Effect of Achyranthes Aspera Leaf Extract on Hematological Parameters of Swiss Albino Mice
World Journal of Public Health
Volume 4, Issue 4, December 2019, Pages: 96-101
Received: May 9, 2018; Accepted: May 24, 2018; Published: Dec. 10, 2019
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Emmanuel Asuquo Etim, Department of Laboratory Services, Federal Medical Centre, Yola, Adamawa State, Nigeria
Yusuf Abdulhakeem Adebayo, Department of Laboratory Services, Federal Medical Centre, Yola, Adamawa State, Nigeria
Obeagu Emmanuel Ifeanyi, Department of University Health Services, Micheal Okpara University, Abia State, Nigeria
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Background/Objective: Achyranthes aspera is an erect flowering medicinal herb use in folkloric medicine. This study aims to examine the effect of methanolic leaf extract of Achyranthes aspera on hematological parameters of Swiss albino mice. Materials and Methods: 70 adult mice of both sexes with mean weight of 22 ± 5g were used for this study. Achyranthes aspera leaves was pulverized to coarse powder from where methanolic extract was obtained. 0.2ml of 50mg/kg, 100mg/kg, and 200mg/kg respectively of leaf extract was administered to mice for four days. After administration, 1ml of blood was collected from mice through cardiac puncture into EDTA bottle for full blood count estimation using Abacus-80 hematological analyzer. Results: The administration of 50mg/kg, 100mg/kg and 200mg/kg doses of the extract resulted in increased lymphocyte count from 29.4±7.35% to 70.4±0.25%, 70.5±0.219% and 81.3±0.282% respectively at P>0.05 while neutrophil value was reduced from 55.2±11.05 x 109/l to 14.0±0.216x 109/l, 11.2±0.109x109/l and 12.3±0.148 x109/l. The administration of 50mg/kg, 100mg/kg and 200mg/kg doses of the extract increases platelet count from 99.0±0.52x103/ul to 529±0.01x 103/ul, 332±0.523x103/ul and 135±0.543x103/ul respectively. Conclusion: Ingestion of methanolic leaf extract of Achyranthes aspera resulted in a dose dependent changes in hematological parameter of albino mice including significant increase in lymphocyte and platelet counts. This plant’s leaf extract may therefore have the potentials of being effective in the treatment of diseases cause by thrombocytopenia and lymphocytopenia in mammals. It is believed that information provided in this study can enhance appropriate usage of Achyranthes aspera in folkloric medicine in Nigeria.
Achyranthes Aspera, Hematological Parameter, Albino Mice
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Emmanuel Asuquo Etim, Yusuf Abdulhakeem Adebayo, Obeagu Emmanuel Ifeanyi, Effect of Achyranthes Aspera Leaf Extract on Hematological Parameters of Swiss Albino Mice, World Journal of Public Health. Vol. 4, No. 4, 2019, pp. 96-101. doi: 10.11648/j.wjph.20190404.14
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