Band 3 Protein Function and Oxidative Stress in Erythrocytes from Systemic Sclerosis Patients with Interstitial Lung Disease
European Journal of Clinical and Biomedical Sciences
Volume 3, Issue 4, August 2017, Pages: 80-84
Received: May 16, 2017;
Accepted: Jun. 28, 2017;
Published: Jul. 27, 2017
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Rossana Morabito, Department Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Messina, Italy
Alessia Remigante, Department Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Messina, Italy
Gianluca Bagnato, Department Clinical and Experimental Medicine, University of Messina, Messina, Italy
William Neal Roberts, Department Medicine, University of Louisville, Kentucky, US
Davide Sciortino, Department Clinical and Experimental Medicine, University of Messina, Messina, Italy
Tommaso D’Angelo, Department Biomedical Sciences and Morphological and Functional Imaging, University of Messina, Messina, Italy
Filippo Iannelli, Department Clinical and Experimental Medicine, University of Messina, Messina, Italy
Dario Iannelli, Department Clinical and Experimental Medicine, University of Messina, Messina, Italy
Francesca Cordova, Department Clinical and Experimental Medicine, University of Messina, Messina, Italy
Mariateresa Cirillo, Department Clinical and Experimental Medicine, University of Messina, Messina, Italy
Giuseppina La Spada, Department Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Messina, Italy
Angela Marino, Department Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Messina, Italy
A link between reactive oxygen species (ROS) and Systemic Sclerosis (SSc) development has been already described, along with an oxidative stress-induced reduction of anion exchange capability through Band 3 protein. On this basis, blood from SSc patients has been collected to measure the rate constant for SO4= uptake, which is an index for anion exchange capability through Band 3 protein. This parameter was significantly reduced in SSc patients, with or without Interstitial Lung Disease, a complication of SSc. As a reduced Band 3 protein function was observed in SSc patients with either low or high levels of malonildialdehyde (MDA), the end product of lipoperoxidation, anion exchange through erythrocytes membrane may be not univocally related to oxidative stress and, what is more, can be considered as a sensitive tool to monitor SSc development.
William Neal Roberts,
Giuseppina La Spada,
Band 3 Protein Function and Oxidative Stress in Erythrocytes from Systemic Sclerosis Patients with Interstitial Lung Disease, European Journal of Clinical and Biomedical Sciences.
Vol. 3, No. 4,
2017, pp. 80-84.
Yang W, Fu J, Yu M, Wang D, Rong Y, Yao P, et al. Effects of three kinds of curcuminoids on anti-oxidative system and membrane deformation of human peripheral blood erythrocytes in high glucose levels. Cell Physiol Biochem.2015, 35:789–802.
Macchi B, Di Paola R, Marino-Merlo F, Felice MR, Cuzzocrea S, Mastino A. Inflammatory and cell death pathways in brain and peripheral blood in Parkinson’s disease. CNS Neurol Disord Drug Targets. 2015; 14(3):313–24.
Liochev SI. Reactive oxygen species and the free radical theory of aging. Free Radic Biol Med. 2013; 60:1–4.
Zheng YP, Xu DH. Zn(II)–curcumin protects against hemorheological alterations, oxidative stress and liver injury in a rat model of acute alcoholism. Env Toxicol Pharmacol. 2014; 37:729–37.
Morabito R, Remigante A, Cavallaro M, Taormina A, La Spada G, Marino A. Anion exchange through band 3 protein in canine leishmaniasis at different stages of disease. Pflugers Arch. 2017; 469(5-6):713-24.
Bourji K, Meyer A, Chatelus E, Pincemail J, Pigatto E, Defraigne JO.,et al. High reactive oxygen species in fibrotic and nonfibrotic skin of patients with diffuse cutaneous systemic sclerosis. Free Radic Biol Med. 2015; 87:282-9. doi: 10.1016/j.freeradbiomed.2015.07.002.
Ogawa F, Shimizu K, Muroi E, Hara T, Sato S. Increasing levels of serum antioxidant status, total antioxidant power, in systemic sclerosis. Clin Rheumatol. 2011; 30(7):921-5.
Cruz-Domínguez MP, Montes-Cortes DH, Olivares-Corichi IM, Vera-Lastra O, Medina G, Jara LJ. Oxidative stress in Mexicans with diffuse cutaneous systemic sclerosis. Rheumatol Int. 2013; 33(9):2261-7.
Tsou PS, Talia NN, Pinney AJ, Kendzicky A, Piera-Velazquez S, Jimenez SA, et al. Effect of oxidative stress on protein tyrosine phosphatase 1B in scleroderma dermal fibroblasts. Arthritis Rheum. 2012; 64(6):1978-89. doi: 10.1002/art.34336.
Fabrini R, Rosato E, Gigante A, Bocedi A, Cianci R, Barbano B, et al. Erythrocyte glutathione transferase: a non-antibody biomarker for systemic sclerosis, which correlates with severity and activity of the disease. Cell Death Dis. 2013; 4:e736. doi: 10.1038/cddis.2013.255.
Bitto A, Bagnato GL, Pizzino G, Roberts WN, Irrera N, Minutoli L, et al. Simvastatin prevents vascular complications in the chronic reactive oxygen species murine model of systemic sclerosis. Free Radic Res. 2016; 50(5):514-22. doi: 10.3109/10715762.2016.1149171.
Romano L, Passow H. Characterization of anion transport system in trout red blood cell. Am J Physiol. 1984; 246(3 Pt 1):C330-8.
Reithmeier RAF, Casey JR, Kall AC, Sansomc MSP, Alguel Y, Iwata S. Band 3, the human red cell chloride/bicarbonate anion exchanger (AE1, SLC4A1), in a structural context. Biochim Biophys Acta. 2016; 1858:1507–32.
Chernyshova ES, Zaikina YS, Tsvetovskaya GA, Strokotov DI, Yurkin MA, Serebrennikova ES, et al. Influence of magnesium sulfate on HCO3/Cl transmembrane exchange rate in human erythrocytes. J Theor Biol. 2016; 393:194-202.
Morabito R, Remigante A, Di Pietro ML, Giannetto A, La Spada G, Marino A. SO4= uptake and catalase role in preconditioning after H2O2-induced oxidative stress in human erythrocytes. Pflugers Arch. 2017; 469(2):235-250. doi: 10.1007/s00424-016-1927-1.
Pantaleo A, Ferru E, Pau MC, Khadjavi A, Mandili G, Mattè A, et al. Band 3 erythrocyte membrane protein acts as redox stress sensor leading to its phosphorylation by p (72) Syk. Oxidative Med Cell Longev. 2016:6051093.
Salhany JM, Sloan RL, Cordes KA. In situ cross-linking of human erythrocyte Band 3 by bis (sulfosuccinimidyl) suberate. Evidence for ligand modulation of two alternate quaternary forms: covalent band 3 dimers and noncovalent tetramers formed by the association of two covalent dimers. J Biol Chem. 1990; 265:17688–93.
Franke RF, Scharnweber T, Fuhrmann R, Wenzel F, Kruger A, Mrowietz C, Jung F.Effect of radiographic contrast media on the spectrin/band 3-network of the membrane skeleton of erythrocytes. Plos One. 2014; 9(2):e89512.
Morabito R, Romano O, La Spada G, Marino A. H2O2-induced oxidative stress affects SO4= transport in human erythrocytes. PLoS One. 2016; 11(1):e0146485. doi: 10.1371/journal.pone.0146485.
Morabito R, Marino A, Romano P, Rigano C, La Spada G. Sulphate and chloride-dependent potassium transport in human erythrocytes are affected by crude venom from nematocysts of the jellyfish Pelagia noctiluca. Cell Physiol Biochem. 2013; 32:86–95.
Solans R, Motta C, Solá R, La Ville AE, Lima J, Simeón P, et al. Abnormalities of erythrocyte membrane fluidity, lipid composition, and lipid peroxidation in systemic sclerosis: evidence of free radical-mediated injury. Arthritis Rheum. 2000; 43(4):894-900.
Giovannetti A, Gambardella L, Pietraforte D, Rosato E, Giammarioli AM, Salsano F, et al. Red blood cell alterations in systemic sclerosis: a pilot study. Cell Physiol Biochem. 2012; 30(2):418-27.