Genetic Polymorphism and Personalized Medicine-Application in Metabolic Syndrome
International Journal of Diabetes and Endocrinology
Volume 2, Issue 2, June 2017, Pages: 26-29
Received: Feb. 24, 2017; Accepted: Apr. 1, 2017; Published: May 18, 2017
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Authors
Ri-Hyang Paek, Pyongyang Medical College, Kim Il Sung University, Pyongyang, Democratic People’s Republic of Korea
Dae-Yong Jon, Pyongyang Medical College, Kim Il Sung University, Pyongyang, Democratic People’s Republic of Korea
Hak-Chol Ri, Pyongyang Medical College, Kim Il Sung University, Pyongyang, Democratic People’s Republic of KoreaPyongyang Medical College, Kim Il Sung University, Pyongyang, Democratic People’s Republic of Korea
Yong-Ju Gong, Pyongyang Medical College, Kim Il Sung University, Pyongyang, Democratic People’s Republic of Korea
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Abstract
To explore the associations between the phenotypes of metabolic syndrome and several genetic polymorphisms in the people of the Democratic People’s Republic of Korea, and to address the basic and practical problems that arise in carrying out the personalized medicine of metabolic syndrome. We analyzed the four phenotypes of metabolic syndrome including hypertension, dyslipidemia, diabetes mellitus and obesity by PCR. And we could select six genetic polymorphisms that are associated with more than three phenotypes (3 of 4 phenotypes including hypertension, dyslipidemia, diabetes mellitus and obesity) of metabolic syndrome; they are CMA (Chymase) A (-1903)G, GNB3(β3 subunit of G protein) C825T and C1429T, eNOS (Nitric oxide synthetase in the endothelium) 4a/4b and G894T, and MTHFR (Methylenetetra hydrofolate reductase) C677T. It shows that these can be the significant markers related with metabolic syndrome in the future. (It recommends future studies to support our conclusion) The typical genes associated with metabolic syndrome in the people of the Democratic People’s Republic of Korea will be basic data for the personalized medicine in metabolic syndrome.
Keywords
Metabolic Syndrome, Genes, Personalized Medicine, Polymorphism
To cite this article
Ri-Hyang Paek, Dae-Yong Jon, Hak-Chol Ri, Yong-Ju Gong, Genetic Polymorphism and Personalized Medicine-Application in Metabolic Syndrome, International Journal of Diabetes and Endocrinology. Vol. 2, No. 2, 2017, pp. 26-29. doi: 10.11648/j.ijde.20170202.12
Copyright
Copyright © 2017 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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