Clinicopathological and Survival Pattern in Lung Cancer Patients of Different Age Group
International Journal of Clinical Oncology and Cancer Research
Volume 3, Issue 3, June 2018, Pages: 25-29
Received: Jun. 12, 2018;
Accepted: Jul. 1, 2018;
Published: Jul. 26, 2018
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Yumkhaibam Sobita Devi, Department of Radiotherapy, Regional Cancer Centre, Regional Institute of medical Science, Imphal, India
Srigopal Mohanty, Department of Radiotherapy, Regional Cancer Centre, Regional Institute of medical Science, Imphal, India
Laishram Jaichand Singh, Department of Radiotherapy, Regional Cancer Centre, Regional Institute of medical Science, Imphal, India
Daffilyne Lyngdoh Nongrum, Department of Radiotherapy, Regional Cancer Centre, Regional Institute of medical Science, Imphal, India
Lung cancer is considered as disease of older population with median age of 70 year at diagnosis. The aim of this study was to investigate the clinicopathological and survival pattern in younger and older age lung cancer patients. A retrospective study was carried out for all histopathologically or cytologically confirmed cases of primary lung cancer treated between 2011 and 2015at the Regional Cancer Centre, Imphal, Manipur, India. Cases were grouped into two age groups, i.e. the younger age group (<60 year) and the older age group (≥60 year).Out of the total 432cases of primary lung cancer, 124 were diagnosed at <60year of age with median age of 55 year and 308 patients were diagnosed at ≥60year of age with median age of 70year at diagnosis. Younger age group was found to have significantly lesser number of chronic smokers (p=0.000), lesser history of pulmonary tuberculosis (p=0.019), higher rate of adenocarcinoma (p=0.000), more positive family history (p=0.008), more advanced stage (III & IV) at presentation (p=0.000), greater proportion of patients undergone combined modality of treatment and lesser proportions of patients refused active cancer treatment (p=0.002) as compared to older age group. Response to treatment in terms of median survival (p=0.338) and three year overall survival (p=0.344) was found similar in both the age groups in spite of more advanced stage of the disease at presentation in younger age group, the reasons could be lesser proportion of older age patients got combined modality treatment due to greater comorbidities, poor performance status & greater proportion of older age patients refused active cancer treatment, because of lesser expectation in terms of long term benefit with treatment.
Yumkhaibam Sobita Devi,
Laishram Jaichand Singh,
Daffilyne Lyngdoh Nongrum,
Clinicopathological and Survival Pattern in Lung Cancer Patients of Different Age Group, International Journal of Clinical Oncology and Cancer Research.
Vol. 3, No. 3,
2018, pp. 25-29.
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