Spectroscopic Identification and Synthesis of Derivatives of Pyrimidine 2- Thione Via Two Different Spacers
American Journal of Heterocyclic Chemistry
Volume 2, Issue 1, December 2016, Pages: 8-12
Received: Oct. 28, 2016; Accepted: Nov. 12, 2016; Published: Dec. 10, 2016
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Authors
Moayed J. Mohammed, Department of Chemistry, College of Education for pure Science, University of Mosul, Mosul, Iraq
Ahmed Kh. Ahmed, Department of Chemistry, College of Education for pure Science, University of Mosul, Mosul, Iraq
Faris T. Abachi, Department of Pharmaceutical Chemistry, College of Pharmacy, University of Mosul, Mosul, Iraq
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Abstract
A new series of pyrimidine -2-thione derivatives were synthesized via two routes and designated as antifolate. The heterocyclic ring was prepared by direct reaction of benzoyl acetone with thiosemicarbiazide in acidic medium. Also, the pyrimidine-2-thione ring reacts with p-aminobenzoic acid to form 4-amino-N-(4-methyl-6-phenyl)-2-thioxypyrimidine 1[2H] –yl benzamide. The second route synthesis 5-[{4-methyl-6-phenyl-2-thioxo pyridine-1-yl amino}-4-(4-methyl phenylsulfonamido)-5-oxobenzoyl] pentanoic acid. All structures were elucidate by their physical & spectroscopic data FTIR, 1H &13C NMR.
Keywords
Antifolate, P-aminobenzoic Acid, Pyrimidine, NMR
To cite this article
Moayed J. Mohammed, Ahmed Kh. Ahmed, Faris T. Abachi, Spectroscopic Identification and Synthesis of Derivatives of Pyrimidine 2- Thione Via Two Different Spacers, American Journal of Heterocyclic Chemistry. Vol. 2, No. 1, 2016, pp. 8-12. doi: 10.11648/j.ajhc.20160201.12
Copyright
Copyright © 2016 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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