The Effect of ethanol Psidium Guava leaf extract on KCl Induced Contracted Aortic tissues of Guinea Pigs
Journal of Diseases and Medicinal Plants
Volume 3, Issue 1, February 2017, Pages: 7-11
Received: Jan. 2, 2017; Accepted: Jan. 17, 2017; Published: Feb. 16, 2017
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Authors
Abayneh Elias, Department of Biological Sciences, Dire Dawa University, Dire Dawa, Ethiopia
Daniel Seifu, Department of Medical Biochemistry, School of Medicine, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia
Frank Ashall, Department of Medical Biochemistry, School of Medicine, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia
Tesfaye Tolessa, Department of Medical Physiology, School of Medicine, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia
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Abstract
Hypertension is elevation of systolic blood pressure greater than or equal to 140 mm Hg and/or diastolic blood pressure greater than or equal to 90 mm Hg. It affects 1 billion people and accounts for approximately 7.1 million deaths annually. It is significant risk factor for cardiovascular disorders. Some medicinal plants are traditionally used to treat hypertension. Psidium guava is one of widely cultivated medicinal plant used as traditional medication for diabetes, vomiting, diarrhea and dyslipidemia. The study was designed to identify effect of P. guava leaf extract on hypertension in guinea pigs. The study was conducted on six male guinea pigs to measure the effect of ethanol P. guava leaf extract by using invasive method. The result was analyzed by using paired t-test, independent student t test, one –way ANOVA. Ethanol extract of P. guava leaf showed a significant (p= 0.001) ability to relax isolated aortic tissue of guinea pigs in dose dependent manner, after induction of aortic muscle contraction by high potassium chloride concentrations (80 mM KCl). The effects of P. guava leaf extract in relaxation contracted aortic tissue was may be due to numerous effect of phytochemicals.
Keywords
Aortic Tissue, Blood Pressure, Cardiovascular Diseases, Effect, Extract, Guinea Pigs, Hypertension, P. Guava
To cite this article
Abayneh Elias, Daniel Seifu, Frank Ashall, Tesfaye Tolessa, The Effect of ethanol Psidium Guava leaf extract on KCl Induced Contracted Aortic tissues of Guinea Pigs, Journal of Diseases and Medicinal Plants. Vol. 3, No. 1, 2017, pp. 7-11. doi: 10.11648/j.jdmp.20170301.12
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Copyright © 2017 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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