Preventive Effect of Phloretin on Components of Glycoprotein Changes in Streptozotocin Induced Diabetic Rats
International Journal of Diabetes and Endocrinology
Volume 2, Issue 2, June 2017, Pages: 30-35
Received: Feb. 28, 2017; Accepted: Apr. 28, 2017; Published: Jul. 3, 2017
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Tamilarasan Nithiya, Department of Biochemistry, Government Arts College (Autonomous), Kumbakonam, Tamilnadu, India
Rajangam Udayakumar, Department of Biochemistry, Government Arts College (Autonomous), Kumbakonam, Tamilnadu, India
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The present study was aimed to evaluate the protective effect of phloretin on glycoprotein components in serum and tissues of streptozotocin induced diabetic rats. Diabetes was induced in male Wistar rats by a single intraperitoneal injection of STZ (60 mg/kg b.w). Phloretin (25mg and 50mg/kg b.w) was administered orally to diabetic rats for 45 days. The effect of phloretin on serum glucose, glycated hemoglobin, serum and tissue glycoprotein components were studied. Phloretin administration to diabetic rats decreased the level of glucose, glycated hemoglobin and glycoprotein components in serum. There was observed a significant decrease in the level of sialic acid and significantly elevated levels of hexose, hexosamine and fucose in liver and kidney of diabetic rats. The altered levels of serum and tissue glycoprotein components were restored to near normal in diabetic rats treated with phloretin at 50mg/kg b.w. The present findings suggest that phloretin can potentially ameliorates the hyperglycemia and changes in glycoprotein components abnormalities in streptozotocin induced diabetic rats. So, the phloretin may be used as an effective therapeutic agent for diabetes mellitus in future.
Streptozotocin, Diabetes Mellitus, Phloretin, Glycoprotein
To cite this article
Tamilarasan Nithiya, Rajangam Udayakumar, Preventive Effect of Phloretin on Components of Glycoprotein Changes in Streptozotocin Induced Diabetic Rats, International Journal of Diabetes and Endocrinology. Vol. 2, No. 2, 2017, pp. 30-35. doi: 10.11648/j.ijde.20170202.13
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