Post-Transcriptional Gene Regulation by MicroRNA and RNA-Binding Protein
Biomedical Sciences
Volume 2, Issue 3, May 2016, Pages: 16-23
Received: Jul. 4, 2016; Accepted: Jul. 22, 2016; Published: Aug. 22, 2016
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Tomoki Chiba, Department of Systems BioMedicine, Graduate school of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan
Yoshiaki Ito, Department of Systems BioMedicine, Graduate school of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan
Hiroshi Asahara, Department of Systems BioMedicine, Graduate school of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan; Department of Molecular and Experimental Medicine, the Scripps Research Institute, La Jolla, USA
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Recent advanced studies have demonstrated that post-transcriptional gene regulation is involved in many aspects of biological processes and in the pathogenesis of various types of disorders, such as neurodegenerative diseases, autoimmune diseases, and cancer. In addition to transcriptional regulation, spatially and temporally regulated gene expression is achieved by the post-transcriptional control of transcribed RNAs, including through splicing, export, stability, localization, and translation. These processes are regulated by the formation of ribonucleoprotein complexes with RNA-binding proteins and small non-coding RNAs. Here, we will describe the findings obtained from studies on mice deficient for individual RNA-binding proteins and microRNAs involved in maintaining homeostasis or causing disease.
Post-Transcriptional Regulation, MicroRNA, RNA-Binding Protein, Knockout Mice
To cite this article
Tomoki Chiba, Yoshiaki Ito, Hiroshi Asahara, Post-Transcriptional Gene Regulation by MicroRNA and RNA-Binding Protein, Biomedical Sciences. Vol. 2, No. 3, 2016, pp. 16-23. doi: 10.11648/
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