Synthesis of β-Receptor Blocker and Antihypertensive Drug Using (SBA-Pr-SO3H) as an Eco-Friendly, Inexpensive and Efficient Nano-Catalyst
American Journal of Heterocyclic Chemistry
Volume 1, Issue 1, April 2015, Pages: 1-5
Received: Apr. 10, 2015; Accepted: Apr. 22, 2015; Published: Apr. 28, 2015
Views 5343      Downloads 199
Ali Gharib, Department of Chemistry, Islamic Azad University, Mashhad, Iran; Department of Chemistry, Agricultural Researches and Services Center, Mashhad, Iran
Nader Noroozi Pesyan, Department of Chemistry, Faculty of Science, Urmia University, Urmia, Iran
Leila Vojdani Fard, Education Ministry, Education Organization of Razavi Khorasan, Mashhad, Iran
Mina Roshani, Department of Chemistry, Islamic Azad University, Mashhad, Iran
Article Tools
Follow on us
In this method, at first the synthesis of 2,3-dihydro-1H-carbazol-4(9H)-one product by the condensation of (Z)-3-(2-phenylhydrazono)cyclohexanone in the presence of (SBA-Pr-SO3H) as nanoporous solid acid catalyst, acid acetic glacial and ethanol as solvent under reflux conditions is reported. (SBA-Pr-SO3H) nanoporous solid acid catalyst was used as an effective catalyst for the synthesis of Carvedilol from the reaction of 4-oxiranylmethyoxy-9H-carbazole and 2-(2-methoxyphenoxy)ethanamine in the presence of monoglyme solvent. This synthesis afforded under ring opening of 4-oxiranylmethyoxy-9H-carbazole with 2-(2-methoxyphenoxy)ethanamine by above nano-catalyst. Heterogeneous reaction conditions, easy procedure, short reaction time, and high yields are some important advantages of this method.
Carvedilol, Nano-Catalyst, Carbazole, Heterogeneous, (SBA-Pr-SO3H), Synthesis
To cite this article
Ali Gharib, Nader Noroozi Pesyan, Leila Vojdani Fard, Mina Roshani, Synthesis of β-Receptor Blocker and Antihypertensive Drug Using (SBA-Pr-SO3H) as an Eco-Friendly, Inexpensive and Efficient Nano-Catalyst, American Journal of Heterocyclic Chemistry. Vol. 1, No. 1, 2015, pp. 1-5. doi: 10.11648/j.ajhc.20150101.11
J. N. Joyce, N. Lexow, S. J. Kim, R. Artymyshyn, S. Senzon, D. Lawrence, M. F. Cassanova, J. R. Kleinman, E. D. Bird, A. Winokur, Synapse. 1992, 10, 228.
L. M. Kukin; J. Kalman; H. R. Charney; K. D. Levy; C. Buchholz-Varely; N. O. Ocampo;C. Eng, Circulation. 1999, 99, 2645.
M. Packer, B. M. Fowler, B. E. Roecker, J. S. A. Coats, A. H. Katus, H. Krum, P. Mohacsi, L. J. Rouleau, M. Tendera, C. Staiger, L. T. Holcslaw, I. Amann-Zalah, L. D. DeMets, Circulation. 2002, 106, 2194.
S. Beck, J. C. Vartuli, W. J. Roth, C. T. Kresge, M. E. Leonowicz, K. D. Schmitt, C.T-W Chu, D. H. Olson, E. W. Sheppard, S. B. McCullen, J. B. Higgins, J. L. Schlenker, J. Am. Chem. Soc. 1992, 114, 10834.
P. Reinert, B. Garcia, C. Morin, A. Badiei, P. Perriat, O. Tillement, L. Bonneviot, Stud. Surf. Sci. Catal. 2003, 146, 133.
D. Zhao, Q. Huo, J. Feng, B. F. Chmelka, G. D. Stucky, J. Am. Chem. Soc. 1998, 120, 6024.
D. Trong On, D. Desplantier-Giscard, C. Danumah, S. Kaliaguine, Appl. Catal. A: Gen. 2001, 222, 299.
M. R. Ganjali, A. Daftari, L. Hajiagha Babaei, K. Saberyan, G. Mohammadi Ziarani, A. Moghimi, Water, Air, Soil Pollut. 2006, 173, 71.
A. Badiei, P. Norouzi, F. Tousi, Eur. J. Sci. Res. 2005, 12, 39.
M. H. Lim, C. F. Blanford, A. Stein, Chem. Mater. 1998, 10, 467.
M. Onaka, N. Hashimoto, Y. Kitabata, R. Yamasaki, Appl. Catal. A: General. 2003, 241, 307.
R. I. Kureshy, I. Ahmad, K. Pathak, N. H. Khan, S. H. R. Abdi, R. V. Jasra, Catal. Commun. 2009, 10, 572.
B. Karimi, D. Zareyee, Org. Lett. 2008, 10, 3989.
A. Gharib, N. N. Pesyan, B. R. H. Khorasani, M. Roshani, J. (HANS) W. Scheeren, Bulgarian Chemical Communications. 2013, 45, 371.
A. Liu, G. Lu, Acta Pharmaceutica Sinica, 1994, 29, 793.
G. M. Ziarani, A. Badiei, Y. Khaniania, Iranian Journal of Chemistry and Chemical Engineering, 2010, 29, 1.
Science Publishing Group
1 Rockefeller Plaza,
10th and 11th Floors,
New York, NY 10020
Tel: (001)347-983-5186