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Antimicrobial Activity of Mn Complexes Incorporating Schiff Bases: A Short Review
American Journal of Heterocyclic Chemistry
Volume 5, Issue 2, June 2019, Pages: 27-36
Received: May 8, 2019; Accepted: Jun. 12, 2019; Published: Jul. 1, 2019
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Sharif Uddin, Department of Chemistry, Rajshahi University, Rajshahi, Bangladesh
Md. Saddam Hossain, Department of Chemistry, Begum Rokeya University, Rangpur, Bangladesh
Md. Abdul Latif, Department of Chemistry, Begum Rokeya University, Rangpur, Bangladesh
Md. Rabiul karim, Department of Chemistry, Rajshahi University, Rajshahi, Bangladesh
Ranjan K. Mohapatra, Department of Chemistry, Government College of Engineering, Keonjhar, Odisha, India
Md. Kudrat-E-Zahan, Department of Chemistry, Rajshahi University, Rajshahi, Bangladesh
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Antibiotic resistance has been growing at an anxious rate and as a result the activity of antibiotics against Gram-negative and Gram-positive bacteria has dropped dramatically day by day. Metal ions play many critical functions in humans. Deficiency of some metal ions can lead to disease like pernicious anemia, growth retardation, heart disease in infants etc. In this sense there is a strong need to synthesis new substances that not only have good spectrum of activity, but having new mechanisms of action. Inorganic compounds particularly Mn metal complexes have played an important role in the development of new metal based drugs. Over the past few years, there have been many reports on their applications in homogeneous and heterogeneous catalysis. The activity is usually increased by complexation therefore to understand the properties of both ligands and metal can lead to the synthesis of highly active compounds. The influence of certain metals on the biological activity of these compounds and their intrinsic chemical interest as multidentate ligands has prompted a considerable increase in the study of their coordination behavior. Development of a new chemotherapeutic Schiff bases and their metal complexes is now attracting the attention of medicinal chemists. In this review we have focused on research of Mn complexes incorporation of Schiff bases carry out over the past few decades which has sought to possess preclinical pharmacological screenings like anti-bacterial, anti-fungal, anti-tuberculosis, anti-inflammatory, anti-cancer, DNA- interaction and anti-tumor action of synthetic metal complexes.
Schiff Bases, Mn Complexes, Metal Based Drugs, Antibacterial, Anti-Inflammatory
To cite this article
Sharif Uddin, Md. Saddam Hossain, Md. Abdul Latif, Md. Rabiul karim, Ranjan K. Mohapatra, Md. Kudrat-E-Zahan, Antimicrobial Activity of Mn Complexes Incorporating Schiff Bases: A Short Review, American Journal of Heterocyclic Chemistry. Vol. 5, No. 2, 2019, pp. 27-36. doi: 10.11648/j.ajhc.20190502.12
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Chohan, Z. H.; Sheazi, S. K. A. Synthesis and characterization of some Co (II), Cu (II) and Ni (II) complexes with nicolinylhydrazine derivatives and their biological role of metals and anions on the antibacterial properties. Synth. React. Inorg. Met.-Org. Chem. 1999, 29, 105-118.
Jayabalakrishnan, C.; Natarajan. K. Synthesis, characterization and biological activities of ruthenium (II) carhonyl complexes containing bifunctional tridentate Schiff bases. Synth. React. Inorg. Met.-Org. Chem. 2001, 31, 983-995.
Jeeworth, T.; Wah, H. L. K.; Bhowon, M. G.; Ghoorhoo. D.; Babooram, K. Synthesis and antibacterial/catalytic properties of schiff bases and Schiff base metal complexes derived from2, 3-diaminopyridine. Synth. React. Inorg. Met.-Org. Chem. 2000, 30, 1023-1038.
Dharmaraj, N.; Viswanalhamurthi, P.; Natarajan. K. Ruthenium (Il) complexes containingbidentate Schiff bases and their antifungal activity. Transit. Metal Chem. 2001, 26, 105-109.
Colins, C. H.; Lyne, P. M. In Microbiul Methods; University Park Press: Baltimore, 1970.
Savanini, L; Chiasserini, L; Gaeta, A.; C. Pellerano. Synthesis and anti-tubercular evaluation of 4-quinolylhydrazones. Biorg. Med. Chem. 2002, 10, 2193-2198.
Ochiai, Ei-ichiro. Bioinorganic Chemistry; Allyn and Bacon: Boston, 1977.
Ferrari, M. B.; Capacchi, S.; Pelosi, G.; Reffo, G.; Tarasconi, P.; Alberlini, R.; Pinelli, S.; Lunghi, P. Synthesis, structural characterization and biological activity of helicon thiosemicarbazone monohydrate and a copper (II) complex of salicyaldehyde thiosemicarbazone. Inorg. Chim. Acta 1999, 286, 134-141.
Agarwal, R. K.; Singh, L.; Sharma, D. K.; Singh, R. Synthesis, spectral and thermal investigationsof some oxovanadium (IV) complexes of isonicotinic acid hydrazide. Turk J. Chem. 2005, 29, 309-310.
Elo, H.; Sunila, I.; Lumme, P. Studies on the acute toxicity of antineoplastic metal chelate. Transbis (salicyaldoximato) copper(II) in rats. Inorg. Chim. Acta1987, 136, 61-63.
Elo, H.; Lumme, P. Trans-bis (salicyaldoximato) copper (II) and its derivatives as antipyroliterative and antineoplastic agents. Inorg. Chim. Acta1987, 136, 149-153.
Ali, M. A,:Kabir, M. H.; Nazimuddin. M.; Majumder, S. M. H.; Tarafder, M. T. H.; Akhair, M. Synthesis, characterization and antifungal properties of some four-coordinate nickel (II) and four and five-coordinate copper (II) complexes containing tridentate thiosemicarbazones and heterocyclic bases. Indian J. Chem. 1988, 27A, 1064-1067.
Mohammad S, Summaiya H, Mohammed S, Owais M, Mohammad A, Saud, IA (2016). Pharmacophore hybrid Approach of New Modulated bis-diimine CuII/ZnII Complexes based on 5-chloro Isatin Schiff base Derivatives Synthesis, Spectral Studies and Comparative Biological Assessment. Journal of Photochemistry & Photobiology. 157, 39–56.
S. D. Angadi, R. K. Shikkargoi, N. N. Millikarjuna, K. Siddapa and V. H. Kulkarni, E. Journal Chem. 2003, 5, 566.
H. S. Seleem, Stability Constants and Thermodynamic Parameters of Mn2+Co2+, Ni2+ Complexes with Some Schiff Base Hydrazones Containing the Pyrimidine Moiety, Ann. Chem., (2003) pp. 305-314.
Sathe BS, Jaychandran E, Jagtap VA, Sreenivasa GM. Synthesis characterization and anti-inflammatoryevaluation of new fluorobenzothiazoleschiff’s bases. International Journal of Pharmaceutical Research and Development. 2011; 3 (3):164-169.
Sondhi SM, Singh N, Kumar A, Lozach O, Meijer L. Synthesis, anti-inflammatory, analgesic and kinase (CDK-1, CDK-5 and GSK-3) inhibition activityevaluation of benzimidazole/benzoxazole derivatives andsome Schiff ’s bases, Bioorganic and Medicinal Chemistry. 2006; 14 (11):3758-3765.
Pandey A, Dewangan D, Verma S, Mishra A, DubeyRD. Synthesis of schiff bases of 2-amino-5-aryl-1, 3, 4-thiadiazole and its analgesic, anti-inflammatory, antibacterial and antitubercular activity. International Journal of ChemTech Research. 2011; 3 (1):178-184.
Chandramouli C, Shivanand MR, NayanbhaiTB, Bheemachari B, Udupi RH. Synthesis and biological screening of certain new triazole schiff bases and their derivatives bearing substituted benzothiazole moiety, Journal of Chemical and Pharmaceutical Research. 2012; 4 (2):1151-1159.
Chinnasamy RP, Sundararajan R, GovindarajS. Synthesis, characterization, and analgesic activity of novel schiff base of isatin derivatives. Journal of Advanced Pharmaceutical Technology and Research. 2010; 1 (3):342-347.
Mounika K, Anupama B, Pragathi J, Gyanakumari C. Synthesis, characterization and biological activity of a Schiff base derived from 3-ethoxy salicylaldehyde and 2-amino benzoic acid and its transition metal complexes. Journal of Scientific Research. 2010; 2 (3):513-524.
Venkatesh P. Synthesis, characterization and antimicrobial activity of various Schiff bases complexes of Zn (II) and Cu (II) ions. Asian Journal of Pharmaceutical and Health Sciences. 2011; 1 (1):8-11.
Chaubey AK, Pandeya SN. Synthesis & anticonvulsant activity (Chemo Shock) of Schiff and Mannich bases of Isatin derivatives with 2-Amino pyridine (mechanism of action), International Journal of Pharm Tech Research. 2012; 4 (4):590-598.
Aboul-Fadl T, Mohammed FA, Hassan EA. Synthesis, antitubercular activity and pharmacokinetic studies of some Schiff bases derived from 1- alkylisatin andisonicotinic acid hydrazide (INH),” Archives of Pharmacal Research. 2003; 26(1):778-784.
Miri R, Razzaghi-asl N, Mohammadi MK. QM study and conformational analysis of an isatin Schiff base as a potential cytotoxic agent. Journal of Molecular Modeling. 2013; 19 (2):727-735.
Ali SMM, Abul Kalam Azad M, Jesmin M. In vivo anticancer activity of Vanillin semicarbazone, AsianPacific Journal of Tropical Biomedicine. 2012; 2 (6):438-442.
Wei D, Li N, Lu G, Yao K. Synthesis, catalytic and biological activity of novel dinuclear copper complexwith Schiff base. Science in China B. 2006; 49 (3):225-229.
Avaji PG, Vinod Kumar CH, Patil SA, Shivananda KN, Nagaraju C. Synthesis, spectral characterization, in-vitro microbiological evaluation and cytotoxic activities of novel macrocyclic bis hydrazone. European Journal of Medicinal Chemistry. 2009; 49 (9):3552-3559.
Venugopala KN, Jayashree BS. Synthesis of carboxamides of 2-amino-4-(6-bromo-3-coumarinyl)thiazole as analgesic and antiinflammatory agents, IndianJournal of Heterocyclic Chemistry. 2003; 12 (4):307-310.
Emayavaramban M, Kumar K, Mani P, Prabhakaran B, Muthuvel A. Synthesis, complexation, spectral and antimicrobial study of some novel 5 bromofluorobenzaldehydeoxime and semicarbazoneunder ultrasonic irradiation. International Journal of Advanced Chemistry. 2014; 2 (1):20-23.
Salman A Khan, Abdullah M Asiri, Khalid Al-Amry, Maqsood Ahmad Malik. Synthesis, Characterization, Electrochemical Studies, and In vitro Antibacterial.
Activity of Novel Thiosemicarbazone and Its Cu (II), Ni (II), and Co (II) Complexes. Hindawi Publishing Corporation Scientific World Journal, 2014, Article ID592375:9.
Hina Z, Anis A, Asad UK, and TahirAK. Synthesis, Characterization and Antimicrobial Studies of Schiff base Complexes. Journal of Molecular Structure, 2015, 1097, 129–135.
Sayed M. Abdallah, Gehad G. Mohamed, M. A. Zayed, Mohsen S. Abou El-Ela. Spectroscopic study of molecular structures of novel Schiff base derived fromo-phthaldehyde and 2-aminophenol and its coordination compounds together with their biological activity. SpectrochimicaActa Part A, 2009, 73, 833–840.
Md. Saddam Hossain, C. M. Zakaria, Md. Kudrat-E-Zahan. Metal Complexes as Potential Antimicrobial Agent: A Review. American Journal of Heterocyclic Chemistry. 2018, 4 (1), 1-21.
Rehab K Al-Shemary, Wurood A Jaafar, and Ali N Niseaf. Structure, Diagnosis, and in the Vitro Antimicrobial evaluation of 2-amino pyridine-derived Ligand Schiff base and its complexes with Cu (II), Hg (II), Ni (II), Mn (II) and Co (II). RJPBCS, 2017, 8 (3), 174-184.
Rabia Arshad, Iftikhar Hussain Bukhari, Fareeha Anum, Zartasha Aftab, Zahida Noreen. Synthesis, Spectral and Biological studies of transition metal complexes of schiff base derived from Ofloxacin. International Journal of Advanced Research in Biological Sciences, 2016. 3 (4), 99-108.
Sangita Sharma, Jayesh Ramani, Jasmin Bhalodia, Neha Patel, Khushbu Thakkar and Rajesh Patel. Synthesis, Characterization and Antimicrobial Activity of Some Transition Metal Complexes (Mn, Co, Zn, Ni) With L-Proline and Kojic Acid. Advances in Applied Science Research, 2011, 2 (4), 374-382.
Sandeep A. Kumbalpuri, Archana A Kachare, Sunil G ShankarwarandTrimbak K Chondhekar. Synthesis, characterization and antimicrobial activities of schiff base ligandand its metal complexes. Der Pharma Chemica, 2015, 7 (8), 88-93.
Mohanambal D. and Arul Antony S. Synthesis, Characterization and Antimicrobial activity of some novel Schiff Base 3d Transition Metal Complexes Derived from Dihydropyrimidinoneand 4- Aminoantipyrine. Research Journal of Chemical Sciences, 2014, 4 (7), 11-17.
Aishatu Salihu Mohammed, Fatima Abubakar, Abigail Ebi Aye. Synthesis, Characterization and Antifungal Activity of Manganese (II) Complex with Schiff Base Derived from Acetylacetone and Leucine. American Journal of Nano Research and Applications, 2017, 5 (6), 110-113.
Naomi P. Ndahi, HusseiniGarba, Ibrahim Waziri1, Aliu A. Osunlaja1, and Habila A. N. Putaya. Complexes of Mn (II) and Fe (III) with Schiff bases Derived from Trimethoprim with Salicyldehyde and Benzaldehydeas Potential Antimicrobial Agents. Nigerian Journal of Pharmaceutical and Biomedical Research, 2018; 3 (1):53.
Mohammad Muzammil Y. Kuddushi., Mohammed Abrar H. Malek., Vinod L. PatidarMihir S. Patel., Roma K. Patel and Rohit H. Dave. Synthesis And Characterization Of Schiff Base Aniline With 5-Bromo -2-Hydroxyl Benzaldehyde And Their Metal Complexes. International Journal Of Recent Scientific Research, 2018, 9 (4), 26026-26030.
Q. R. Liu, L. W. Xue, and G. Q. Zhao. Manganese (III) Complexes Derived from bis_Schiff Bases: Synthesis, Structures, and Antimicrobial Activity. Russian Journal of Coordination Chemistry, 2014, 40, (10), 757–763.
Selma Bal and Sedat Salih Bal. Cobalt (II) and Manganese (II) Complexes of Novel Schiff Bases, Synthesis, Charcterization, and Thermal, Antimicrobial, Electronic, and Catalytic Features. Advances in Chemistry, 2014, 1-14.
Gajendra Kumar, Dharmendra Kumar2, C. P. Singh2, Amit Kumar And V. B. Rana. Synthesis, Physical Characterization And Antimicrobial Activity Of Trivalent Metal Schiff Base Complexes. J. Serb. Chem. Soc. 2010, 75 (5), 629–637.
N Raman, JDhaveethu Raja And A Sakthivel. Synthesis, Spectral Characterization Of Schiff Base Transition Metal complexes: DNA cleavage and antimicrobial activity studies. J. Chem. Sci., 2007, 119 (4), 303–310.
I. M. Wakil, N. P. Ndahi2, M. B. Abubakar3, I. Waziri. Synthesis, Characterization, and Antimicrobial Studies of Propionaldehyde Schiff base Metal (II) Complexes. Chemistry Research Journal, 2017, 2 (2), 39-45.
E. Ispir, S. Toroglu, A. Kayraldlz. Syntheses, characterization, antimicrobial and genotoxic activities of new Schiff bases and their complexes. Transition Met Chem, 2008, 33, 953–960.
M. S. Hossain, C. M. Zakaria, M. K. Zahan. Synthesis and Characterization with Antimicrobial Activity Studies on some Transition Metal Complexes of N, O Donor Novel Schiff Base Ligand. J. Sci. Res. 2017, 9 (2), 209-218.
A. H Manikshete, M. M. Awatade, S. K. Sarsamkar, M. R. Asabe. Synthesis, characterization, antimicrobial, anticancer and antidiabetic activity of new Manganese (II), Nickel (II) and Cobalt (II) complexes with Salicylaldehyde-4-chlorobenzoylhydrazone. International Journal of Engineering Science Invention, 2015, 4 (1), 22-29.
51. S. Kondaiah, G. Naga Raja Reddy, D. Rajesh, Jacob Joseph. Synthesis, Characterization, and Antibacterial Activity of the Schiff Base Derived from P-ToluicHydrazide and o-Vanilin (OVPTH Ligand) and its Mn (II), Co (II), Ni (II) and Cu (II) Complexes. Indian Journal of Advances in Chemical Science, 2013, 1 (4), 228-235.
Sabrina Belaid, Anne Landreau, Safia Djebbar, Ouassini Benali-Baitich, Gilles Bouet, Jean-Philippe Bouchara. Synthesis, characterization and antifungal activity of a series of manganese (II) and copper (II) complexes with ligands derived from reduced N, N-O-phenylenebis (salicylideneimine), Journal of Inorganic Biochemistry, 2008, 102, 63–69.
P. Mittal And V. Uma. Coordination Behavior And Biological Activity Of Unsymmetrical Bis–Hydrazone Towards Manganese (Ii) Ion. Int. J. Chem, 2008 Sci. 2008, 6 (2), 1050-1060.
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