Anti-pathogenic Activity of Cu(II) Complexes Incorporating Schiff Bases: A Short Review
American Journal of Heterocyclic Chemistry
Volume 5, Issue 1, March 2019, Pages: 11-22
Received: Feb. 20, 2019; Accepted: Mar. 25, 2019; Published: Apr. 22, 2019
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Md. Nur Amin Bitu, Department of Chemistry, Rajshahi University, Rajshahi, Bangladesh
Md. Saddam Hossain, Department of Chemistry, Begum Rokeya University, Rangpur, Bangladesh
A. A. S. M. Zahid, Department of Chemistry, Rajshahi University, Rajshahi, Bangladesh
C. M. Zakaria, Department of Chemistry, Rajshahi University, Rajshahi, Bangladesh
Md. Kudrat-E-Zahan, Department of Chemistry, Rajshahi University, Rajshahi, Bangladesh
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Metals contribute important roles in biological system. It is recognized that metals are highly linked in cellular and subcellular functions. With the application of novel and experienced tools to study biological and biochemical systems the true role of inorganic salts in biological systems can be studied. Schiff base metal complexes show a broad range of biological activity. The activity of Schiff base ligand is usually increased by complexation with the metal ion. The copper complexes of Schiff bases have striking properties such as antibacterial, antifungal, antiviral, anti-inflammatory, anti-tumor and cytotoxic activities, plant development controller, enzymatic activity and applications in pharmaceutical fields. The divalent cations Zn2+, Ca2+ and Mg2+ prevent cytotoxicity and in vivo antagonize Cd- induced carcinogenesis. Lack of body iron is common in cancer patients and it is associated with complications in surgery and in animal experiments. The transport of iron and other metal ions by the blood plasma is achieved through the formation of protein complexes. Copper is placed as a vital metalloelement and is primarily connected with copper-dependent cellular enzymes. Metals are also used as inorganic drugs for many diseases. In this review our main focused on research undertaken for biological activity study of Cu(II) metal complexes containing Schiff bases over the past few decades.
Schiff Bases, Biological Activity, Copper Complexes, Antibacterial, Antifungal, Antiviral, Anti-inflammatory, Anti-tumor and Cytotoxic Activity
To cite this article
Md. Nur Amin Bitu, Md. Saddam Hossain, A. A. S. M. Zahid, C. M. Zakaria, Md. Kudrat-E-Zahan, Anti-pathogenic Activity of Cu(II) Complexes Incorporating Schiff Bases: A Short Review, American Journal of Heterocyclic Chemistry. Vol. 5, No. 1, 2019, pp. 11-22. doi: 10.11648/j.ajhc.20190501.14
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B. Lakshmi, K. N. Shivananda, G. A. Prakash, K. R. K. Rama and K. N. Mahendra, “Synthesis of Co(II), Ni(II) and Cu(II) Complexes from Schiff base Ligand and Reactivity Studies with Thermosetting Epoxy Resin”, Bull. Korean Chem. Soc., 2011, 32 (5): 1613 1619.
A. Alim, M. Kudrat-E-Zahan, M. M. Haque, M. T. H. Tarafder, “Synthesis and Characterization of Some Metal Complexes of Cu(II), Ni(II), Zn(II), Cd(II), Sn(II), Co(II), Sb(III) and Fe(III) Containing Bidentate Schiff Base of Smdtc”, Science Journal of Chemistry., 2014; 3 (3): 35-39.
L. Cheng, J. Tang, H. Luo, X. Jin, F. Dai, J. Yang, Y. Qian, X. Li, and B. Zhou, “Antioxidant and antiproliferative activities of hydroxyl-substituted Schiff bases”, Bioorg. Med. Chem. Lett., 2010; 20: 2417-2420.
M. S. Hossain, S. Sarker, A. S. M. Elias Shaheed, M. M. Hossain, A. Alim-Al-Bari, M. R. Karim, C. M. Zakaria, M. Kudrat-E-Zahan, “Thermal and Spectral Characterization of Cr(III), Co(II) and Cd(II) Metal Complexes Containing Bis-Imine Novel Schiff Base Ligand Towards Potential Biological Application”, Chemical and Biomolecular Engineering, 2017; 2 (1): 41-50.
G. T. Rahman, M. Kudrat-E-Zahan, M. M. Haque, M. M. Alam, M. A. Farooque, “Structural Analysis of Newly Synthesized NO Donor Schiff Base Complexes of Cu(II), Ni(II), Co(II) and Fe(III) Metal Ions by Conventional Method”, Science Journal of Chemistry, 2015; 3 (6): 91-94.
S. V. Rathod, S. S. Giri and S. D. Maind, “Synthesis, Spectral Characterization and Antimicrobial Studies of Copper(II) Complex Containing Mixed Ligands Nitrogen-Oxygen Donor Schiff Base (4-Bromo-(2-carboxyphenyl)-pyridine-2-yl ethylene amine) and 2,2’ bipyridine”, world journal of pharmaceutical research, 2016; 5 (3): 702-707.
R. Katwal, H. Kaur and B. K. Kapur, “Applications of Copper-Schiff’s Base Complexes: A Review”, Sci. Revs. Chem. Commun., 2013; 3 (1): 1-15.
M. S. Hossain, C. M. Zakaria, M. Kudrat-E-Zahan, “Metal Complexes as Potential Antimicrobial Agent: A Review”, American Journal of Heterocyclic Chemistry, 2018; 4 (1): 1-21.
N. Raman, S. Sobha, L. Mitu, “Synthesis, structure elucidation, DNA interaction, biological evaluation, and molecular docking of an isatin-derived tyramine bidentate Schiff base and its metal complexes”, Monatsh Chem., 2012; 143: 1019–1030.
M. M. Hossain, M. A. Bashar, M. N. Khan, P. K. Roy, M. A. Mannan, M. S. Ali, M. A. Farooque, “Physical and Spectral Characterization of Ni(II), Cu(II), Co(II) and Cd(II) Complexes with Schiff Base of Salicylaldehyde and 2- Aminopyridine Towards Potential Microbial Application”, American Journal of Applied Chemistry, 2018; 6 (4): 147-155.
J. A. Shampa, M. R. Islam, M. S. Hossain, G. T. Rahman, C. M. Zakaria, M. Kudrat-E-Zahan, “Physiochemical & Antibacterial Activity Investigation on Noble Schiff Base Cu(II) Complex”, American Journal of Heterocyclic Chemistry, 2017; 3 (4): 37-41.
Z. H. Chohan, M. F. Jaffery and C. T. Supuran, “Antibacterial Co(II), Cu(II), Ni(II) and Zn(II) Complexes of Thiadiazoles Schiff Bases”, Metal Based Drugs, 2001; 8 (2): 95-101.
N. K. Chaudhary and P. Mishra, “Spectral Investigation and In Vitro Antibacterial Evaluation of Ni(II) and Cu(II) Complexes of Schiff Base Derived from Amoxicillin and α-Formylthiophene (αft)”, Journal of Chemistry, 2015; 12 pages.
K. S. Panday, A. S. Thakar, K. K. Singh, K. T. Joshi, and A. M. Pancholi, “Synthesis, Characterization and Antibacterial Activity of Schiff Bases and their Metal Complexes Derived from 4-Acyl-1-phenyl-3-methyl-2-pyrazolin-5-ones and 2-Amino-4(4’ methylphenyl) thiazole”, E-Journal of Chemistry, 2010; 7 (4): 1396-1406.
S. N. Kotkar and H. D. Juneja, “Synthesis, Characterization, and Antimicrobial Studies of N, O Donor Schiff Base Polymeric Complexes”, Journal of Chemistry, 2013; 5 pages.
C. A. Bolos, G. S. Nikolov, L. Ekateriniadou, A. Kortsaris and D. A. Kyriakidis, “Structure-Activity Relationships for Some Diamine, Triamine and Schiff Base Derivatives and their Copper (II) Complexes”, Metal-Based Drugs, 1998; 5 (6): 323-332.
Z. H. Chohan and S. Kausar, “Synthesis, Characterization and Biological Properties of Tridentate NNO, NNS and NNN Donor Thiazole Derived Furanyl, Thiophenyl”, Metal-Based Drugs, 2000; 7 (1): 17-22.
K. S. Kumar, V. K. Chityala, N. J. P. Subhashini, Y. Prashanthi and Shivaraj, “Synthesis, Characterization, and Biological and Cytotoxic Studies of Copper(II), Nickel(II), and Zinc(II) Binary Complexes of 3-Amino-5-methyl Isoxazole Schiff Base”, ISRN Inorganic Chemistry, 2013; 7 pages.
R. Rajavel, M. Senthil, Vadivu and C. Anitha, “Synthesis, Physical Characterization and Biological Activity of Some Schiff Base Complexes”, E-Journal of Chemistry, 2008; 5 (3): 620-626.
Z. H. Chohan, A. Munawar and C. T. Supuran, “Transition Metal ion Complexes of Schiff-Bases. Synthesis, Characterization and Antibacterial Properties”, Metal Based Drugs, 2001; 8 (3): 137-143.
A. K. Mapari, M. S. Hate and K. V. Mangaonkar, “Synthesis, Characterization and Antimicrobial Activity of Mixed Schiff Base Ligand Complexes of Co(II), Ni(II), Cu(II) and Zn(II)”, E-Journal of Chemistry, 2011; 8 (3): 1258-1263.
P. Jogi, K. Mounika, M. Padmaja, M. Lakshmi and C. Gyanakumari, “Synthesis, Characterization and Antibacterial Studies of Some Transition Metal Complexes of a Schiff Base Derived from 2-(Aminomethyl)-benzimidazole and Thiophene-2-carbaxaldehyde”, E-Journal of Chemistry, 2011; 8 (4): 1662-1669.
Z. H. Chohan, M. Praveen and A. Ghaffar, “Structural and Biological Behaviour of Co(II), Cu(II) and Ni(II) Metal Complexes of Some Amino Acid Derived Schiff-Base Ligands”, Metal Based Drugs, 1997; 4 (5): 267-272.
M. M. Hossain, M. A. Bashar, M. N. Khan, P. K. Roy, M. S. Ali, M. A. Farooque, “Preparation, Physical Characterization and Antibacterial Activity of Ni(II), Cu(II), Co(II), Cd(II), Zn(II) and Cr(III) Schiff Base Complex Compounds”, Science Journal of Chemistry, 2018; 6 (2): 17-23.
K. Siddappa, S. B. Mane and D. Manikprabhu, “Spectral Characterization and 3D Molecular Modeling Studies of Metal Complexes Involving the O, N-Donor Environment of Quinazoline-4(3H)-one Schiff Base and Their Biological Studies”, The Scientific World Journal, 2014; 13 pages.
A. S. Thakar, K. S. Pandya, K. T. Joshi & A. M. Pancholi, “Synthesis, Characterization and Antibacterial Activity of Novel Schiff Bases Derived from 4-Phenyl-2-aminothiazole and their Mn(II), Fe(II), Co(II), Ni(II) and Cu(II) Metal complexes”, E-Journal of Chemistry, 2011; 8 (4): 1556-1565.
I. P. Ejidike and P. A. Ajibade, “Synthesis, Characterization, Antioxidant, and Antibacterial Studies of Some Metal(II) Complexes of Tetradentate Schiff Base Ligand: (4E)-4-[(2-{(E)-[1-(2,4-Dihydroxyphenyl)ethylidene]amino}ethyl)imino]pentan-2-one”, Bioinorganic Chemistry and Applications, 2015; 9 pages.
A. Reiss, M. C. Chifiriuc, E. Amzoiu and C. I. Spînu, “Transition Metal(II) Complexes with Cefotaxime-Derived Schiff Base: Synthesis, Characterization, and Antimicrobial Studies”, Bioinorganic Chemistry and Applications, 2014; 17 pages.
Z. H. Chohan, “Biologically Active Transition Metal Chelates of Ni(II), Cu(II) and Zn(II) with 2-Aminothiazole-Derived Schiff-Base Ligands Their Synthesis, Characterization and The Role of Anions (NO3-, SO42-, C2O42- and CH3CO2-) on Their Antibacterial Properties”, Metal-Based Drugs, 1999; 6 (3): 187-192.
S. H. S. Saleem, M. Sankarganesh, P. R. A. Jose, K. Sakthikumar, L. Mitu and J. D. Raja, “Investigation of Antimicrobial, Antioxidant, and DNA Binding Studies of Bioactive Cu(II), Zn(II), Co(II), and Ni(II) Complexes of Pyrimidine Derivative Schiff Base Ligand”, Journal of Chemistry, 2017; 8 pages.
H. G. Aslan, S. Akkoç, Z. Kökbudak, L. Aydın, “Synthesis, characterization, and antimicrobial and catalytic activity of a new Schiff base and its metal(II) complexes”, J. Iran Chem. Soc., 2017; 14: 2263–2273.
S. Bal, B. Orhan, J. D. Connolly, M. Dıgrak and S. Koytepe, “Synthesis and characterization of some Schiff bases, their metal complexes and thermal, antimicrobial and catalytic features”, J Therm Anal Calorim, 2015; 9 pages.
V. V. Dhayabaran, T. D. Prakash, R. Renganathan, E. Friehs and D. W. Bahnemann, “Novel Bioactive Co(II), Cu(II), Ni(II) and Zn(II) Complexes with Schiff Base Ligand Derived from Histidine and 1,3-Indandione: Synthesis, Structural Elucidation, Biological Investigation and Docking Analysis”, J Fluoresc, 2016; 16 pages.
A. B. Gündüzalp and H. F. Özbay, “The Synthesis, Characterization and Antibacterial Activities of Dinuclear Ni(II), Cu(II) and Fe(III) Schiff Base Complexes”, Russian Journal of Inorganic Chemistry, 2012; 57 (2): 257–260.
N. K. Chaudhary and P. Mishra, “In Vitro Antimicrobial Screening of Metal Complexes of Schiff Base derived from Streptomycin and Amoxicillin: Synthesis, Characterization and Molecular Modelling”, American Journal of Applied Chemistry, 2014; 2 (1): 19-26.
M. N. Uddin, D. A. Chowdhury, M. M. Rony, M. E. Halim, “Metal Complexes of Schiff Bases Derived from 2-Thiophenecarboxaldehyde and Mono/Diamine as the Antibacterial Agents”, Modern Chemistry, 2014; 2 (2): 6-13.
N. Raman, S. J. Raja, J. Joseph, and A. Sakthivel, “Designing, Structural Elucidation, Comparison of DNA Cleavage, and Antibacterial Activity of Metal(II) Complexes Containing Tetradentate Schiff Base”, Russian Journal of Coordination Chemistry, 2008; 34 (11): 842–848.
A. Reiss, M. C. Chifiriuc, E. Amzoiu, N. Cioatera, I. Dabuleanu and P. Rotaru, “New metal(II) complexes with ceftazidime Schiff base”, J Therm Anal Calorim, 2018; 131: 2073–2085.
R. P. Saini, V. Kumar, A. K. Gupta and G. K. Gupta, “Synthesis, characterization, and antibacterial activity of a novel heterocyclic Schiff’s base and its metal complexes of first transition series”, Med. Chem. Res., 2014; 23: 690–698.
V. Reddy, N. Patil and S. D. Angadi, “Synthesis, Characterization and Antimicrobial Activity of Cu(II), Co(II) and Ni(II) Complexes with O, N, and S Donor Ligands”, E-Journal of Chemistry, 2008; 5 (3); 577-583.
C. Anitha, S. Sumathi, P. Tharmaraj and C. D. Sheela, “Synthesis, Characterization, and Biological Activity of Some Transition Metal Complexes Derived from Novel Hydrazone Azo Schiff Base Ligand”, International Journal of Inorganic Chemistry, 2011; 8 pages.
M. M. Haque, M. Kudrat-E-Zahan, L. A. Banu, M. Shariful Islam, and M. Saidul Islam, “Synthesis and Characterization with Antineoplastic, Biochemical, Cytotoxic, and Antimicrobial Studies of Schiff Base Cu(II) Ion Complexes”, Bioinorganic Chemistry and Applications, 2015; 7 pages.
G. Kumar, A. Kumar, N. Shishodia, Y. P. Garg and B. P. Yadav, “Synthesis, Spectral Characterization and Antimicrobial Evaluation of Schiff Base Cu(II), Ni(II) and Co(II) Novel Macrocyclic Complexes”, E-Journal of Chemistry, 2011; 8 (4): 1872-1880.
K. Rathore, R. K. R. Singh and H. B. Singh, “Structural, Spectroscopic and Biological Aspects of O, N- Donor Schiff Base Ligand and its Cr(III), Co(II), Ni(II) and Cu(II) Complexes Synthesized through Green Chemical Approach”, E-Journal of Chemistry, 2010; 7 (S1): S566-S572.
R. Jayarajan, G. Vasuki, and P. S. Rao, “Synthesis and Antimicrobial Studies of Tridentate Schiff Base Ligands with Pyrazolone Moiety and Their Metal Complexes”, Organic Chemistry International, 2010; 7 pages.
P. S. Mane, S. M. Salunke and B. S. More, “Synthesis and Structural Studies of Transition Metal Complexes with Bidentate Schiff Base Derived from 3-Acetyl-6-methyl-(2H)-pyran-2,4(3H)-dione”, E-Journal of Chemistry, 2011; 8 (S1): S245-S252.
K. R. Joshi, A. J. Rojivadiya, and J. H. Pandya, “Synthesis and Spectroscopic and Antimicrobial Studies of Schiff Base Metal Complexes Derived from 2-Hydroxy-3-methoxy-5-nitrobenzaldehyde”, International Journal of Inorganic Chemistry, 2014; 8 pages.
K. Singh, Y. Kumar, P. Puri, C. Sharma, and K. R. Aneja, “Metal-Based Biologically Active Compounds: Synthesis, Spectral, and Antimicrobial Studies of Cobalt, Nickel, Copper, and Zinc Complexes of Triazole-Derived Schiff Bases”, Bioinorganic Chemistry and Applications, 2011; 10 pages.
R. B. Sumathi and M. B. Halli, “Metal(II) Complexes Derived from Naphthofuran-2-carbohydrazide and Diacetylmonoxime Schiff Base: Synthesis, Spectroscopic, Electrochemical, and Biological Investigation”, Bioinorganic Chemistry and Applications, 2014; 11 pages.
A. A. Al-Amiery, “Synthesis and antioxidant, antimicrobial evaluation, DFT studies of novel metal complexes derivate from Schiff base”, Res Chem Intermed, 2012; 38: 745–759.
M. B. Halli and R. B. Sumathi, “Antimicrobial, DNA cleavage, and antioxidant properties of new series of metal(II) complexes derived from naphthofuran-2-carbohydrazide Schiff base: synthesis and physico-chemical studies”, Med Chem Res., 2014; 23: 2093–2105.
A. P. Mishra, R. K. Mishra, and M. D. Pandey, “Synthetic, Spectral, Structural and Antimicrobial Studies of Some Schiff Bases 3-d Metal Complexes”, Russian Journal of Inorganic Chemistry, 2011; 56 (11): 1757–1764.
N. Raman, A. Kulandaisamy and C. Thangaraja, “Redox and antimicrobial studies of transition metal(II) tetradentate Schiff base complexes”, Transition Metal Chemistry, 2003; 28: 29–36.
N. Raman, C. Thangaraja, S. Johnsonraja, “Synthesis, spectral characterization, redox and antimicrobial activity of Schiff base transition metal(II) complexes derived from 4-amino antipyrine and 3-salicylidene acetyl acetone”, Central European Journal of Chemistry, 2005; 3 (3): 537–555.
S. A. Patil, S. N. Unki, P. S. Badami, “In vitro antibacterial, antifungal, and DNA cleavage studies of coumarin Schiff bases and their metal complexes: synthesis and spectral characterization”, Med Chem Res, 2012; 21: 4017–4027.
N. Raman, J. D. Raja and A. Sakthivel, “Synthesis, spectral characterization of Schiff base transition metal complexes: DNA cleavage and antimicrobial activity studies”, J. Chem. Sci., 2007; 119 (4): 303–310.
N. Raman and A. Selvan, “Synthesis, Spectroscopic, Electrochemical, DNA Binding and Photocleavage Studies on Coordination Compounds of Bis(4-aminophenyl) methane Based Novel Schiff Bases”, Russian Journal of Inorganic Chemistry, 2011; 56 (5): 759–770.
A. M. Abu‑Dief, L. A. E. Nassr, “Tailoring, physicochemical characterization, antibacterial and DNA binding mode studies of Cu(II) Schiff bases amino acid bioactive agents incorporating 5‑bromo‑2‑hydroxybenzaldehyde”, Springer, J Iran Chem Soc., 2015; 12: 943–955.
M. N. Patel, C. R. Patel & H. N. Joshi, “Metal-Based Biologically Active Compounds: Synthesis, Characterization, DNA Interaction, Antibacterial, Cytotoxic and SOD Mimic Activities”, Appl Biochem Biotechnol, 2013; 169 :1329–1345.
Y. Li, Z. Y. Yang, M. F. Wang, “Synthesis, Characterization, DNA Binding Properties, Fluorescence Studies and Antioxidant Activity of Transition Metal Complexes with Hesperetin-2-hydroxy Benzoyl Hydrazone”, J Fluoresc, 2010; 20: 891–905.
C. Gokce, R. Gup, “Synthesis and characterisation of Cu(II), Ni(II), and Zn(II) complexes of furfural derived from aroyl hydrazones bearing aliphatic groups and their interactions with DNA”, Chemical Papers, 2013; 67 (10): 1293–1303.
P. Lavaee, H. E. Hosseini, M. R. Housaindokht, J. T. Mague, A. A. Esmaeili1 & K. Abnous, “Synthesis, Characterization and Fluorescence Properties of Zn(II) and Cu(II) Complexes: DNA Binding Study of Zn(II) Complex”, J Fluoresc, DOI 10.1007/s10895-015-1719-6.
M. P. Kesavan, G. G. V. Kumar, J. D. Raja, K. Anitha, S. Karthikeyan, J. Rajesh, “DNA interaction, antimicrobial, antioxidant and anticancer studies on Cu(II) complexes of Luotonin A”, Journal of Photochemistry & Photobiology, B: Biology, 2017; 167: 20–28.
S. B. Moosun, S. J. Laulloo, E. C. Hosten, T. I. A. Gerber, M. G. Bhowon, “Antioxidant and DNA binding studies of Cu(II) complexes of N,N0-(1,10-dithio-bis(phenylene))-bis(salicylideneimine): synthesis and characterization”, Transition Met Chem, 2015; 40: 445–458.
Q. Zhou and P. Yang, “Crystal structure and DNA-binding studies of a new Cu(II) complex involving benzimidazole”, Inorganica Chimica Acta, 2006, 359 (4):1200-1206.
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