Fatty Acids in Heterocyclic Synthesis: Part XIX Synthesis of Some Isoxazole, Pyrazole, Pyrimidine and Pyridine and Their Surface, Anticancer and Antioxidant Activities
American Journal of Heterocyclic Chemistry
Volume 4, Issue 2, June 2018, Pages: 30-41
Received: Mar. 12, 2018; Accepted: Apr. 11, 2018; Published: Jul. 3, 2018
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Authors
Abdelmotaal Abdelmajeid, Chemistry Department, Faculty of Science, Benha University, Benha, Egypt
Mahasen Saad Amine, Chemistry Department, Faculty of Science, Benha University, Benha, Egypt
Reda Ali Hassan, Chemistry Department, Faculty of Science, Benha University, Benha, Egypt
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Abstract
Acryloylphenylstearamide (2) was utilized as a starting material for synthesis the titled compounds via one-pot synthesis. Compound (2) was reacted with hydroxylamine hydrochloride in pyridine and produced isooxazole (3), and with thiosemicarbazide in pyridine and/or hydrazine-hydrate in ethanol afforded pyrazoles (4), and (5), while the reaction of (2) with urea and/ or thiourea in an alcoholic solution of sodium ethoxide gave pyrimidinone (6) and pyrimidinedione (7). Also, reaction of (2) with acetylacetone and/or ethyl acetoacetate in acetic acid andammonium acetateafforded Pyridine derivatives (8), and (9) respectively. Addition of different amounts of propylene oxide (3, 5, 7 moles) to the synthesized compounds produced nonionic surfactants (2-9a-c). The physiochemical and surface active properties of the prepared surfactant as surface and interfacial tension, cloud point, wetting time, emulsion stability, foam height, CMC, resistance to hydrolysis and their biodegradability were investigated. Also, the surface parameters as effectiveness (πCMC), efficiency (PC20), maximum surface excess (Γmax) and (Amin) were evaluated.
Keywords
Stearoyl Chloride, P-Aminoacetophenone, Nonionic Surfactant, Propylene Oxide
To cite this article
Abdelmotaal Abdelmajeid, Mahasen Saad Amine, Reda Ali Hassan, Fatty Acids in Heterocyclic Synthesis: Part XIX Synthesis of Some Isoxazole, Pyrazole, Pyrimidine and Pyridine and Their Surface, Anticancer and Antioxidant Activities, American Journal of Heterocyclic Chemistry. Vol. 4, No. 2, 2018, pp. 30-41. doi: 10.11648/j.ajhc.20180402.11
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Copyright © 2018 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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