Diabetes Could Be a Warning Sign of Pancreatic Cancer: A Case Report and Literature Review
International Journal of Gastroenterology
Volume 4, Issue 1, June 2020, Pages: 7-10
Received: Dec. 13, 2019;
Accepted: Jan. 2, 2020;
Published: Jan. 16, 2020
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Nassima Dekdouk, Department of Forensic and Penitentiary Medicine, Faculty of Medicine, Benyoucef Benkhedda University, Algiers, Algeria
Radia Yala, Department of Forensic and Penitentiary Medicine, Faculty of Medicine, Benyoucef Benkhedda University, Algiers, Algeria
Sofiane Hamma, Department of Forensic and Penitentiary Medicine, Faculty of Medicine, Benyoucef Benkhedda University, Algiers, Algeria
Salim Daoud, Department of Forensic and Penitentiary Medicine, Faculty of Medicine, Benyoucef Benkhedda University, Algiers, Algeria
Charafa Bouderies, Department of Forensic and Penitentiary Medicine, Faculty of Medicine, Benyoucef Benkhedda University, Algiers, Algeria
Djamil Azzouz, Department of Forensic and Penitentiary Medicine, Faculty of Medicine, Benyoucef Benkhedda University, Algiers, Algeria
Rachid Belhadj, Department of Forensic and Penitentiary Medicine, Faculty of Medicine, Benyoucef Benkhedda University, Algiers, Algeria
Pancreatic cancer (PC) is 1 of the deadliest cancers, representing the fourth leading cause of cancer death in the world; This high mortality is due to late symptom onset and because most of the cases of pancreatic cancer are stage IV at diagnosis, and hence not a candidate for curative resection. The following report will serve to emphasize the role of new-onset diabetes in certain patients as a warning sign necessitating further investigation for pancreatic cancer. It’ s about a 46-years old man was admitted in hospital «service of forensic and penitentiary medicine » for jaundice associated with progressive asthenia, abdominal pain, and weight loss. He had been diagnosed with diabetes 4 weeks earlier by his GP. Despite lifestyle changes, he had been commenced on metformin after just 2 weeks due to poor glycaemic control. Physical examination showed a mass of the upper right quadrant on palpation. Computed tomography of the abdomen showing a solid mass of 55 mm in the head of the pancreas, hypodense in particular, with mild Wirsung and bile ducts dilatation, and the focal thrombi is found at the level of the 9 mm splenomersaraic confluent, with hepatic secondary localization images. He was subsequently diagnosed with new-onset diabetes and metastatic pancreatic cancer. The treatment with basal insulin / bolus and anticoagulant therapy was instituted and after stabilization; the patient has been oriented for bilio-pancreatic derivation, and eventual biopsy in a specialized center, but unfortunately the patient died only a few weeks after. PC occurs with increased frequency in patients with type 2 diabetes mellitus (DM2) which is considered the third modifiable risk factor for pancreatic cancer after cigarette smoking and obesity. Although numerous studies have linked both entities since 1833 the mechanism behind this association are complex and not well understood by the moment.
Diabetes Could Be a Warning Sign of Pancreatic Cancer: A Case Report and Literature Review, International Journal of Gastroenterology.
Vol. 4, No. 1,
2020, pp. 7-10.
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