Anti-diabetic Effect of Myrtenal on Plasma and Tissue Glycoproteins Components in STZ Induced Experimental Diabetic Rats
Journal of Diseases and Medicinal Plants
Volume 2, Issue 1-1, February 2016, Pages: 11-16
Received: Aug. 14, 2015; Accepted: Sep. 1, 2015; Published: Feb. 23, 2016
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Authors
Leelavinothan Pari, Phytopharmacology and Molecular Biology Research Laboratory Annamalai University, Annamalainagar Tamilnadu, India; Department of Biochemistry & Biotechnology Faculty of Science, Annamalai University, Annmalainagar, Tamilnadu, India
Ayyasamy Rathinam, Phytopharmacology and Molecular Biology Research Laboratory Annamalai University, Annamalainagar Tamilnadu, India
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Abstract
The aim of present study was to evaluate the effect of myrtenal, a monoterpene on plasma and tissues glycoprotein components in streptozotocin-induced diabetic rats. Diabetes was induced in overnight fasted experimental rats by a single intraperitoneal injection of streptozotocin (STZ; 40 mg/kg body weight) dissolved in 0.1 M citrate buffer at pH 4.5. STZ-injected animals were given 20 % glucose solution for 24 h to prevent initial drug-induced hypoglycemia mortality. The levels of plasma glucose, plasma and tissues glycoproteins such as hexose, hexosamine, fucose and sialic acid were significantly increased whereas plasma insulin levels were significantly decreased in diabetic rats. On oral administration myrtenal (80 mg/kg b.w.) once daily to diabetic rats for the period of 28 days brought back the levels of plasma and tissues glycoprotein components. Based on the present study, we propose that myrtenal possesses significant protective effect on glycoprotein metabolism.
Keywords
Myrtenal, Glycoproteins, Wistar Rat, Streptozotocin, Hyperglycemia
To cite this article
Leelavinothan Pari, Ayyasamy Rathinam, Anti-diabetic Effect of Myrtenal on Plasma and Tissue Glycoproteins Components in STZ Induced Experimental Diabetic Rats, Journal of Diseases and Medicinal Plants. Special Issue: Pharmacological Action of Medicinal Plants: Health and Diseases. Vol. 2, No. 1-1, 2016, pp. 11-16. doi: 10.11648/j.jdmp.s.2016020101.12
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