Insomnia, Fatigue, and Some Associated Factors Among Patients with Type 2 Diabetes Mellitus, Tabuk, Saudi Arabia
International Journal of Diabetes and Endocrinology
Volume 2, Issue 1, March 2017, Pages: 15-18
Received: Feb. 17, 2017; Accepted: Mar. 14, 2017; Published: Mar. 27, 2017
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Hyder Osman Mirghani, Medical Department, Faculty of Medicine, University of Tabuk, Tabuk, Kingdom of Saudi Arabia
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Both the quantity and quality of sleep are associated with type 2 diabetes mellitus; sleep has emerged as a novel target for prevention. In the current study, we aimed to assess insomnia and fatigue among patients with type 2 diabetes in Tabuk City, Saudi Arabia. A cross-sectional study conducted among 246 patients with type 2 diabetes during the period from March 2015 to June 2015, they were selected randomly from a diabetes center in Tabuk. Participants were invited to sign a written informed consent, then interviewed using a structured questionnaire based on socio-demographic data, failure to initiate and maintain sleep, non-restorative sleep, and fatigue. The Statistical Package for Social Sciences was used for data analysis; the Chi-square and Pearson correlation were used to test the statistical significance. Out of 246 patients with type 2 diabetes (54.1% females), aged 46.9±11.6 years, fatigue was evident in 23.5%. A significant statistical difference was observed in the HbA1C regarding failure to maintain sleep and duration of sleep P<0.05. No differences in the glycated hemoglobin regarding age, sex, duration of sleep, snoring, cough, dyspnea, failure to maintain sleep, and non-restorative sleep P>0.05. In conclusion: Patients with poor diabetes control had the failure to maintain sleep and longer duration of diabetes. Measures to implement good sleep hygiene among patients with type 2 diabetes are highly needed.
Insomnia, Fatigue, Type 2 Diabetes, Saudi Arabia
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Hyder Osman Mirghani, Insomnia, Fatigue, and Some Associated Factors Among Patients with Type 2 Diabetes Mellitus, Tabuk, Saudi Arabia, International Journal of Diabetes and Endocrinology. Vol. 2, No. 1, 2017, pp. 15-18. doi: 10.11648/j.ijde.20170201.14
Copyright © 2017 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License ( which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
International Diabetes Federation, Middle East, and North Africa 2015.
Khuwaja AK, Lalani S, Dhanani R, Azam IS, Rafique G, White F. Anxiety and depression among outpatients with type 2 diabetes: A multi-centre study of prevalence and associated factors. DiabetolMetabSyndr. 2010 Dec 20; 2: 72. doi: 10.1186/1758-5996-2-72.
Fritschi, C., Quinn, L. Fatigue in patients with diabetes: a review. J. Psychosom. Res. 2010; 69: 33–41.
Lasselin J, Layé S, Dexpert S, Aubert A, Gonzalez C, Gin H, Capuron L. Fatigue symptoms relate to systemic inflammation in patients with type 2 diabetes. Brain Behav Immun. 2012 Nov; 26 (8): 1211-9. doi: 10.1016/j.bbi.2012.03.003. Epub 2012 Mar 25.
Martine M. G, Cees JT, Elles S, Lotte B, Ellen B, and Hans K. Chronic Fatigue in Type 1 Diabetes: Highly Prevalent but Not Explained By Hyperglycemia or Glucose Variability. Diabetes Care 2014; 37: 74.
Fukuda K, Straus SE, Hickie I, Sharpe MC, Dobbins JG, Komaroff A; International Chronic Fatigue Syndrome Study Group. The chronic fatigue syndrome: a comprehensive approach to its definition and study. Ann Intern Med 1994; 121: 953–959.
Reeves WC, Lloyd A, Vernon SD, et al.; International Chronic Fatigue Syndrome Study Group. Identification of ambiguities in the 1994 chronic fatigue syndrome research case definition and recommendations for resolution. BMC Health Serv Res 2003; 3: 25.
Weijman I, Ros WJ, Rutten GE, SchaufeliWB, Schabracq MJ, Winnubst JA. Frequency and perceived burden of diabetes self-management activities in employees with insulin-treated diabetes: relationships with health outcomes. Diabetes Res Clin Pract. 2005; 68: 56–64.
Hewlett S, Chalder T, Choy E, et al. Fatigue in rheumatoid arthritis: time for a conceptual model. Rheumatology (Oxford) 2011; 50: 1004–1006.
Witte KK, Clark AL. Dyspnoea versus fatigue: additional prognostic information from symptoms in chronic heart failure? Eur J Heart Fail. 2008 Dec; 10 (12): 1224-8. doi: 10.1016/j.ejheart.2008.09.017. Epub 2008 Nov 7.
Sudore RL, Karter AJ, Huang ES, Moffet HH, Laiteerapong N, Schenker Y, Adams A, Whitmer RA, Liu JY, Miao Y, John PM, Schillinger D. Symptom burden of adults with type 2 diabetes across the disease course: diabetes & aging study. J Gen Intern Med. 2012 Dec; 27 (12): 1674-81. doi: 10.1007/s11606-012-2132-3. Epub 2012 Aug 2.
Phillips B, Hening W, Britz P, Mannino D. Prevalence, and cor¬relates of restless legs syndrome: results from the 2005 National Sleep Foundation Poll. Chest 2006; 129: 76-80.
Spiegel K, Leproult R, Van Cauter E: Impact of sleep debt on metabolic and endocrine function. Lancet 354: 1435–1439, 1999.
Johns MW. A new method for measuring daytime sleepiness; The Epworth sleepiness scale. Sleep 1999; 14: 540-545.
Scheen AJ, Van Cauter E. The roles of time of day and sleep quality in modulating glucose regulation: clinical implications. Horm Res 1998, 49: 191-201.
Vgontzas AN, Papanicolaou DA, Bixler EO, et al. Sleep apnea and daytime sleepiness and fatigue: relation to visceral obesity, insulin resistance, and hypercytokinemia. J ClinEndocrinolMetab 2000, 85: 1151-8.
[Mirghan HO, Elbadawi AS, Ahmed MA. The daytime sleepiness, snoring, and sleep duration effects on patients with type 2 diabetes; A case- control studyIndian Journal of Basic and Applied Medical Research; 2016: 5 (2): 464-470.
Konen JC, Curtis LG, Summerson JH. Symptoms and complications of adult diabetic patients in a family practice. rch Fam Med. 1996 Mar; 5 (3): 135-45.
Jain A, Sharma R, Choudhary PK, Yadav N, Jain G, Maanju M. Study of fatigue, depression, and associated factors in type 2 diabetes mellitus in industrial workers. Ind Psychiatry J. 2015 Jul-Dec; 24 (2): 179-84. doi: 10.4103/0972-6748.181731.
Lewis PE, Emasealu OV, Rohrbeck P, Hu Z. Risk of type II diabetes and hypertension associated with chronic insomnia among active component, U.S. Armed Forces, 1998-2013. MSMR. 2014 Oct; 21 (10): 6-13.
Cespedes EM, Dudley KA, Sotres-Alvarez D, Zee PC, Daviglus ML, Shah NA, Talavera GA, Gallo LC, Mattei J, Qi Q, Ramos AR, Schneiderman N, Espinoza-Giacinto RA, Patel SR. Joint associations of insomnia and sleep duration with prevalent diabetes: The Hispanic Community Health Study/Study of Latinos (HCHS/SOL). J Diabetes. 2016 May; 8 (3): 387-97. doi: 10.1111/1753-0407.12308. Epub 2015 Jul 21.
Cappuccio FP, D'Elia L, Strazzullo P, Miller MA. Quantity and quality of sleep and incidence of type 2 diabetes: a systematic review and meta-analysis. Diabetes Care. 2010 Feb; 33 (2): 414-20. doi: 10.2337/dc09-1124. Epub 2009 Nov 12.
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