Journal of Diseases and Medicinal Plants
Volume 4, Issue 5, October 2018, Pages: 120-127
Received: Oct. 11, 2018;
Accepted: Oct. 29, 2018;
Published: Nov. 21, 2018
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Nganso Ditchou Yves Oscar, Department of Chemistry, Faculty of Science, University of Maroua, Maroua, Cameroon
Tatsimo Ndendoung Simplice Joel, Department of Chemistry, Higher Teachers’ Training College, University of Maroua, Maroua, Cameroon
Amang A. Ngoung Gabrielle Ange, Department of Chemistry, Faculty of Science, University of Maroua, Maroua, Cameroon
Soh Desire, Department of Organic Chemistry, Higher Teachers’ Training College, University of Bamenda, Bamenda, Cameroon
Simo Nemg Fredy Brice, Department of Biochemistry, Faculty of Science, University of Yaounde I, Yaounde, Cameroon
Nyasse Barthelemy, Department of Organic Chemistry, Faculty of Science, University of Yaounde I, Yaounde, Cameroon
The purpose of this study was to evaluate the antioxidant activity of compounds isolated from Clerodendrum splendens leaves. The leaves of Clerodendrum splendens are used in traditional medicine by indegenous people to treat shingles, spleen in children, asthma, rheumatism, ulcers and malaria. In vivo and in vitro studies carried out by many researchers have shown that Clerodendrum splendens has antioxidant properties. The chemical study of the methanol extract of Clerodendrum splendens leaves (Lamiaceae) led to the isolation of three compounds: Triancontanol (1), (22E, 24S) - Stigmasta - 5, 22, 25 - trien – 3β-ol(2); 3-O-D-glucopyranoside of (22E, 24S) - Stigmasta - 5,22,25 - trien - 3β-ol (3). Their structures were elucidated on the basis of a spectroscopic analysis and a comparison of their data spectral with those reported in the literature. The results of the antioxidant activity have shown that the compounds 1 and 2 inhibit the peroxidation of the hepatic lipids, they also show that the compounds 1, 2 and 3 have a reducing effect on Fe2+. However, the compounds 1, 2 and 3 have an OH reduction power which is directly proportional to the concentration of these compounds compared to that of vitamin C, which made it possible to determine the IC50 of the different compounds. Furthermore, the compounds 1 and 2 have higher IC50 than that of vitamin C (5.613 ± 0.117). The results of this study suggest that Clerodendrum splendens represents an untapped source of compounds with potential antioxidant activity that could be explored in the development of new therapeutic natural products.
Nganso Ditchou Yves Oscar,
Tatsimo Ndendoung Simplice Joel,
Amang A. Ngoung Gabrielle Ange,
Simo Nemg Fredy Brice,
Chemical Constituents of Clerodendrum splendens (Lamiaceae) and Their Antioxidant Activities, Journal of Diseases and Medicinal Plants.
Vol. 4, No. 5,
2018, pp. 120-127.
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