Review on Ethnomedicinal and Pharmacological Uses of Echinops kebericho Mesfin in Ethiopia
Journal of Diseases and Medicinal Plants
Volume 5, Issue 5, October 2019, Pages: 78-86
Received: Sep. 4, 2019; Accepted: Oct. 4, 2019; Published: Nov. 13, 2019
Views 607      Downloads 218
Gadisa Demie, Forestry Department, College of Agriculture and Veterinary Science, Ambo University, Ambo, Ethiopia
Article Tools
Follow on us
The genus Echinops is native to African countries, the Middle East, Europe, and Asia comprises 120 species. In Ethiopia, this genus is represented by well known endemic and critically endangered species Echinops kebericho Mesfin also known as “ Kebercho,” in Amharic language which has a long history of ethnomedicinal uses. Due to the popularity of species as a source of ethnomedicine, this species is severely over-harvested throughout their distributional ranges. This review documents fragmented information on traditional uses and pharmacological evidence of Echinops kebericho in Ethiopia. This review article was carried out by searching studies in PubMed, Google scholar and Google search up to August 2019. The search terms were “Echinops kebericho Mesfin”, “therapeutic” & “pharmacological”. Ethnomedicinal uses of Echinops kebericho Mesfin has been recorded from different regions of Ethiopia for 32 human and 2 livestock ailments. E. kebericho is used to treat evil eye, headache, cough, stomachache, febrile illness and malaria ailments. The extracts of E. kebericho, particularly those from root, exhibited a wide range of pharmacological effects including antihelminthic, antibacterial, antifungal, antidiarrheal, anti spasmolytic and antimalarial activities. These pharmacological studies have established a scientific basis for therapeutic uses of Echinops kebericho Mesfin. Although Ethiopian Echinops kebericho is widely used by traditional practitioners but, it is threatened due to over exploitation of root part. Therefore, E. kebericho need urgent conservation attention, micro propagation, effective documentation and further research.
Echinops kebericho Mesfin, Ethnomedicinal, Pharmacology
To cite this article
Gadisa Demie, Review on Ethnomedicinal and Pharmacological Uses of Echinops kebericho Mesfin in Ethiopia, Journal of Diseases and Medicinal Plants. Vol. 5, No. 5, 2019, pp. 78-86. doi: 10.11648/j.jdmp.20190505.12
Copyright © 2019 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License ( which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Dolatkhahi, M., Dolatkhahi, A., Nejad, JB. (2014): Ethnobotanical study of medicinal plants used in Arjan–Parishan protected area in Fars Province of Iran. Avicenna J Phytomed, 4: 402–12.
Shendye, NV., Gurav, SS. (2014): Cynodon dactylon: A Systemic Review of Pharmacognosy, Phytochemistry and Pharmacology. Int J Pharm Pharm Sci 8: 7-12.
Shah, A., Marwat, SK., Gohar, F., Khan, A., Bhatti, KH., Amin, M. (2013): Ethnobotanical study of medicinal plants of semi-tribal area of Makerwal & Gulla Khel (lying between Khyber Pakhtunkhwa and Punjab Provinces), Pakistan. Am J Plant Sci, 4: 98–116.
Hostettmann, K., Marston, A., Ndjoko, K., Wolfender, J-L. (2000): The Potential of African Medicinal Plants as a Source of Drugs. Current Organic Chemistry, 4: 973-1010.
Gidey, M., Beyene, T., Signorini, MA., Bruschi, P., Yirga, G. (2015): Traditional medicinal plants used by Kunama ethnicgroup in Northern Ethiopia. Journal of Medicinal Plants Research15: 94-509.
Lulekal, E., Kelbessa, E., Bekele, T., Yineger, H. (2008): An ethnobotanical study of medicinal plants in Mana AngetuDistrict, southeastern Ethiopia. Journal of Ethnobiology and Ethnomedicine, 4: 10.
Yassin, S., Abera, B., Kelbessa, E. (2015): Ethnobotanical study of indigenous knowledge of plant-material culture in Masha and Yeki Districts, Southwest Ethiopia. Afr J Plant Sci 9: 25-49.
Hunde, D., Jesse, T., Asfaw, Z., Nyangito, MM. (2011): Wild edible fruits of importance for human nutrition in semiarid parts of East Shewa zone, Ethiopia: associated indigenous knowledge and implications to food security. J. Nutr, 10: 40–50.
Bekele, E. (2007): Study on Actual Situation of Medicinal Plants in Ethiopia; 77. Available from 〈〉.
Bahmani, M., Rafieian-Kopaei, M., Avijgan, M., Hosseini, S., Golshahi, H., Eftekhari, Z. (2012): Ethnobotanical studies of medicinal plants used by Kurdish owner’s in south range of Ilam province, west of Iran. Am Eurasia J Agric Environ Sci, 12: 1128–33.
Savithramma, N., Ankanna, S., Linga, RM., Saradvathi, J. (2012): Studies on antimicrobial efficacy of medicinal tuberous shrub Talinum cuneifolium. J Environ Biol 33: 775–80.
Deka, M., Kalita, JC., Sarma, GC. (2011): Traditional use of fertility inducing plants used by the herbal practitioners in some parts of the state Assam, N E India, a survey report. International Journal of Science and Advanced Technology, 1: 133–142.
Robert, H., John, B. (1983): Traditional medicine and health carecoverage. WHO; 1983.
Belay, G., Tariku, Y., Kebede, T., Hymete, A., Mekonnen, Y. (2011): Ethnopharmacological Investigations of Essential Oils Isolated from Five Ethiopian Medicinal Plants against Eleven Pathogenic Bacterial Strains. Phytopharmacology, 1: 133-143.
Toma, A., Deyno, S., Fikru, A., Eyado, A., Beale, A. (2015): In vivo antiplasmodial and toxicological effect of crude ethanol extract of Echinops kebericho traditionally used in treatment of malaria in Ethiopia. Malaria Journal 14: 196.
Abegaz, B., Mutanyatta-Comar, J., Nindi, M. (2007): Naturally Occurring Homoiso flavonoids: Phytochemistry, Biological Activities and Synthesis. Natural Product Communications 2: 475-498.
Tariku, Y., Hymete, A., Hailu, A., Rohloff, J. (2011): In Vitro Evaluation of Antileishmanial Activity and Toxicity of Essential Oils of Artemisia absinthium and Echinops kebericho. Chemistry &Biodiversity8: 614-623.
Hymete, A., Rohloff, J., Iversen, TH., Kjosen, H. (2007): Volatile Constituents of the Roots of Echinops kebericho Mesfin. Fla. and Fragr J22: 35-38.
Jemal, H., Kaba, U., Fayissa, R., Awol, J., Sultan, A., Nazif, H. (2011): Antihelmentic Effects of the Essential Oil Extracts of Selected Medicinal Plants against Haemonchus contortus. International Journal of Agricultural Research6: 290-298.
Bekalo, TH., Woodmatas, SD., Woldemariam, ZA. (2009): Anethnobotanical study of medicinal plants used by localpeople in the lowlands of Konta Special Woreda, southern nations, nationalities and peoples regionalstate, Ethiopia. J. Ethnobiol Ethnomed 5: 26 doi: 10.1186/1746-4269-5-26.
Wondimu, T., Asfaw, Z., Kelbessa, E. (2007): Ethnobotanical study of medicinal plants around‘Dheeraa’ town, Arsi Zone, Ethiopia Journal of Ethnopharmacology 112: 152–161.
Getachew, B., Yinebeb, T., Taddesse, K., Ariaya, H., Yalemtsehay, M. (2011): Ethnopharmacological Investigations of Essential Oils Isolated from Five Ethiopian Medicinal Plants against Eleven Pathogenic Bacterial Strains. Phytopharmacology, 1: 133-143.
Demissew, S. (1993): Description of some essential oil bearing plants in Ethiopia and their indigenous uses. J Essent Oil Res, 5: 465-479.
Ayalew, S., Kebede, A., Mesfin, A., Mulualem, G. (2017): Ethnobotanical study of medicinal plants used by agropastoralist Somali people for the management ofhuman ailments in Jeldesa Cluster, Dire DawaAdministration, Eastern Ethiopia. J. Med. Plants Res, 9: 171-187.
Desta, B. (1995): Ethiopian traditional herbal drugs. Part I: Studies on the toxicity and therapeutic activity of local taenicidal medications. Journal of Ethnopharmacology, 45: 27-33.
Enyew, A., Asfaw, Z., Kelbessa, E., Nagappan, R. (2014): Ethnobotanical Study of Traditional Medicinal Plants in and Around Fiche District, Central Ethiopia. Curr. Res. J. Biol. Sci, 4: 154-167.
Kassa, Z., Asfaw, Z., Demissew, S. (2016): Ethnobotanical study of medicinal plants used by thelocal people in Tulu Korma and its Surrounding Areas of Ejere District, Western Shewa Zone ofOromia Regional State, Ethiopia. JMPS, 2: 24-47.
Megersa, M., Asfaw, Z., Kelbessa, E., Beyene, A., Woldeab, B. (2013): An ethnobotanical study of medicinal plants in Wayu Tuka District, East Welega Zone of Oromia Regional State, West Ethiopia. Journal of Ethnobiology and Ethnomedicine, 9: 68.
Tadesse, M., Mesfin, B. (2010): A review of selected plants used in the maintenance of health and wellness in Ethiopia. Ethiopiane-journal Research & Innovation foresight 1: 85-102.
Tekle, Y. (2014): An ethno-veterinary botanical survey of medicinal plants in Kochore district of Gedeo Zone, Southern Nations Nationalities and Peoples Regional State (SNNPRs), Ethiopia. JSIR, 4: 433-445.
Abera, B. (2014): Medicinal plants used in traditional medicine byOromo people, Ghimbi District, Southwest Ethiopia. Journal of Ethnobiology and Ethnomedicine 10: 40.
Asmamaw, D., Achamyeleh, H. (2018): Assessment of Medicinal Plants and Their Conservation Status in Case ofDaligaw Kebela, Gozamen Werda, East Gojjam Zone. J Biodivers Bio, 1: 170.
Gebeyehu, G., Asfaw, Z., Enyew, A., Raja, N. (2014): Ethnobotanical study of traditional medicinal plants and their conservation status in Mecha wereda, West Gojjam zone of Ethiopia. Int. J. Pharm. & H. Care Res, 03: 137-154.
Getnet, Z., Chandrodyam, S., Masresha, G. (2016): Studies on traditional medicinal plants in Ambagiorgis area of Wogera District, Amhara Regional State, Ethiopia. Int. J. Pure App. Biosci, 4: 38-45.
Lulekal, E., Asfaw, Z., Kelbessa, E., Damme, PV. (2013): Ethnomedicinal study of plants used for human ailments in Ankober District, North Shewa Zone, Amhara Region, Ethiopia. J Ethnobiol Ethnomed 9: 63.
Regassa, R. (2013): Assessment of indigenous knowledge of medicinal plant practice and mode of service delivery in Hawassa city, southern Ethiopia. Journal of Medicinal Plants Research, 9: 517-535.
Wubetu, M., Abula, T., Dejenu, G. (2017): Ethnopharmacologic survey of medicinal plants used to treat human diseases by traditional medical practitioners in Dega Damot district, Amhara, Northwestern Ethiopia. BMC Res 10: 157 DOI 10.1186/s13104-017-2482-3.
Yigezu, Y., Berihun, D., Yenet, W. (2014):. Ethnoveterinary medicines in four districts of Jimma zone, Ethiopia: cross sectional survey for plant species and mode of use. BMC Veterinary Research 10: 76.
Hedberg, I., Friis, I., Edwards, S. (2004): Flora of Ethiopia and Eritrea. Vol. 4, part 2’, Addis Ababa University, Addis Ababa 221–223.
Teresa, G., Susanna, A., Garcia-jacas, N., Vilatersana, R., Vall, J. (2005): A first approach to the molecular phylogeny of the genus Echinops (asteraceae): sectional delimitation and relationships with the genus, Acantholepis. Fotia Geobotanica 40: 407-419.
Erko, B. (2006): Screening of Echinops ellenbeki and E. longisetus for biological activities and chemical constitutes. [C] 2005 Elsevier GmbH.
Karunamoorthi, K., Hailu, T. (2014): Insect repellent plants traditional usage practices in the Ethiopian malaria epidemic-prone setting: an ethnobotanical survey. Journal of Ethnobiology and Ethnomedicine 10: 22.
Feyissa, FT., Shigut, MM., Hailemariam, Tilahun, BT., Regassa, T., Kergano, NK. (2017): Ethnobotanical study of ethnoveterinary plants in Kelem Wollega Zone, Oromia Region, Ethiopia, 16: 307-317.
Teklehaymanot, T., Giday, M., Medhin,. G, Mekonnen, Y. (2006): Knowledge and use of medicinal plants by people around Debre Libanos monastery in Ethiopia. Journal of Ethnopharmacology doi: 10.1016/j.jep.2006.11.019.
Giday, M., Teklehaymanot, T., Animut, A., Mekonnen, Y. (2007): Medicinal plants of the Shinasha, Agew-awi and Amhara people sin northwest Ethiopia. J. Ethnopharmacol, 110: 516-525.
Birhan, YS., Kitaw, SL., Alemayehu, YA., Mengesha, NM. (2018): Ethnobotanical study of medicinal plants used to treat human diseases in Enarj Enawga District, East Gojjam Zone, Amhara Region, Ethiopia. SM J Med Plant Stud 1: 1006.
Maryo, M. (2013): Enset-Based Agrobiodiversity in the Agricultural Landscape of Kambatta Tembaro, Southern Ethiopia. A Thesis Submitted to the Department of Plant Biology and Biodiversity management Presented in Fulfillment of the Requirements for the Degree of Doctor of Philosophy (Biology: BotanicalScience). Addis Ababa University, Ethiopia.
Mekuanent, T., Zebene, Z., Solomon, Z. (2016): Ethnobotanical Study of Medicinal Plants in Chilga District, Northwestern Ethiopia. Journal of Natural RemediesDOI: 10.18311/jnr/2015/476.
Teklehaymanot, T., Giday, M. (2007): Ethnobotanical study of medicinal plants used by people in ZegiePeninsula, Northwestern Ethiopia. Journal of Ethnobiology and Ethnomedicine, 3: 12.
Mesfin, F., Seta, T., Assefa, A. (2014): An Ethnobotanical Study of Medicinal Plants in Amaro Woreda, Ethiopia. Ethnobotany Research & Applications 12: 341-354.
Teklay, A., Abera, B., Giday, M. (2013): An ethnobotanical study of medicinal plants used in Kilte Awulaelo District, Tigray Region of Ethiopia. Journal of Ethnobiology and Ethnomedicine 9: 65.
Kloos, H., Menberu, T., Tadele, A., Chanie, T., Debebe, Y., Abebe, A., Zealiyas, K., Tadele, G, Mohammed, M., Debella, A. (2014): Traditional medicines sold by vendors in Merkato, Addis Ababa: Aspects of their utilization, trade, and changes between 1973 and 2014. Ethiop. J. Health Dev, 28: 2.
Demie, G., Negash, M., Awas, T. (2018): Ethnobotanical study of medicinal plants used by indigenous people in andaround Dirre Sheikh Hussein heritage site of South-eastern Ethiopia. Journal of Ethnopharmacology, 220: 87–93.
Belayneh, A., Asfaw, Z., Demissew, S., Bussa, NF. (2012): Medicinal plants potential and use by pastoral and agro-pastoral communities in Erer valley of Babile Wereda, eastern Ethiopia. J Ethnobiol Ethnomed 1: 42.
Misha, G., Yarlagadda, R., Wolde-Mariam, M. (2014): Knowledge, attitude, practice and management of traditional medicine among people of Shopa Bultum, southeast Ethiopia. Res J Pharm Biol Chem Sci, 5: 152-170.
Tirfessa, K., Belude, T., Denu. (2017):Ethnobotanical study of medicinal plants in Akakidistrict, East Shewa Zone, Oromia regional state, Ethiopia. Journal of Medicinal Plants Studies, 2: 353-360.
Zonyane, S., Van Vuuren, SF., Makunga, NP. (2012): Pharmacological and phytochemical analysis of a medicinal plant mixture that is used as traditional medicine in Western Cape. Paper presented at South Africa Association of Botanist 38th Annual Conference, 15–18 January 2012. University of Pretoria, Pretoria; 124.
Bussman R W, Sharon D. (2006): Traditional medicinal plant use in Northern Peru: tracking two thousand years of healing culture. Journal of Ethnobiology and Ethnomedicine, 2: 47, doi: 10.1186/1746-4269-2-47.
Flatie, T., Gedif, T., Asres, K., Gebre-Mariam, T. (2009): Ethnomedical survey of Berta ethnic group Assosa Zone, Benishangul-Gumuz regional state, mid-west Ethiopia. Journal of Ethnobiology and Ethnomedicine, 5: 14, doi: 10.1186/1746- 4269-5-14.
Tolossa, K., Debela, E., Athanasiadou, S., Tolera, A., Ganga, G., Houdijk, JGM. (2013): Ethno-medicinal study of plants used for treatment of human and livestock ailments by traditional healers in South Omo, Southern Ethiopia. Journal of Ethnobiology and Ethnomedicine 9: 32.
Van Andel, T., Mitchell, S., Volpato, G., Vandebroek, I., Swier, J., Ruysschaer, S., Jiménez, CAR., Raes, N. (2012): In search of the perfect aphrodisiac: Parallel use of bitter tonics in West Africa and the Caribbean. J Ethnopharmacol 143: 840–850.
Voeks, RA. (2009): Traditions in Transition: African diaspora ethnobotany in Low land South America. In Mobility and migration in indigenous Amazonia: contemporary ethnoecological perspectives. Edited by Alexiades M. London: Beghahn Books; 275–294.
Ragunathan, M., Abay, SM. (2009): Ethnomedicinal survey of folk drugs used in Bahirdar Zuria District, Northwestern Ethiopia. Indian J Traditional Knowledge 2009, 8: 281–284.
Aschale, Y., Wubetu, M., Reta, H. (2018): Ethnobotany of Medicinal Plants Used to Treat Leishmaniasis in Ethiopia: A Systematic Review. Tradit Med Clin Natur, 7: 2
Manahlie, B., Feyissa, T. (2014): Micropropagation of Kebericho: AnEndandered Ethiopian Medicinal Plant. American Journal of Plant Sciences, 5: 3836-3847.
Bizuayehu, B., Assefa, T. (2017): Ethnobotanical value of medicinal plant diversity in Cheha district, Guraghe zone, Southern Nations, Nationalities and Peoples (SNNPR) of Ethiopia. J. Med. Plants Res, 28: 445-454.
Ameya, G., Gure, A., Dessalegn, E. (2016): Antimicrobial activity of Echinops kebericho against human pathogenic bacteria and fungi. Afr J Tradit Complement Altern Med, 6: 199–203.
World Health Organization: “World malaria report”. WHO Press, Geneva, Switzerland; 2014.
Mesfin, A., Giday, M., Animut, A., Teklehaymanot, T. (2012): Ethnobotanical study of antimalarial plants in Shinile District, Somali Region, Ethiopia, and in vivo evaluation of selected ones against Plasmodium berghei. Journal of Ethnopharmacology 1: 221-7.
Toma, A., Deyno, S., Eyado, A., Fikru, A. (2017): In Vivo Antimalarial Activity of Solvent Fractions of Echinops kebericho Rootsagainst Plasmodium berghei Infected Mice. EC Microbiology 12.5: 204-212.
Biruksew, A., Zeynudin, A., Alemu, Y., Golassa, L., Yohannes, M., Debella, A., Urge, G., Spiegeleer, B D., Suleman, S. (2018): Zingiber Officinale Roscoe and Echinops Kebericho Mesfin Showed Antiplasmodial Activities against Plasmodium Berghei in a Dose dependent Manner in Ethiopia. Ethiopian journal of health sciences, 28: 5.
Jansen, O., Tits, M., Angenot, L., Nicolas, J-P., DeMol, P., Nikiema, J-B. (2012): Anti-plasmodial activity of Dicoma tomentosa (Asteraceae)and identification of urospermal A-15-Oacetateas the main active compound. Malar J 11: 289.
Adeyemi, OO., Akindele, AJ. (2008): Antidiarrheal activity of the ethyl acetate extract of Baphia nitida. J. Ethnopharmacol, 116: 407–412.
Prashant, BS. (2012): Significance of Black pepper in Ayurvedic antidiarrhoeal formulation. J. Chem Pharm Res, 4: 2162-2166. pros Dev. 5: 1 DOI: 10.4172/2376-0214.1000170.
Shiferie, F., Shibeshi, W. (2013): In vivo antidiarrheal and ex-vivo spasmolytic activities of the aqueous extract of the roots of Echinops kebericho Mesfin (Asteraceae) in rodents and isolated guinea-pig ileum. Int. J. Pharm. Pharmacol, 7: 110-116.
Hu, J., Gao, W., Ling, N., Liu, C. (2009): Antidiarrheal and intestinal modulatory activities of Wei-Chang-An-Wan extract. J. Ethnopharmacol 125: 450–455.
Meite, S., Nguessan, DJ., Bahi, C., Yapi, HF., Djaman, AJ., Guina, FG. (2009): Antidiarrheal activity of the ethyl acetate extract of Morinda morindoides in rats. Trop. J. Pharm. Res, 3: 201-207.
Kloss, H. (1977): Ethnomedicine, 4: 63–104.
Grimaldi, G., Tesh, R. (1993): Leishmaniasis of the New World: current concepts and implications for future research. Clin Microbiol Rev, 6: 230-250.
Ready, PD. (2013): Biology of phlebotomine sand flies as vectors of disease agents. Annu Rev Entomol 58: 227-250.
Birhane, E., Aynekulu, E., Mekuria, W., Endale, D. (2011): Management, use and ecology of medicinal plants in the degraded dry lands of Tigray, Northern Ethiopia. J. Horticul. For 2: 32-41.
Mesfin, K., Tecle, G., Tesfay, T. (2013): Assessment of threatening factors of medicinal plant species in Samre district, South-eastern Tigray, northern Ethiopia. J. Med. Plant Stud, 4: 38–43.
Khan, SM., Page, S., Ahmad, H., Harper, DM. (2012): Anthropogenic influences on the natural ecosystem of the Naran Valley in the Western Himalayas Pakistan. Pak. J. Bot, 2: 231–238.
Erenso, F., Maryo, M. (2014). Endemic plant species composition and their status in Boda Dry Evergreen Montane Forest, West Showa, Ethiopia. Int. J. Biodivers. Conserv, 7: 563-569.
Maryo, M., Nemomissa, S., Bekele, T. (2015): An ethnobotanical study of medicinal plants of the Kembatta ethnic group in Enset-based agricultural landscape of Kembatta Tembaro (KT) Zone, Southern Ethiopia. Asian Journal of Plant Science and Research, 5 (7): 42-61.
Kloos, H. (1976): Preliminary studies of medicinal plants and plant products in Ethiopian markets. J. Ethiop. Pharm. Assoc, 4: 63-102.
Dalle, G., Maass, BL., Isselstein, J. (2005): Plant Biodiversity and Ethnobotany of Borana Pastoralists in Southern Oromia, Ethiopia. Economic Botany, 1: 43-65.
Turek, I., Carvahlo, MSR., Wube, A., Bucar, F. (2016): Headspace analysis of the smoke of Echinops kebericho Mesfin. Conference Paper.
Global Environment Facility: Capacity Building for Access and Benefit Sharing and Conservation and Sustainable Use of Medicinal Plants. Ethiopia ABS CSUMP CEO Endorsement Document;
Balcha, A., Legesse, N., Jochen, K. (2009): In Vitro and ex Vitro Seed-Based Propagation Methods of Echinops kebericho Mesfin: A Threatened Medicinal Plant. Journal of Applied Horticulture, 10: 164-168.
Science Publishing Group
1 Rockefeller Plaza,
10th and 11th Floors,
New York, NY 10020
Tel: (001)347-983-5186