Premarital Sickle Cell Genetic Screening Knowledge, Attitude and Practice Compared Among Married and Unmarried Youths in Nigeria
World Journal of Public Health
Volume 3, Issue 3, September 2018, Pages: 76-82
Received: Jun. 17, 2018; Accepted: Jul. 9, 2018; Published: Aug. 9, 2018
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Tajudeen Olusegun Rasheed, Medical Department, Economic and Financial Crimes Commission, Ikoyi, Nigeria
Wasiu Adebowale Afolabi, School of Post Basic Psychiatric/Mental Health Nursing, Federal Neuropsychiatric Hospital, Yaba, Nigeria
Rukayat Ololade Abdul Rasheed, Tarukah Resources Consult, Agege, Nigeria
Rasheedat Adenike Ajala, Department of Nursing, National Open University, Victoria Island, Nigeria
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Premarital sickle cell genetic screening is a test that determines the genotype of the intending couple before marriage. As a result, counseling is given before and after the test. This study assessed and compared the level of knowledge, attitude and practices of premarital sickle cell screening among married and unmarried youths in Epe, Nigeria. A cross-sectional descriptive research design was used to examine 370 participants, using stratified sampling technique. Data were collected with an instrument and analyzed, stating the mean, frequency and standard deviation. Scores were built for knowledge, attitude and practice. Chi-square test with p < 0.05 was used to test the hypotheses. The study revealed that an association exists between knowledge and practice of premarital sickle cell genetic screening among unmarried (X2 = 6.359, Cramer’s v=0.09, p=0.0116, df = 1) and married (X2 = 12.9325, Cramer’s v=0.10, p=0.0003, df =1) youths. Similarly, an association exists between attitude and practices of premarital sickle cell genetic screening for unmarried youth (X2 = 20.3077, p=0.0007, Cramer’s v=0.17, df = 1) but for married youths there was no association (X2 = 0.0168, p = 0.8969, Cramer’s v=0.08, df = 1). Furthermore, finding revealed that 77% of the married participants did not have sickle cell genetic screening test before marriage, while 67% of the unmarried participants were not willing to carry out the test, due to fear of the unknown and stigma. Conclusively, the level of knowledge of the participants’ was good (70.06%), attitude was negative towards practices of premarital sickle cell genetic screening. Therefore, continuous health education that focuses on sickle cell genetic screening test could improve the practices among the youth to avert the associated morbidity and mortality.
Premarital, Genetic Screening, Sickle Cell Disease, Youth, Nigeria
To cite this article
Tajudeen Olusegun Rasheed, Wasiu Adebowale Afolabi, Rukayat Ololade Abdul Rasheed, Rasheedat Adenike Ajala, Premarital Sickle Cell Genetic Screening Knowledge, Attitude and Practice Compared Among Married and Unmarried Youths in Nigeria, World Journal of Public Health. Vol. 3, No. 3, 2018, pp. 76-82. doi: 10.11648/j.wjph.20180303.12
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WHO. Sickle-cell disease and other hemoglobin disorders. 2016; 1-3. Retrieved from
Genetic Learning Center. Genetic disorders. 2016; 1-7. Retrieved from
Saraf SL, Molokie RE, Nouraie M, Sable CA, Luchtman-Jones L. Differences in the clinical and genotypic presentation of sickle cell disease around the world. Pediatrics Respiratory Reviews. 2014; 15(1): 4-12.
Nnaji GA, Ezeagwuna DA, NnajiI JF, Osakwe JO, Nwigwe AC. Prevalence and pattern of sickle cell disease in premarital couples in Southeastern Nigeria. Nigerian J of Clinical Practice. 2013; 16(3): 309-314.
Chakravorty S, Williams TN. Sickle cell disease: a neglected chronic disease of increasing global health importance. Archives of Disease in Childhood. 2015; 100(1): 48-53.
Oyedele EA, Emmanuel A, Gaji LD, Ahure DOE. Awareness and acceptance of premarital genotype screening among youths in a Nigerian community. Internatl J of Medical and Health Research. 2015; 1(1): 17-21. Retrieved from{adpostion}%26utm_phone=833-539-4592
Anie KA, Akinyanju OO, Egunjobi FE. Psychosocial impact of sickle cell disorder: perspectives from a Nigerian setting. 2010: University press.
Ajazen I, Fishbein M. Understanding attitudes and predicting. Social Behavior. Eagle wood cliffs. 1980; New Jersey.
Alkindi M. Salha AR, AL-kend M. Knowledge and attitude of University Students towards Premarital Sickle Cell screening Program. Coman medical journal. 2012; 27(4): 291 – 296.
Krejcie RV, Morgan DW. Determining sample size for research activities. Educational and psychological measurement. 1970; 30: 607-610.
Omuemu VO, Obarisiagbon OE, Ogboghodo EO. Awareness and acceptability of premarital screening of sickle cell disease among undergraduate students of the University of Benin, Benin City, Edo State. J of Med. and Biomedical Research. 2013; 12(1): 91-104.
Durotoye IA, Salaudeen AG, Babatunde AS, Bosah EC. Knowledge and perception of sickle cell disease among senior secondary school students in Ilorin metropolis. The Tropical J of Health Sciences. 2013; 20(2): 1-7. Retrieved from
Gbenol PK, Brisibe SF, Ordinioha B. Knowledge, attitude and uptake of premarital screening for the sickle trait among married couples in a semi urban community in South-South Nigeria. European J of Prev. Med. 2015; 3: 49-54.
Adewoyin AS. Management of sickle cell disease: a review for physician education in Nigeria (sub-saharan Africa). National Library of Medicine. Anemia. 2015; 791498.
Aneke J, Okocha C. Sickle cell disease genetic counseling and testing: A review Alternate title: Review Article. Archives of Med. and Health Sciences. 2016; 4(1): 50.
Nnodu OE. Interventions for the prevention of sickle cell disease at primary health care centres in Gwagwalada area council of the Federal Capital Territory, Nigeria. Cureus. 2014; 6(8): e194. doi:10. 7759/cureus. 194
Ogun GO, Ebili H, Kotila TR. Autopsy findings and pattern of mortality in Nigerian sickle cell disease patients. National Library of Medicine. The Pan African Medical J. 2014; 18: 30.
Grosse SD, Odame I, Atrash HK, Amendah DD, Piel FB. Sickle cell disease in Africa: A neglected cause of early childhood mortality. American J of Prev. Med. 2011; 41(6): Suppl 4, S398-S405.
Afolayan JA, Jolayemi FT. Parental Attitude to Children with Sickle Cell Disease in Selected Health Facilities in Irepodun Local Government, Kwara State, Nigeria Studies on Ethno-Medicine. 2011; (1): 33-40.
Fernandes AP, Pinheiro C, Januário JN, Cangussu CB, Macedo DL, Viana MB. Mortality of children with sickle cell disease: a population study. Jornal de Pediatria. 2010. 86(4): 279-284.
Abioye-Kuteyi EA, Oyegbade O, Bello I, Osakwe C. Sickle cell knowledge, premarital screening and marital decisions among local government workers in Ile-Ife, Nigeria. African J of Primary Health Care and Family Med. 2009; 1(1): Article 22. African Online Scientific Information Systems/AOSIS (Pty) Ltd
Moronkola OA, Fadairo RA. University students in Nigeria: knowledge, attitude toward sickle cell disease, and genetic counseling before marriage. National Library of Medicine. Internatl Quarterly J of Comm. Health Edu. 2007; 26(1): 85-93.
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