International Journal of Diabetes and Endocrinology
Volume 3, Issue 1, March 2018, Pages: 18-22
Received: Mar. 25, 2018;
Accepted: Apr. 12, 2018;
Published: May 14, 2018
Views 890 Downloads 80
Thi Mong Diep Nguyen, Faculty of Biology-Agricultural Engineering, Quy Nhon University, Quy Nhon, Viet Nam
A large number of industrial chemical products (paints, flame retardants, pharmaceuticals, pesticides) are suspected or proved to act as endocrine disruptor compounds (EDCs). In the present survey of the literature, the main issue is to consider how to classify individual products as EDC or not. In this perspective, the different mechanisms leading to endocrine disruption are described: either by direct interaction with hormone receptors leading to its stimulation or inhibition, or by effect on endogenous hormone concentration through stimulation or inhibition of its synthesis or its degradation, or its binding to transport binding proteins. The present review takes particularly in consideration the effects of EDCs on the endocrine control of Reproduction in human and animals. Indeed, a number of EDCs can act as anti-androgens, anti-estrogens, and steroidogenic enzyme inhibitors that interfere with steroid action or production and thus can alter reproductive health.
Thi Mong Diep Nguyen,
Endocrine Disruptor Compounds (EDC) Effects on Reproduction, International Journal of Diabetes and Endocrinology.
Vol. 3, No. 1,
2018, pp. 18-22.
De Falco M, Sellitti A, Sciarrillo R, Capaldo A, Valiante S, Iachetta G, Forte M, Laforgia V (2014) Nonylphenol effects on the HPA axis of the bioindicator vertebrate, Podarcis sicula lizard. Chemosphere 104: 190-196.
Combarnous Y (2017) Endocrine Disruptor Compounds (EDCs) and agriculture: The case of pesticides. C R Biol 340: 406-409.
Golub M, Doherty J (2004) Triphenyltin as a potential human endocrine disruptor. J Toxicol Environ Health B Crit Rev 7: 281-295.
Bishop PL, Willett CE (2014) The use and acceptance of Other Scientifically Relevant Information (OSRI) in the U. S. Environmental Protection Agency (EPA) Endocrine Disruptor Screening Program. Birth Defects Res B Dev Reprod Toxicol 101: 3-22.
Willett CE, Bishop PL, Sullivan KM (2011) Application of an integrated testing strategy to the U. S. EPA endocrine disruptor screening program. Toxicol Sci 123: 15-25.
Borgert CJ, Mihaich EM, Quill TF, Marty MS, Levine SL, Becker RA (2011) Evaluation of EPA's Tier 1 Endocrine Screening Battery and recommendations for improving the interpretation of screening results. Regul Toxicol Pharmacol 59: 397-411.
Reif DM, Martin MT, Tan SW, Houck KA, Judson RS, Richard AM, Knudsen TB, Dix DJ, Kavlock RJ (2010) Endocrine profiling and prioritization of environmental chemicals using ToxCast data. Environ Health Perspect 118: 1714-1720.
Yin P, Li YW, Chen QL, Liu ZH (2017) Diethylstilbestrol, flutamide and their combination impaired the spermatogenesis of male adult zebrafish through disrupting HPG axis, meiosis and apoptosis. Aquat Toxicol 185: 129-137.
Kariyazono Y, Taura J, Hattori Y, Ishii Y, Narimatsu S, Fujimura M, Takeda T, Yamada H (2015) Effect of in utero exposure to endocrine disruptors on fetal steroidogenesis governed by the pituitary-gonad axis: a study in rats using different ways of administration. J Toxicol Sci 40: 909-916.
Sikka SC, Wang R (2008) Endocrine disruptors and estrogenic effects on male reproductive axis. Asian J Androl 10: 134-145.
Warita K, Sugawara T, Yue ZP, Tsukahara S, Mutoh K, Hasegawa Y, Kitagawa H, Mori C, Hoshi N (2006) Progression of the dose-related effects of estrogenic endocrine disruptors, an important factor in declining fertility, differs between the hypothalamo-pituitary axis and reproductive organs of male mice. J Vet Med Sci 68: 1257-1267.
Witorsch RJ (2016) Effects of elevated glucocorticoids on reproduction and development: relevance to endocrine disruptor screening. Crit Rev Toxicol 46: 420-436.
Jeng HA (2014) Exposure to endocrine disrupting chemicals and male reproductive health. Front Public Health 2: 55.
Blanco-Munoz J, Lacasana M, Lopez-Flores I, Rodriguez-Barranco M, Gonzalez-Alzaga B, Bassol S, Cebrian ME, Lopez-Carrillo L, Aguilar-Garduno C (2016) Association between organochlorine pesticide exposure and thyroid hormones in floriculture workers. Environ Res 150: 357-363.
Goldman LR, Koduru S (2000) Chemicals in the environment and developmental toxicity to children: a public health and policy perspective. Environ Health Perspect 108 Suppl 3: 443-448.
Gaudriault P, Mazaud-Guittot S, Lavoue V, Coiffec I, Lesne L, Dejucq-Rainsford N, Scholze M, Kortenkamp A, Jegou B (2017) Endocrine Disruption in Human Fetal Testis Explants by Individual and Combined Exposures to Selected Pharmaceuticals, Pesticides, and Environmental Pollutants. Environ Health Perspect 125: 087004.
de Sousa G, Nawaz A, Cravedi JP, Rahmani R (2014) A concentration addition model to assess activation of the pregnane X receptor (PXR) by pesticide mixtures found in the French diet. Toxicol Sci 141: 234-243.
Crepet A, Heraud F, Bechaux C, Gouze ME, Pierlot S, Fastier A, Leblanc J, Le Hegarat L, Takakura N, Fessard V, Tressou J, Maximilien R, de Sousa G, Nawaz A, Zucchini-Pascal N, Rahmani R, Audebert M, Graillot V, Cravedi JP (2013) The PERICLES research program: an integrated approach to characterize the combined effects of mixtures of pesticide residues to which the French population is exposed. Toxicology 313: 83-93.
Ahmed MA, Vogel CF, Matsumura F (2015) Unique biochemical and molecular biological mechanism of synergistic actions of formamidine compounds on selected pyrethroid and neonicotinoid insecticides on the fourth instar larvae of Aedes aegypti (Diptera: Culicidae). Pestic Biochem Physiol 120: 57-63.