Mechanical, Mucoadhesive and Biocompatibility Behavior of Hydrogel Films: A Slow Anticancer Drug Delivery System
American Journal of Polymer Science and Technology
Volume 1, Issue 1, September 2015, Pages: 1-8
Received: Jul. 28, 2015; Accepted: Sep. 1, 2015; Published: Sep. 2, 2015
Views 6467      Downloads 229
Baljit Singh, Department of Chemistry, Himachal Pradesh University Shimla, Himachal Pradesh, India
Arindam Sharma, Resident, Department of Medicine, Indira Gandhi Medical College Shimla, Himachal Pradesh, India
A. Dhiman, Department of Chemistry, Himachal Pradesh University Shimla, Himachal Pradesh, India
S. Kumar, Department of Chemistry, Himachal Pradesh University Shimla, Himachal Pradesh, India
Article Tools
Follow on us
Systemic administration of anticancer drugs is associated with a number of side effects. Therefore, it needs some targeted drug delivery system to deliver the drug which would ensure relief from side effects along with the direct delivery of drug to the site of action in a controlled manner. Keeping in view the importance of mucoadhesive polymers in site specific drug delivery, in the present work, an attempt has been made to prepare, polysaccharide gum, PVA and AAm based mucoadhesive polymeric films for use as slow, site specific drug delivery system for oral cancer drug 5-flurouracil. Characterizations of polymers have been carried out by SEMs, EDAX, FTIR, TGA/DTA/DTG, XRD and swelling studies. The in vitro release dynamics of drug and some important biomedical properties of hydrogel films (like blood compatibility, mucoadhesion, tensile strength, relaxation, resilience and bursting strength) have also been studied. The values of maximum detachment force (Fmax) and work of adhesion (Wad) of) polymeric films have been observed (1.026±0.175 N) and (0.073±0.010 N mm) respectively. The release of drug in simulated saliva fluid occurred through Fickian diffusion mechanism and polymer films have been observed to be biocompatible nature.
Polymers Matrix, Mucoadhesive, Hydrogels, Drug Delivery, Anticancer, Biocompatibility
To cite this article
Baljit Singh, Arindam Sharma, A. Dhiman, S. Kumar, Mechanical, Mucoadhesive and Biocompatibility Behavior of Hydrogel Films: A Slow Anticancer Drug Delivery System, American Journal of Polymer Science and Technology. Vol. 1, No. 1, 2015, pp. 1-8. doi: 10.11648/j.ajpst.20150101.11
N.V.S. Madhav, A.K. Shakya, P. Shakya, K. Singh, Orotransmucosal drug delivery systems: A review. J. Control. Release. 140 (2009) 2-11.
N. Salamat-Miller, M. Chittchang, T.P. Johnston, The use of mucoadhesive polymers in buccal drug delivery, Adv. Drug Delivery Rev. 57 (2005) 1666-1691.
T. Nagai, Y. Machida, Buccal delivery systems using hydrogels, Adv. Drug Delivery Rev. 11 (1993) 179-191.
S. Singh, S. Jain, M. Muthu, S. Tiwari, R. Tilak, Preparation and evaluation of buccal bioadhesive films containing clotrimazole, AAPS Pharma. Sci. Tech. 9 (2008) 660–667.
M. Hamidi, A. Azadi, P. Rafiei, Hydrogel nanoparticles in drug delivery, Adv. Drug Delivery Rev. 60 (2008) 1638-1649.
N. Bhattarai, J. Gunn, M. Zhang. Chitosan-based hydrogels for controlled, localized drug delivery, Adv. Drug Delivery Rev. 62 (2010) 83-99.
K. Knuth, M. Amiji, J.R. Robinson, Hydrogel delivery systems for vaginal and oral applications: Formulation and biological considerations, Adv. Drug Delivery Rev. 11 (1993), 137-167.
L. Achar, N.A. Peppas, Preparation, characterization and mucoadhesive interactions of poly(methacrylic acid) copolymers with rat mucosa, J. Control. Release. 31 (1994) 271-276.
Y.B. Huang, W. Leobandung, A. Foss, N.A. Peppas, Molecular aspects of muco- and bioadhesion: tethered structures and site-specific surfaces, J. Control. Release. 65 (2000) 63-71.
T. Goto, M. Morishita, N.J. Kavimandan, K. Takayama, N.A. Peppas, Gastrointestinal transit and muco-adhesive characteristics of complexation hydrogels in rats, J. Pharma. Sci. 95 (2006) 462-469.
J.E. Codd, P.B. Deasy, Synergistic antifungal interaction between miconazole nitrate and chlorhexidine acetate, Int. J. Pharma. 173 (1998) 3–11.
K.G. Desai, T.M. Kumar, Preparation and evaluation of a novel buccal adhesive system, AAPS Pharma. Sci. Tech. 5 (2004) 1-9.
J.M. Llabot, R.H. Manzo, D.A. Allemandi, Double-layered mucoadhesive tablets containing nystatin, AAPS Pharma. Sci. Tech. 3 (2002) E22.
R.L. McQuinn, D.C. Kvam, M.J. Maser, A.L. Miller, S. Oliver, Sustained oral mucosal delivery in human volunteers of buprenorphine from a thin non-eroding mucoadhesive polymeric disk, J. Control. Release. 34 (1995) 243-250.
W. Weiping, Tragacanth and karaya. In: Handbook of hydrocolloids, G.O. Philips, P.A. Williams, (Eds.), Cambridge: Woodhead, (Chapter 13), 2000, pp. 231-245.
O. Ben-Zion, A. Nussinovitch, Physical properties of hydrocolloid wet glues, Food Hydrocol. 11 (1997) 429-442.
S. Roy, K. Pal, A. Anis, K. Pramanik, B. Prabhakar, Polymers in mucoadhesive drug delivery system: a brief note, Des. Monomers Polym. 12 (2009) 483-495.
G. Bello, I.T. Jackson, M. Keskin, C. Kelly, K. Dajani, R. Studinger, E.M. Kim, D. Lincoln, B. Silberberg, A. Lee, The use of polyacrylamide gel in soft-tissue augmentation: an experimental assessment, Plast. Reconstr. Surg.. 119 (2007) 1326-1336.
J. L. Grem,. 5-Fluorouracil: forty-plus and still ticking. A review of its preclinical and clinical development. Invest New Drugs 2000, 18, 299-313
B. Singh, L. Pal, Sterculia crosslinked PVA and PVA-poly(AAm) hydrogel wound dressings for slow drug delivery: Mechanical, mucoadhesive, biocompatible and permeability properties, J. Mech. Behav. Biomed. Mater. 9 (2012) 9-21.
P.L. Ritger, N.A. Peppas, A simple equation for description of solute release I. Fickian and non-Fickian release from non-swellable devices in the form of slabs, spheres, cylinders or discs, J. Control. Release. 5 (1987) 23–36.
P.L. Ritger, N.A. Peppas, A simple equation for description of solute release I. Fickian and non-Fickian release from swellable devices, J. Control. Release. 5 (1987) 23–36.
International standard organization (ISO 10993-4): Biological Evaluation of Medical Device – Part 4 – Selection of Tests For interaction with Blood, Geneva. 1999.
Y. Imai, Y. Nose, New method for evaluation of antithrombogenicity of materials, J. Biomed. Mater. Res. 6 (1972), 165-172.
American Society for Testing and Materials, 2000. ASTM F 756-00: Standard Practices for Assessment of Haemolytic Properties of Materials, Philadelphia.
N. Thirawong, J. Nunthanid, S. Puttipipatkhachorn, P. Sriamornsak, Mucoadhesive properties of various pectins on gastrointestinal mucosa: An in vitro evaluation using texture analyzer, Eur. J. Pharma. Biopharma. 67 (2007), 132-140.
K. Peh, C. Wong, Polymeric films as vehicle for buccal delivery: swelling, mechanical, and bioadhesive properties, J. Pharma Pharma. Sci. 2 (1999) 53-61.
P.B. Sutar, R.K. Mishra, K. Pal, A.K. Banthia, Development of pH sensitive polyacrylamide grafted pectin hydrogel for controlled drug delivery system, J. Mater. Sci.: Mater. Med. 19 (2008) 2247-2253.
B.R. Nayak, D.R. Biswal, N.C. Karmakar, R.P. Singh, Grafted hydroxypropyl guargum: Development, characterization and application as flocculating agent, Bull. Mater. Sci. 25 (2002) 537-540.
E.S. Costa-Júnior, E.F. Barbosa-Stancioli, A.A.P. Mansur, W.L. Vasconcelos, H.S. Mansur, Preparation and characterization of chitosan/poly(vinyl alcohol) chemically crosslinked blends for biomedical applications, Carbohydr. Polym. 76 (2009) 472–481.
A. Mishra, J.H. Clark, S. Pal, Modification of Okra mucilage with acrylamide: Synthesis, characterization and swelling behavior, Carbohydr. Polym. 72 (2008) 608–615.
L. Xinming, C. Yingde, Study on synthesis and chloramphenicol release of poly(2-hydroxyethylmethacrylate-co-acrylamide) hydrogels. Chin. J. Chem. Eng. 16 (2008) 640-645.
J.N. Hiremath, B. Vishalakshi, Effect of crosslinking on swelling behaviour of IPN hydrogels of guar gum & polyacrylamide, Der Pharma Chemica. 4 (2012) 946-955.
A.K. Bajpai, A. Giri, Water sorption behaviour of highly swelling (carboxy methylcellulose-g-polyacrylamide) hydrogels and release of potassium nitrate as agrochemical, Carbohydr. Polym. 53 (2003) 271–279.
C.F. Wong, K.H. Yuen, K.K. Peh, An in-vitro method for buccal adhesion studies: importance of instrument variables. Int. J.Pharma. 180 (1999) 47–57.
N. Hassan, R.K. Khar, M. Ali, J. Ali, Development and evaluation of buccal bioadhesive tablet of an anti-emetic agent ondansetron. AAPS Pharm. Sci. Tech. 10 (2009) 1085-1092.
M.J. Tobyn, J.R. Johnson, P.W. Dettmar, Factor affecting in vitro gastric mucosa adhesion I. Test conditions and instrumental parameters. Eur. J. Pharma. Biopharma. 41 (1995) 235–241.
M.J. Tobyn, J.R. Johnson, P.W. Dettmar, Factor affecting in vitro gastric mucosa adhesion II. Physical properties of polymers, Eur. J. Pharma. Biopharma. 42 (1996) 56-61.
C. Eouani, P. Piccerelle, P. Prinderre, E. Bourret, J. Joachim, In-vitro comparative study of buccal mucoadhesive performance of different polymeric films, Eur. J. Pharma. Biopharma. 52 (2001), 45-55.
N. Zhang, Y. Yin, S.J. Xu, W.S. Chen, 5-fluorouracil: mechanisms of resistance and reversal strategies, Molecules. 13 (2008) 1551-1569.
J.L. Arias, M.A. Ruiz, M. López-Viota, A.V. Delgado, Poly(alkylcyanoacrylate) colloidal particles as vehicles for antitumour drug delivery: A comparative study, Colloids Surf. B: Biointerfaces. 62 (2008) 64-70.
A.D. Woolfson, D.F. McCafferty, P.A. McCarron, J.H. Price, A bioadhesive patch cervical drug delivery system for the administration of 5-fluorouracil to cervical tissue. J. Control. Release. 35 (1995) 49-58.
Science Publishing Group
1 Rockefeller Plaza,
10th and 11th Floors,
New York, NY 10020
Tel: (001)347-983-5186