American Journal of Heterocyclic Chemistry
Volume 4, Issue 4, December 2018, Pages: 49-54
Received: Nov. 19, 2018;
Accepted: Dec. 8, 2018;
Published: Jan. 25, 2019
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Timothy Omara, Department of Health Sciences, Unicaf University, Lusaka, Zambia; Department of Quality Control, Quality Assurance and Product Development, AgroWays Uganda Limited, Jinja, Uganda; Department of Chemistry, Faculty of Science, Kyambogo University, Kampala, Uganda; Department of Quality Control and Quality Assurance, Leading Distillers Uganda Limited, Kampala, Uganda
Bashir Musau, Department of Chemistry, Faculty of Science, Kyambogo University, Kampala, Uganda; Department of Quality Control and Quality Assurance, Leading Distillers Uganda Limited, Kampala, Uganda
Sarah Kagoya, Department of Chemistry, Faculty of Science, Kyambogo University, Kampala, Uganda
Agrotransformation of tobacco leaves into cigarettes and cigars spawns upto 75% wastes which is an environmental and public nuisance owing to its noxious 0.6-3% (w/w) 3-(1-methyl-2-pyrrolindyl) pyridine (MPP) content. Considerately, this volumetric agrowaste is a prodigal loss during tobacco processing. Consequently, the utilization of these frugal wastes as a substrate for pyridine-3-carboxylic acid (PCA) synthesis is a green strategy to obliterate the ecological backlashes of tobacco waste. This concerted study reported the feasibility of utilizing Flue-Cured Virginia (FCV) tobacco waste as a starting substrate for synthesis of pyridine-3-carboxylic acid through MPP as a synthetic intermediate. The intermediate was extracted from powdered FCV wastes using petroleum ether and subsequently oxidized to PCA using 69% concentrated Nitric acid of volumes: 120, 115, 110,105, 100, 95, 90 and 85ml at 87±2°C. The results of the bench scale experiments indicated that the yield of PCA increases with increase in the volume of hot nitric acid; a maximum yield of 25ml was obtained with 100ml of hot nitric acid. The lowest yield of 17ml was from 85ml of hot nitric acid. MPP had a statistical mean boiling point of 249.3±2.082°C, mean density of 1.024±0.006g/cm3 whereas PCA had a mean boiling point of 262±3°C, mean density of 1.505843±0.05503g/cm3, mean pH of 3.3±0.19 and a computed mean solubility of 1.5±0.017g/L. The study has shown that FCV tobacco leaf wastes is a green environmental substrate for organic synthesis of pyridine-3-carboxylic acid.
Frugal Utilization of Flue-Cured Virginia Nicotiana tabacum Leaf Wastes as a Vicissitudinous Substrate for Optimized Synthesis of Pyridine-3-Carboxylic Acid, American Journal of Heterocyclic Chemistry.
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