Beta-hydroxy-beta-methylbutyrate Inhibits Lipopolysaccharide-induced Interleukin-6 Expression by Increasing Protein Phosphatase-1α Expression
Volume 1, Issue 1, May 2015, Pages: 1-5
Received: May 15, 2015;
Accepted: May 25, 2015;
Published: May 26, 2015
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Mitsutaka Yakabe, Department of Geriatric Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
Sumito Ogawa, Department of Geriatric Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
Hidetaka Ota, Department of Geriatric Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
Katsuya Iijima, Department of Geriatric Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
Masato Eto, Department of Geriatric Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
Yasuyoshi Ouchi, Department of Geriatric Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan; Federation of National Public Service Personnel Mutual Aid Associations, Toranomon Hospital, Tokyo, Japan
Masahiro Akishita, Department of Geriatric Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
Beta-hydroxy-beta-methylbutyrate (HMB), a leucine metabolite, has been suggested to inhibit inflammation. However, its mechanism is not fully understood. Here we show that HMB repressed LPS-induced interleukin-6 (IL-6) expression by inhibiting the NF-B and AP-1 pathways. When protein phosphatase-1 (PP1) was knocked down, the effects of HMB were partly abrogated. We conclude that HMB might repress inflammation by modulating PP1 and its downstream NF-B and AP-1 pathways.
Beta-hydroxy-beta-methylbutyrate Inhibits Lipopolysaccharide-induced Interleukin-6 Expression by Increasing Protein Phosphatase-1α Expression, Biomedical Sciences.
Vol. 1, No. 1,
2015, pp. 1-5.
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