Band 3 Protein Function and Oxidative Stress in Erythrocytes from Systemic Sclerosis Patients with Interstitial Lung Disease
European Journal of Clinical and Biomedical Sciences
Volume 3, Issue 4, August 2017, Pages: 80-84
Received: May 16, 2017; Accepted: Jun. 28, 2017; Published: Jul. 27, 2017
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Authors
Rossana Morabito, Department Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Messina, Italy
Alessia Remigante, Department Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Messina, Italy
Gianluca Bagnato, Department Clinical and Experimental Medicine, University of Messina, Messina, Italy
William Neal Roberts, Department Medicine, University of Louisville, Kentucky, US
Davide Sciortino, Department Clinical and Experimental Medicine, University of Messina, Messina, Italy
Tommaso D’Angelo, Department Biomedical Sciences and Morphological and Functional Imaging, University of Messina, Messina, Italy
Filippo Iannelli, Department Clinical and Experimental Medicine, University of Messina, Messina, Italy
Dario Iannelli, Department Clinical and Experimental Medicine, University of Messina, Messina, Italy
Francesca Cordova, Department Clinical and Experimental Medicine, University of Messina, Messina, Italy
Mariateresa Cirillo, Department Clinical and Experimental Medicine, University of Messina, Messina, Italy
Giuseppina La Spada, Department Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Messina, Italy
Angela Marino, Department Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Messina, Italy
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Abstract
A link between reactive oxygen species (ROS) and Systemic Sclerosis (SSc) development has been already described, along with an oxidative stress-induced reduction of anion exchange capability through Band 3 protein. On this basis, blood from SSc patients has been collected to measure the rate constant for SO4= uptake, which is an index for anion exchange capability through Band 3 protein. This parameter was significantly reduced in SSc patients, with or without Interstitial Lung Disease, a complication of SSc. As a reduced Band 3 protein function was observed in SSc patients with either low or high levels of malonildialdehyde (MDA), the end product of lipoperoxidation, anion exchange through erythrocytes membrane may be not univocally related to oxidative stress and, what is more, can be considered as a sensitive tool to monitor SSc development.
Keywords
Band 3 Protein, Erythrocytes, Interstitial Lung Disease, Oxidative Stress, Systemic Sclerosis
To cite this article
Rossana Morabito, Alessia Remigante, Gianluca Bagnato, William Neal Roberts, Davide Sciortino, Tommaso D’Angelo, Filippo Iannelli, Dario Iannelli, Francesca Cordova, Mariateresa Cirillo, Giuseppina La Spada, Angela Marino, Band 3 Protein Function and Oxidative Stress in Erythrocytes from Systemic Sclerosis Patients with Interstitial Lung Disease, European Journal of Clinical and Biomedical Sciences. Vol. 3, No. 4, 2017, pp. 80-84. doi: 10.11648/j.ejcbs.20170304.12
Copyright
Copyright © 2017 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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