Genetic Basis of Idiosyncratic Responses to Alcoholism
European Journal of Clinical and Biomedical Sciences
Volume 2, Issue 6, December 2016, Pages: 63-68
Received: Oct. 7, 2016; Accepted: Nov. 11, 2016; Published: Dec. 12, 2016
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Charles Ejike Osuji, Biotechnology Advanced Research Center, Sheda Science and Technology Complex (SHESTCO), Abuja, Nigeria
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Abstract
Aim: The scientific viewpoint of genetic polymorphisms associated with risk of alcoholism and its adverse individual behavioural reactions is the main focus of this review. A complex syndrome like alcoholism and its idiosyncrasy may not be entirely understood on the basis of pathophysiological concept of neurotransmission alone. While neuropharmacology explains the mechanism behind molecular basis of alcoholism, the variation in alcohol induced abnormal neurotransmission due to presence or absence of different gene variants or isoenzymes of a particular gene on the other hand is a strong indication of genetic predisposition to alcoholism. In this article the term alcohol is used as a generic name for ethanol, which is the main subject of this discussion. Conclusion: The concomitant untoward intrinsic toxicity associated with alcoholism that makes it a potential trigger to a myriad of abnormal behavioural reactions in not only dose dependent pattern but with strong genetic disposition arises majorly due to different modes and levels of genetic variation in metabolic enzymes.
Keywords
Alcoholism, Genetic, Polymorphism Neurotransmission, Enzymes, ALDH, ADH, Cytochrome P450
To cite this article
Charles Ejike Osuji, Genetic Basis of Idiosyncratic Responses to Alcoholism, European Journal of Clinical and Biomedical Sciences. Vol. 2, No. 6, 2016, pp. 63-68. doi: 10.11648/j.ejcbs.20160206.12
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This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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