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Recent Advances in Stem Cell Therapy for Myelodysplastic Syndromes
International Journal of Biomedical Science and Engineering
Volume 2, Issue 6-1, December 2014, Pages: 1-6
Received: Jul. 19, 2014; Accepted: Oct. 17, 2014; Published: Nov. 5, 2014
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Armel Herve Nwabo Kamdje, Department of Biomedical Sciences, University of Ngaoundere, Ngaoundere, Cameroon
Paul Faustin Seke Etet, Department of Basic Health Sciences, College of Applied Medical Sciences, Qassim University, Buraydah, 51452, Saudi Arabia
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Many reports have emphasized the potential of stem/progenitor cells as intervention strategy to repair damaged tissue, providing new hope for the treatment of various diseases and conditions previously intractable like myelodysplastic syndromes, clonal hematopoietic disorders where blood-forming cells are damaged in the bone marrow. Early experimental evidence and growing clinical evidence strongly suggest that transplantation of allogeneic hematopoietic stem cells can repair the bone marrow and even cure myelodysplastic syndromes, with a reduced risk of rejection and manageable side effects. These findings have opened new avenues for cell-based cancer therapies, which have been providing very encouraging results in myelodysplastic syndromes and a number of blood cancers. However, though relatively minimal toxicity is reported in young adult patients, allogeneic stem cell transplantation still associates with life threatening undesired effects in pediatric and senior patients. In addition, a considerable fraction of these patients may also develop graft-versus-host disease. Recent advances in allogeneic stem cell transplantation in myelodysplastic syndrome as therapeutic strategy are herein briefly discussed, as well as newly proposed strategies to overcome the drawbacks of this technique.
Stem Cells, Myelodysplastic Syndrome, Microenvironment, Signaling Pathways, Therapy
To cite this article
Armel Herve Nwabo Kamdje, Paul Faustin Seke Etet, Recent Advances in Stem Cell Therapy for Myelodysplastic Syndromes, International Journal of Biomedical Science and Engineering. Special Issue: Cancer Research. Vol. 2, No. 6-1, 2014, pp. 1-6. doi: 10.11648/j.ijbse.s.2014020601.11
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