Effect of Mega Voltage Energy on Dose Enhancement in Phantom Study by Using Gold Nanoparticle Polymer Gel Dosimeter
International Journal of Biomedical Science and Engineering
Volume 3, Issue 1, February 2015, Pages: 1-4
Received: Nov. 29, 2014;
Accepted: Dec. 16, 2014;
Published: Jan. 20, 2015
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Gholamreza Atae , Babol University of Medical Science, paramedical school, Babol, Iran
Seyed Rabee Mahdavi , Iran University of Medical Science, Tehran, Iran
Akram Mohammadi Nokhandani , Babol University of Medical Science, paramedical school, Babol, Iran
Syede Mahsa Taheri Otaghsara , Babol University of Medical Science, paramedical school, Babol, Iran
Mahboubeh Khadem Abolfazli , Babol University of Medical Science, paramedical school, Babol, Iran
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Background: Polymer gels beam sensitive are valuable and confident for measurement of 3D dose distributions. One of the special features of this type of dosimeters is their tissue equivalence, which makes them appropriate for the investigation of dose enhancement with contrast agents with high atomic number. Objective: The purpose of this study is an investigating of dose enhancement dependent in energy within the gel medium with used of conformal distribution gold nanoparticle as contrast agents by high atomic number material. Methods: In this work, gold nanoparticles (GNPs) of 50nm diameter with 0.1m concentration embedded in gel and irradiated by different megavoltage energy of 18MVand 6MV photon beam. Then GN- MAGICA and MAGICA dose response curves compare and achieved dose enhancement. Results: Experimental results have shown dose enhancement factor of 6MV and 18MV in 0.1mM, concentration is 1.74 and 1.04 respectively. Conclusion: The results showed that by adding of gold nanoparticles to the MAGICA polymer gel absorbed dose is increased. The levels of polymerization of irradiated gels with and without AuNPs in energy 6MV is more than energy 18MV. It seems that because of the dominance of photoelectric effect at low energies and pair production effect at high energies.
Dose Enhancement, Polymer Gel Dosimeter, Gold Nanoparticles
To cite this article
Gholamreza Atae ,
Seyed Rabee Mahdavi ,
Akram Mohammadi Nokhandani ,
Syede Mahsa Taheri Otaghsara ,
Mahboubeh Khadem Abolfazli ,
Effect of Mega Voltage Energy on Dose Enhancement in Phantom Study by Using Gold Nanoparticle Polymer Gel Dosimeter, International Journal of Biomedical Science and Engineering.
Vol. 3, No. 1,
2015, pp. 1-4.
Burnet NG, Wurm R, Nyman J, Peacock JH (1996) Normal tissue radiosensitivity—How important is it? Clinc Oncol 8:25–34.
Raetorius NP, Mandal TK. Engineered nanoparticles in cancer therapy.Recent Pat Drug Deliv Formul2007;1:37–51
Mukherjee P, Bhattacharya R, Bone N, Lee YK, Patra CR, Wang S, et al. Potential therapeutic application of gold nanoparticles in B-chronic lymphocytic leukemia (BCLL): enhancing apoptosis.J Nanobiotechnol2007;5:4..
Rahman WN, Bishara N, Ackerly T, et al. Enhancement of radiation effects by gold nanoparticles for superficial radiation therapy.Nano-medicine2009;5:136-142.
Hainfeld JF, Slatkin DN, Smilowitz HM. The use of gold nanoparticles to enhance radiotherapy in mice.Phys Med Biol2004;49:N309-N315
Jain S, Coulter JA, Hounsell AR, et al. Cell-specific radiosensitization by gold nanoparticles at megavoltage radiation energies. Int J Radiat Oncol Biol Phys2011;79:531-539.
Baldock C, De Deene Y, Doran S, et al. Polymer gel dosimetry. Phys Med Biol2010;55:R1-R63.
Doran SJ. The history and principles of chemical dosimetry for 3-D radiation fields: gels, polymers and plastics. Appl Radiat Isotopes 2009; 67:393-398.
Butterworth KT, Coulter JA, Jain S, et al. Evaluation of cytotoxicityand radiation enhancement using 1.9 nm gold particles: potentialapplication for cancer thpy. Nanotechnology 2010; 21: 295101.
Chithrani DB, Jelveh S, Jalali F, et al. Gold nanoparticles as radiation sensitizers in cancer therapy. Radiat Res2010; 173:719-728.
Rahman WN, Bishara N, Ackerly T, et al. Enhancement of radiationeffects by gold nanoparticles for superficial radiation therapy.Nano-medicine2009;5:136-142.
Zahmatkesh MH, Kousari R, Akhlaghpour S, Bagheri SA (2004) MRI gel dosimetry with methacrylic acid, ascor‐bic acid, hydroquinon and copper in agarose (MAGICA) gel. In: Preliminary Proceedings of DOSGEL 2004; Ghent, Belgium.
Gustavsson H (2004) Radiotherapy gel dosimetry, development and application of normoxic polymer gels, [Ph.D Thesis], Malmo University Hospital, Lund University, Lund, Sweden