Fatty Alcohols Isolated from Prosopis africana and Evaluation of Antibacterial and Antituberculosis Activities
Journal of Diseases and Medicinal Plants
Volume 4, Issue 5, October 2018, Pages: 128-132
Received: Oct. 6, 2018; Accepted: Nov. 5, 2018; Published: Dec. 3, 2018
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Nganso Ditchou Yves Oscar, Department of Chemistry, Faculty of Science, University of Maroua, Maroua, Cameroon
Soh Desire, Department of Organic Chemistry, Higher Teachers Training College, University of Bamenda, Bamenda, Cameroon
Ndogo Eteme Olivier, Department of Organic Chemistry, Faculty of Science, University of Yaounde I, Yaounde, Cameroon
Mala Opono M. T. G., Department of Biochemistry, Faculty of Science, University of Yaounde I, Yaounde, Cameroon
Nyasse Barthelemy, Department of Organic Chemistry, Faculty of Science, University of Yaounde I, Yaounde, Cameroon
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Prosopis africana, Family Leguminoceae, is used in ethnomedicine to treat different ailments including, diarrhoea, bacillary dysentery, malaria, male sterility and as a cardiotonic. This research aims at evaluating the antibacterial and antituberculosis activities of fatty alcohol. Heneicosanol (1), hexacosanol (2), nonacosanol (3), β-sitosterol (4), quercetin (5), β-sitosterol 3-O-β-D-glucopyranoside (6) and quercitrin (7) were isolated from the leaves of Prosopis africana. Their structures were elucidated on the basis of a spectroscopic analysis and a comparison of their data spectral with those reported in the literature. Heneicosanol (1), hexacosanol (2), nonacosanol (3) were isolated for the first time to this plant and was subject of antibacterial and antituberculosis activities. The results of this study suggest that the compounds 1, 2, 3 had an MBC a respective value of 1.56 µg/mL, 1.62 µg/mL, 0.12 µg/mL against M. smegmatis, M. tuberculosis. The study of fatty alcohols provides evidence of activity against clinical isolate of mycobacteria, significant anti-inflammatory and analgesic properties, and provides a basis for its possible use as an affordable and effective Antituberculosis agent from natural product.
Prosopis africana, Fatty Alcohols, Antibacterial Activities, Antituberculosis Activities
To cite this article
Nganso Ditchou Yves Oscar, Soh Desire, Ndogo Eteme Olivier, Mala Opono M. T. G., Nyasse Barthelemy, Fatty Alcohols Isolated from Prosopis africana and Evaluation of Antibacterial and Antituberculosis Activities, Journal of Diseases and Medicinal Plants. Vol. 4, No. 5, 2018, pp. 128-132. doi: 10.11648/j.jdmp.20180405.12
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