mass Spectrometry (GC/MS) technique, the chemical constituents of the essential oil extracted from the bark of Khaya senegalensis Desr. using methanol-chloroform. Eight compounds were identified which include: Sulfurous acid, decylpentyl ester (0.51%), n-Hexadecanoic acid (12.08%), 1-Pentadecanol (1.84%), 13,16-Octadecadienoic acid, methyl ester (1.71%), Oleic acid (39.16%), Octadecanoic acid (21.9%), Dodecanoyl chloride (3.93%) and cis-11-hexadecenal (18.88%). The presence of these compounds in the the bark of Khaya senegalensis might amongst many other bioactive constituents are responsible for the medicinal properties these plant part exhibits and is been used for in herbal medicines.
Khaya senegalensis, GC/MS Analysis, Essential Oil, Traditional Medicine
To cite this article
Blessing Ikoojo Omotoyinbo, Ayoola Ebenezer Afe, Olawale Solomon Kolapo, Oluseyi Valerie Alagbe, Bioactive Constituents of Essential Oil from Khaya senegalensis (Desr.) Bark Extracts, American Journal of Chemical and Biochemical Engineering. Vol. 2, No. 2, 2018, pp. 50-54. doi: 10.11648/j.ajcbe.20180202.13
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Dar RA, Shahnawaz M, Qazi PH (2017). General overview of Medicinal Plants: A review. The Journal of Phytopharmacology, 6(6): 349-351.
Abdelouaheb D, Amadou D (2012). The Therapeutic Benefits of Essential Oils, Nutrition, Well Being and Health, Dr. JaouadBouayed (Ed.), ISBN: 978-953-51-0125-3.
Ademola IO, Fagbemi BO, Idowu SO (2004). Evaluation of the anthelmintic activity of Khaya senegalensis extract against gastrointestinal nematodes of sheep: invitro and in vivo studies. Vet Parasitol;122:151-64.
Androulakis XM, Muga SJ, Chen F, Koita Y, Toure B, Wargovich MJ (2006). Chemoprotective effects of Khayasenegalensisbark extract on human colorectal cancer. Anticancer Researc; 26(3B):2397-406.
Dutta S, Chatterjee S, Chatterjee S (2012). Overview on the ethnophytopathological studies of Cassia alata- an important medicinal plant and the effect of VAM on its growth and productivity. International journal of research in botany; 2(4):13-19.
Full AB, Vanhaelen-Fester R, Valenhaelen M, Lo I, Toppet M, Fester A, Fodun P (1999). In vitro Antisickling Activity of a Rearranged Limonoid Isolated from Khaya senegalensis. Planta Med. 65(3): 209-212.
Gill LS (1992). Ethnomedical Uses of Plants in Nigeria. University of Benin Press; Be¬nin, Nigeria.
Hamburger M, Hostettmann K (1991). Bioactivity in plants: the link between phytochemistry and medicine. Phytochemistry 30: 3864-3874.
Ibrahim MA, Musa AM, Aliyu AB, Mayaki HS, Gideon A, Islam MS (2013). Phenolics-rich fraction of Khayasenegalensisstem bark: antitrypanosomal activity and amelioration of some parasite-induced pathological changes. Pharm Biol.;51:906-13.
Igwe OU, Onwu FK (2015). Leaf Essential Oil of Sennaalata Linn from South East Nigeria and its Antimicrobial Activity. IJRPC 2015, 5(1), 27-33.
Kolawole OT, Kolawole SO, Ayankunle AA, Olaniran OI (2012). Anti-hyperglycemic effect of Khayasenegalensisstem bark aqueous extract in Wistar rats. European Journal of Medicinal Plants. 2(1):66-73.
Lompo M, Nikiema JB, Guissou IP, Moes AJ, Fontaine J (1998). “The topical anti-inflammatory effect of chloroform extracts from Khayasenegalensis stem barks,” Phytotherapy Research, 12: 448–450.
Lopes JCA, Jennings SB, MatniNM (2008). Planting mahogany in canopy gaps created by commercial harvesting. Forest Ecology and Management, 255: 300-307.
Maydell HJ (1986). Trees and Shrubs of Sahel –Their Characteristics and Uses. Gesdtschaft, Fur. Pp. 105-110.
Ndjonka D, Agyare C, Lüersen K, Djafsia B, Achukwi D, Nukenine EN Hensel A, Liebau E (2011). In vitro activity of Cameroonian and Ghanaian medicinal plants on parasitic (Onchocercaochengi) and free-living (Caenorhabditiselegans) nematodes. J Helminthol;85:304-12.
Ofori DA, Opuni-FrimpongE, Cobbinah JR (2007). Provenance variation in Khayaspecies for growth and resistanceto shoot borer Hypsipylarobusta.-Forest Ecology and Management, 242: 438-443.
Rabadeaux C, Vallette L, Sirdaarta J, Davis C, Cock IE (2017). An examination of the Antimicrobial and Anticancer Properties of Khayasenegalensis (Desr.) A. Juss. Bark Extracts. Pharmacogn J. 2017; 9(4): 504-518.
Sule MS, Abdulraheem RB, Aminu BM (2008). Potency of Aqueous stem bark extract of Khayasenegalensis against Liver diseases in Rats. Bajopas 1(1):29 – 31.
Sanni DM, Omotoyinbo OV (2016). GC-MS Analysis of PteleopsissuberosaStem BarkMethanol-Chloroform Extract. Journal of Plant Sciences; 4(3): 37-40.
Zhang H, Tan J, VanDerveer D, Wang X, Wargovich MJ, Chen F. (2009). Khayanolides from African mahogany Khayasenegalensis (Meliaceae): A revision. Phytochemistry.; 70(2):294-9.
Abdelgaleil SA, Iwagawa T, Doe M, Nakatani M (2004). Antifungal limonoids from the fruits of Khayasenegalensis. Fitoterapia.,75(6):566-572.
WHO (1998). Regulatory situation of herbal medcines. A worldwide review, Pp 1-5; Geneva, Switzerland.
Soares MG, Batista-Pereira LG, Fernandes JB, Correa AG, Da Silva MFGF, Vieira PC, Rodrigues Filho E, Ohashi OS (2003). Electrophysiological responses of female and male Hypsipyla grandella (Zeller) to Swetenia macrophyla essential oils. J. Chem. Ecology; 29: 2143-2151.
Parekh, J., Jadeja, D. and Chanda, S. (2005). Efficacy of aqueous and methanol extracts of some medicinal plants for potential antibacterial activity. Turk J Biol, 29: 203- 210.
Parekh, J., Karathia, N. and Chanda, S. (2006). Screening of some traditionally used medicinal plants for potential antibacterial activity. Indian J Pharm Sci, 68 (6): 832-834.
Bennett, R. N. and Wallsgrove, R. M. (1994). Secondary metabolites in plant defense mechanisms. Phytother Res 127: 617-633.
Adesokan AA, Yakubu MT, Owoyele BV, Akanji MA, Soladoye A, Lawal OK (2008). Effect of administration of aqueous and ethanolic extracts of Enantia chlorantha stem bark on brewer‟s yeast-induced pyresis in rats. Afr J Biochem Res, 2(7): 165-169.
Agyare C, Dwobeng AS, Agyepong N, Boakye YD, Mensah KB, Ayande PG, Adarkwa-Yiadom M (2013). Antimicrobial, antioxidant, and wound healing properties of Kigelia africana (Lam.) Beneth. and Strophanthus hispidus DC. Adv Pharmacol Sci, Article ID 692613, 10 pages.
Dahanukar SA, Kulkarni RA, Rege NN (2000). Pharmacology of medicinal plants and natural products. Indian J Pharmacol, 32(4): S81-S118.
Hugo WB, Russell AD (1998). Pharmaceutical Microbiology, 6th ed. Blackwell Scientific Publications, Oxford, London. pp. 258-297.
Prescott ML, Harley JP, Klein DA (2002). Microbiology 6th Ed. McGraw Hill Publishers, USA. pp 808-823.
Talaro KP, Talaro A (2001). Foundation in Microbiology. 4th ed. McGraw Hill Publishers, U.S.A. pp. 323-326.
Tsuchiya H, Sato M, Miyazaki T, Fujiwara S, Tanigaki S, Ohyama M, Tanaka T, Iinuma M (1996). Comparative study on the antibacterial activity of phytochemical flavanones against methicillin-resistant Staphylococcus aureus. J Ethnopharmacol, 50 (1): 27–34.
Scalbert A (1991). Antimicrobial properties of tannins. Phytochemistry, 30 (12): 3875- 3883.
Olowosulu AK, Ibrahim YKE (2006). Studies on the antimicrobial screening of aqueous extracts of five plants used in Folk medicine in Nigeria. West African J Biol Sc, 3(5): 21-26.
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