Mesenchymal Stem Cell Therapy for Breast Cancer: Challenges Remaining
International Journal of Biomedical Science and Engineering
Volume 2, Issue 6-1, December 2014, Pages: 20-24
Received: Jul. 19, 2014; Accepted: Dec. 19, 2014; Published: Jan. 27, 2015
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Authors
Armel Herve Nwabo Kamdje, Department of Biomedical Sciences, University of Ngaoundere, PO Box 454, Ngaoundere-Cameroon
Paul Faustin Seke Etet, Department of Basic Health Sciences, College of Applied Medical Sciences, Qassim University, Buraydah, 51452, Al-Qaseem, Saudi Arabia
Kiven Erique Lukong, Department of Biochemistry College of Medicine Room 4D30.5 Health Sciences Bldg University of Saskatchewan, 107 Wiggins Road Saskatoon, SK. S7N 5E5 Canada
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Abstract
The treatment of breast cancer, the most common malignancy among women worldwide, remains puzzling partly due to the resistance to therapeutics, which associates with the heterogeneity of case clinical presentations, and limits in the current understanding of the pathogenesis of solid cancers. Notably, it remains unclear: (i) whether breast cancer starts strictly as a local disease before metastasizing to the lymph nodes and distant organs, i.e. if cancer initiating cells are local cells that have undergone epithelial to mesenchymal transition; (ii) or if breast cancer is intrinsically a systemic disease started by malfunctioning circulating mesenchymal stem cells (MSCs) infiltrating the breast stroma to start tumorigenesis. Such limits in our understanding of breast cancer biology have been slowing the development of MSC-based therapies exploiting the ability of these cells to home into tumorigenic sites, kill cancer cells, stop neoangiogenesis, and repair damaged tissues, as well as therapeutic approaches using these cells as vehicle for gene therapy and for delivering anticancer therapeutics, which are potential game changing therapeutic approaches, particularly in currently incurable cancers and intractable cases. Major drawbacks to MSC-based therapy implementation and use in breast cancer are herein briefly discussed.
Keywords
Stem Cells, Breast Cancer, Microenvironment, Signaling Pathways, Therapy, Therapeutic Resistance
To cite this article
Armel Herve Nwabo Kamdje, Paul Faustin Seke Etet, Kiven Erique Lukong, Mesenchymal Stem Cell Therapy for Breast Cancer: Challenges Remaining, International Journal of Biomedical Science and Engineering. Special Issue: Cancer Research. Vol. 2, No. 6-1, 2014, pp. 20-24. doi: 10.11648/j.ijbse.s.2014020601.13
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