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Antibacterial Effects and Synthesized New Derivatives of 4-Hydroxy-Chromen-2-One
American Journal of Heterocyclic Chemistry
Volume 5, Issue 1, March 2019, Pages: 7-10
Received: Jan. 28, 2019; Accepted: Mar. 21, 2019; Published: Apr. 15, 2019
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Aziz Behrami, Department of Food Technology, University of Mitrovica “Isa Boletini”, Mitrovica, Kosova
Florent Dobroshi, Department of Food Technology, University of Mitrovica “Isa Boletini”, Mitrovica, Kosova
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In present paper, we report the organic syntheses of three compounds exactly 4-hydroxy-chromen-2-one and describe the results of antibacterial activity of purified compounds. Compounds 4-(4-Methoxy-phenylamino)-2-oxo-2H-chromene-3-sulfonyl chloride (a). N-{3-[Diethoxy-(2-hydroxy-phenyl)-methyl]-2-oxo-2H-chromen-4-yl}-acetamide (b), 4-(6-Nitro-benzothiazol-2-ylamino)-2-oxo-2H-chromene-3-carbaldehyde (c), have been synthesized and characterized using melting points, IR spectra, 1H-NMR and 13C-NMR spectra. Our research goal is synthesis novel organic compounds which prove high level of antibacterial activity. The antibacterial activity of synthesized compounds and streptomycin and cefalexine at concentrations of 2mg/ml, 3mg/ml and 5mg/ml, have been evaluated against three strains of bacterial culture; Staphylococcus aureus, E. coli and Bacillus cereus. The compounds show bacteriostatic and bactericidal activity in high level and also synthetized compounds has been characterized using advanced instrumental methods of analysis.
Coumarine Derivatives, Antibacterial Activity, IR, 1H-NM, 13C-NMR, Streptomycine
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Aziz Behrami, Florent Dobroshi, Antibacterial Effects and Synthesized New Derivatives of 4-Hydroxy-Chromen-2-One, American Journal of Heterocyclic Chemistry. Vol. 5, No. 1, 2019, pp. 7-10. doi: 10.11648/j.ajhc.20190501.13
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This article is an open access article distributed under the Creative Commons Attribution License ( which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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