Liver Involvement in Leptospirosis
International Journal of Infectious Diseases and Therapy
Volume 1, Issue 1, December 2016, Pages: 6-12
Received: Oct. 30, 2016; Accepted: Nov. 17, 2016; Published: Dec. 21, 2016
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Galya Ivanova Gancheva, Department of Infectious Diseases, Epidemiology, Parasitology and Tropical Medicine, Medical University-Pleven, Bulgaria
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Liver involvement is a common feature of leptospirosis. It is variable from mild to severe hepatic dysfunction. Objective: to analyze liver involvement and to assess its prognostic value in leptospirosis. Materials and methods: We performed analysis of 100 consecutive leptospirosis cases treated in Clinic of Infectious Diseases at University Hospital – Pleven (1976-2015)(90 male, mean age 37±18 years, lethal outcome in 13%), followed by comparative analysis of group with liver involvement (n1=71) versus group without liver involvement (n2=29). Results: Fever (100%), hepatomegaly (92%), myalgia (86%), vomiting (84%), splenomegaly (74%), oliguria (69%), jaundice (63%), hypotension (49%), abdominal pain (41%), and hemorrhagic diathesis (37%) were the characteristic manifestations. Headache, myalgia, abdominal pain, oliguria, hemorrhagic diathesis, myocarditis, acute respiratory failure and pancreatitis had had a significantly higher prevalence in the group with liver involvement. Increased levels of total bilirubin (mean 157.8±71.5 µmol/L) with prevalent direct fraction, ASAT (mean 112±18 IU/L), ALAT (mean 96±78 IU/L), hypoproteinemia and hypoalbuminemia were the main laboratory parameters that expressed hepatic dysfunction. Conclusion: The most affected liver functions are bilirubin metabolism and protein synthesis. Liver involvement in leptospirosis is important factor for severity, in combination with acute renal failure has severe course and requires early diagnosis and prompt intensive treatment.
Acute Renal Failure, Hepatic Dysfunction, Leptospirosis, Liver Involvement
To cite this article
Galya Ivanova Gancheva, Liver Involvement in Leptospirosis, International Journal of Infectious Diseases and Therapy. Vol. 1, No. 1, 2016, pp. 6-12. doi: 10.11648/j.ijidt.20160101.12
Copyright © 2016 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License ( which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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