The Advances and Applications of Arynes and Their Precursors to Synthesize the Heterocyclic Compounds: A Review
American Journal of Heterocyclic Chemistry
Volume 3, Issue 5, October 2017, Pages: 47-54
Received: Sep. 6, 2017; Accepted: Sep. 21, 2017; Published: Oct. 23, 2017
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Authors
Md. Ashraful Alam, Department of Chemistry and Bioengineering, Iwate University, Morioka, Japan
Kazuaki Shimada, Department of Chemistry and Bioengineering, Iwate University, Morioka, Japan
Aklima Jahan, Department of Chemistry, University of Chittagong, Chittagong, Bangladesh
Dina Nasrin, Department of Chemistry, Bangladesh University of Engineering and Technology (BUET), Dhaka, Bangladesh
Md. Kudrat-E-Zahan, Department of Chemistry, University of Rajshahi, Rajshahi, Bangladesh
Mohammad Shahabuddin, Department of Chemistry, Shahjalal University of Science and Technology (SUST), Sylhet, Bangladesh
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Abstract
The aryne and its intermediates or their precursors are the most important compounds in organic synthesis for the purpose of arynes or benzyne insertion in many reactions. Arynes are among the first reactive intermediates known to organic chemists. Since their discovery, they have fascinated chemists from both theoretical and synthetic perspectives. These remarkable intermediates possess a wide reactivity profile, engaging in the different types of reactions especially in organic chemistry fields like nucleophilic addition reactions, pericyclic reactions, [4+2] and [3+2] cycloaddition reactions and transition metal-mediated/catalyzed reactions. This methodology would also be applicable for the synthesis of biologically and pharmaceutically active products such as isocoumarins, benzodiazepines and other important compounds in one pot reactions.
Keywords
Arynes, Benzyne, Cycloaddition Reactions, Heterocycles, Isocoumarins, Nucleophilic Reactions, Pericyclic Reactions
To cite this article
Md. Ashraful Alam, Kazuaki Shimada, Aklima Jahan, Dina Nasrin, Md. Kudrat-E-Zahan, Mohammad Shahabuddin, The Advances and Applications of Arynes and Their Precursors to Synthesize the Heterocyclic Compounds: A Review, American Journal of Heterocyclic Chemistry. Vol. 3, No. 5, 2017, pp. 47-54. doi: 10.11648/j.ajhc.20170305.11
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Copyright © 2017 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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