Numerical Simulation of Transport and Deposition of Dust Particles in Human Tracheobronchial Airways
Dust is a common pollutant of the air we breath. If dust particles are inhaled and deposited in human airways, they can cause a variety of respiratory disorders. The inhaled dust particles motion in human airways goes along with the airflow. The transport process can be considered as a two-phase flow of a gas phase and a particle phase. In this study, we investigated the airflow and dust particles transport and deposition in human tracheobronchial airways using computational fluid dynamics (CFD) techniques. A steady simulation was performed in asymmetric tracheobronchial airway mode consisting of 19 outlets to observe the characteristics of airflow fields. The discrete phase model (DPM) was employed to predict the particle trajectories and deposition in the airway model. Deposition resulted from inertial impaction and gravitational sedimentation was considered. In the simulation, the airflow characteristics differences in the right and left bronchial trees were observed. The influence of secondary flow on dust particles motion was great. More dust particles were deposited in the right bronchial tree than in the left. The deposition fraction of dust particles in human tracheobronchial airways was high. This study can provide awareness on deposition of dust particles passing beyond the larynx and enhance prevention of their entry into the respiratory system. It can also contribute a convenient way on the location of deposition of particles of a given type in human respiratory tract to be used for respiratory disease preventions.
Endalew Getnet Tsega,
Vinod Kumar Katiyar,
Numerical Simulation of Transport and Deposition of Dust Particles in Human Tracheobronchial Airways, International Journal of Biomedical Science and Engineering.
Vol. 7, No. 1,
2019, pp. 8-15.
Finucane, E. W., 1998. Concise Guide to Environmental Definitions, Conversions, and Formulae. CRC Press/Lewis, Boca Raton, FL.
Khan, R. K., Strand, M. A. (2018). Road dust and its effect on human health: a literature review. Epidemiology and health, 40, e2018013. doi:10.4178/epih.e2018013.
Nowak, N., Kakade, P. P, Annapragada, A. V. 2003. Computational fluid dynamics simulation of airflow and aerosol deposition in human lungs. Annals Biomedical Engineering 31, 374–390.
Ma, B., Lutchen, K. R., 2008. CFD simulation of aerosol deposition in an anatomically based human large–medium airway model. Annals of Biomedical Engineering 37, 271–285
Rahimi-Gorji, M., Gorji, T. B., Gorji-Bandpy, M., 2016. Details of regional particle deposition and airflow structures in a realistic model of human tracheobronchial airways: two-phase flow simulation. Computers in Biology and Medicine 74, 1–17.
Chen, X., Feng, Y., Zhong, W., Sun, B., Tao, F., 2018. Numerical investigation of particle deposition in a triple bifurcation airway due to gravitational sedimentation and inertial impaction. Powder Technology 323, 284– 293.
Zhang, B., Qi, S., Yue, Y., Shen, J., Li, C., Qian, W., Wu, J., 2018. Particle Disposition in the Realistic Airway Tree Models of Subjects with Tracheal Bronchus and COPD. BioMed Research International 2018, https://doi.org/10.1155/2018/7428609.
Zhang, Z. Kleinstreuer, C., Hyun, S. 2012. Size-change and deposition of conventional and composite cigarette smoke particles during inhalation in a subject-specific airway model. Journal of Aerosol Science 46, 34–52.
Augusto, L. L. X., Lopes, G. C., Gonçalves, J. A. S. (2016). A CFD study of deposition of pharmaceutical aerosols under different respiratory conditions. Brazilian Journal of Chemical Engineering. Brazilian Journal of Chemical Engineering, 33, 3, doi: 10.1590/0104-6632.20160333s20150100.
Tian, Z. F., Inthavong, K., Tu, J. Y., 2007. Deposition of Inhaled Wood Dust in the Nasal Cavity. Inhalation Toxicology 19, 1155–1165.
Zhou, Y., Su, W. C., Cheng, Y. S. 2008. Fiber deposition in the tracheobronchial region: Deposition equations. Inhalation Toxicology 20, 1191–1198.
Chen, W., Liu, Y., Huang, X., Rong, Y., 2012. Respiratory diseases among dust exposed workers, respiratory diseases. In Techopen, Doi: 10:5772
Esmaeil, N., Gharagozloo, M., Rezaei, A., Grunig, G. (2014). Dust events, pulmonary diseases and immune system. American journal of clinical and experimental immunology, 3 (1), 20-9.
Meo, S. A, Al-Drees, A. M., Al Masri, A. A., Al Rouq, F., Azeem, M. A.., 2013. Effect of duration of exposure to cement dust on respiratory function of non-smoking cement mill workers. International Journal of Environmental Research and Public. Health 10, 390–398.
Karkhanis, V., Joshi, J. M., 2011. Cement dust exposure-related emphysema in a construction worker. Lung India 28, 294–296.
Nordby, K. C., Fell, A. K. M., Noto, H., Eduard, W., Skogstad, M., Thomassen, Y., Bergamaschi, A., Kongerud, J., Kjuus, H., 2011. Exposure to thoracic dust, airway symptoms and lung function in cementproduction workers. European Respiratory Journal 38, 1278–1286.
Zeleke, Z. K., Moen, B. E., Bratveit, M., 2010. Cement dust exposure and acute lung function: A cross shift study. BMC Pulmonary Medicine 10: 19, doi: 10.1186/1471- 2466-10-19.
Tegen, I., 1994. Modeling of mineral dust in the atmosphere' sources, transport, and optical thickness. Journal of Geophysical Research, 99, 22897-22914.
Pepper, I. L., Gerba, C. P., Brusseau, M. L., 2011. Environmental and Pollution Science. Second Edition, Elsevier.
Hayden, J. A. 1997. Measuring plutonium concentrations in respirable dust. Science, 196 (4294), 1126.
Gardiner, K., Harrington, J. M., 2005. Occupational Hygiene. 2005. Third edition, Blackwell publishing Inc., Malden, Massachusetts, USA.
Brown, J., Gordon, T., Price, O., Asgharian, B., 2013. Thoracic and respirable particle definitions for human health risk assessment. Particle and Fibre Toxicology 10 (1):12, DOI: 10.1186/1743-8977-10-12.
Le Blond, J. S., Woskie, S., Horwell, C. J., Williamson, B. J., 2017. Particulate matter produced during commercial sugarcane harvesting and processing: A respiratory health hazard? Atmospheric Environment 149, 34-46.
Choi, J. 2011. Multiscale numerical analysis of airflow in CT-based subject specific breathing human lungs. PhD thesis, University of Iowa, http://ir.uiowa.edu/etd/2685.
Horsfeld, K., Dart, G., Olson, D. E., Filley, G. F. Cumming, G. 1971 Models of the human bronchial tree. Journal of Applied Physiology 31, 207-217.
Hegedus, C. J, Balasha, Z. Y. I, Farkas, Á. 2004. Detailed mathematical description of the geometry of airway bifurcations. Respiratory Physiology & Neurobiology 141, 99−114.
Gemci, T., Ponyavin, V., Chen, Y., Chen, H., Collins, R., 2008. Computational model of airflow in upper 17 generations of human respiratory tract, Journal of Biomechanics 41, 2047–2054.
Zhang, Z., Kleinstreuer, C. and Kim, C. 2002. Gas–solid two-phase flow in a triple bifurcation lung airway model. Int. J. Multiphase Flow 28: 1021–1046
Elcner, J, Lizal F, Jedelsky J, Jicha M, Chovancova M (2016) Numerical investigation of inspiratory airflow in a realistic model of the human tracheobronchial airways and a comparison with experimental results. Biomechanics and Modeling in Mechanobiology 15, 447–469.
Gardiner, K., Harrington, J. M., 2005. Occupational Hygiene. Third Edition, Blackwell publishing Ltd, USA.
Morsi, S. A., Alexander, A. J., 1972. An investigation of particle trajectories in two- phase flow systems. Journal of Fluid Mechanics, 55, 193–208.
Kleinstreuer, Clement, 2018. Modern Fluid Dynamics. Second Edition, Modern Fluid Dynamics, Second Edition, CRC Press, Boca Raton, FL
de Rochefort, L., Vial, L., Fodil, R., Maître, X., Louis, B., Isabey, D., Caillibotte, G., Thiriet, M., Bittoun, J., Durand, E., Sbirlea-Apiou, G., 2007. In vitro validation of computational fluid dynamic simulation in human proximal airways with hyperpolarized 3He magnetic resonance phase-contrast velocimetry. Journal of Applied Physiology 102, 2012–2023.
Qi, S., Zhang, B., Teng, Y., Li, J., Yue, Y., Kang, Y., Qian, W., 2017. Transient Dynamics Simulation of Airflow in a CT-Scanned Human Airway Tree: More or Fewer Terminal Bronchi? Computational and Mathematical Methods in Medicine 2017, Article ID 1969023 https://doi.org/10.1155/2017/1969023.
Ibrahim, I. B. M., Aghasafari, P., Pidaparti, R. M., 2016. Transient mechanical response of lung airway tissue during mechanical ventilation. Bioengineering 2016, 3, 4; doi: 10.3390/bioengineering3010004.
Zhang, B., Qi, S., Yue, Y., Shen, J., Li, C., Qian, W., Wu, J., 2018. Particle Disposition in the realistic airway tree models of subjects with Tracheal Bronchus and COPD. BioMed research international 2018, 7428609.
Rahimi-Gorji, M., Pourmehran, O. Gorji-Bandpy, M., Gorji, T. B., 2015. CFD simulation of airflow behavior and particle transport and deposition in different breathing conditions through the realistic model of human airways. Journal of Molecular Liquids 209, 121-133.
Ou, C., Li Y, Wei, J., Yen H. L., Deng, Q., 2017. Numerical modeling of particle deposition in ferret airways: A comparison with humans. Aerosol Science and Technology 51, 477-487.