The 1918 Spanish Flu Pandemic, the Origins of the H1N1-virus Strain, a Glance in History
European Journal of Clinical and Biomedical Sciences
Volume 2, Issue 4, August 2016, Pages: 23-28
Received: Sep. 14, 2016;
Accepted: Oct. 12, 2016;
Published: Oct. 28, 2016
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Gregory Tsoucalas, History of Medicine, Faculty of Medicine, University of Thessaly, Larissa, Greece
Antonios Kousoulis, London School of Hygiene & Tropical Medicine, Faculty of Epidemiology and Population Health, London, UK
Markos Sgantzos, History of Medicine, Faculty of Medicine, University of Thessaly, Larissa, Greece; Department of Anatomy, Faculty of Medicine, University of Thessaly, Larissa, Greece
It was the year 1918, when a new flu pandemic launched worldwide. Our study purports to depict the general icon of the 1918 pandemic epoch, for the readers to shape an overview of the events of the era. We have used some of the most important manuscripts concerning the pandemic to compose a historical note on the outbreak that almost annihilated the world. The name “Spanish Flu”, was defined wrongfully due to the scientific observation and research made in Spain, while the first appearance of the virus had been made in USA. The outbreak was devastating, causing millions to die, more than the First World War casualties. During new experiments upon the old virus strain, it was proved that the 1918 pandemic was caused by an influenza A - subtype H1N1 progenitor strain. Our mini review, enlightens some aspects of virus blast, in an effort for the readers to luxuriate in the tale, myths, and the true story of the 1918 pandemic.
The 1918 Spanish Flu Pandemic, the Origins of the H1N1-virus Strain, a Glance in History, European Journal of Clinical and Biomedical Sciences.
Vol. 2, No. 4,
2016, pp. 23-28.
Pike B, Saylors K, Fair J, et al. The Origin and Prevention of Pandemics. Clinical Infectious Diseases, 2010; 50: 1636-1640.
Frith J. The History of Plague-Part 1. The Three Great Pandemics. JMVH 2012; 20(2): 11-16.
Aberth J. Plagues in world history. Rowman & Littlefield Publishers INC, Lanham, 2011.
Duncan K. Hunting the 1918 flu: one scientist's search for a killer virus. University of Toronto Press, Toronto, 2003.
Theodorides J. Des miasmes aux virus. Editions Louis Pariente, Paris, 1991.
Patterson KD, Pyle GF. The geography and mortality of the 1918 influenza pandemic. Bull Hist Med 1991; 65(1): 4-21.
Connor S. Flu epidemic traced to Great War transit camp. The Guardian (UK), Saturday, 8 January 2000.
Barry JM. The Great Influenza: The Epic Story of the Greatest Plague in History. Viking Penguin, New York, 2004.
Jordan E. Epidemic influenza: a survey. American Medical Association, Chicago, 1927.
Shope RE. Swine Influenza III, filtration, experiments and etiology. J Exp Med. 1931; 54(3): 373-385.
Greenwood M. The epidemiology of influenza. BMJ 1918; 2(3021): 563-566.
Tsoucalas G, Karachaliou F, Kalogirou V, Gatos G, Mavrogiannaki E, Antoniou A, Gatos K. The first announcement about the 1918 “Spanish flu” pandemic in Greece through the writings of the pioneer newspaper “Thessalia” almost a century ago. Infez Med. 2015; 23(1): 79-82.
Duncan K. Hunting the 1918 Flu: One Scientist's Search for a Killer Virus. University of Toronto Press, Toronto, 2003.
Collier R. The Plague of the Spanish Lady: The Influenza Pandemic of 1918-1919. Allison & Busby, London, 1996.
Ewald PW. Evolution of Infectious Disease, Oxford University Press, New York, 1994.
Robertson WF. Influenza: Its cause and prevention. Br Med J. 1918; 2(3025): 680-681.
Taubenberger J, Morens D. 1918 Influenza: the mother of all pandemics. Emerg Infect Dis 2006; 12 (1): 16-22.
Taubenberger JK, Kash JC. Insight on influenza pathogenesis from the grave. Virus Res 2011; 162(1-2): 2-7.
Wilton P. Spanish flu outdid WWI in number of lives claimed. CMAJ. 1993; 148(11): 2036-2037.
Pandemics and Pandemic Threats since 1900. U.S. Department of Health & Human Services. http://www.flu.gov/pandemic/history, Accessed 8/12/2013.
Simonsen L, Clarke M, Schonberger L, Arden N, Cox N, Fukuda K. Pandemic versus epidemic influenza mortality: a pattern of changing age distribution. J Infect Dis 1998; 178 (1): 53-60.
G. Tsoukalas, M. Karamanou, G. Androutsos. Travelling through time with Aspirin, a healing companion. MS EJI 2011; 9: 13-17.
Collier's Encyclopedia. 1974 Collier's Yearbook Covering the Year 1973. Macmillan, New York 1974.
Reid AH, Janczewski TA, Lourens RM, Elliot AJ, Daniels RS, Berry CL, et al. 1918 influenza pandemic caused by highly conserved viruses with two receptor-binding variants. Emerg Infect Dis. 2003; 9: 1249-1253.
Reid A, Fanning T, Taubenberger. Origin and evolution of the 1918 “Spanish” influenza virus hemagglutinin gene. Proc Natl Acad Sci USA 1999; 96(4): 1651-1656.
Lucke B. Pathologic Anatomy and Bacteriology of Epidemic of Autumn, 1918. Arch Intern Med (Chic) 1919; 24(2): 154-237.
Hirst GK. The agglutination of red blood cells by allantoic fluid of chick embryos infected with influenza virus. Science 1941; 94: 22-23.
Crosby AW. America's Forgotten Pandemic: The Influenza of 1918. Cambridge University Press, Cambridge, 2003.