Stability-Indicating HPLC Method for the Simultaneous Determination of Paracetamol and Tramadol Hydrochloride in Fixed-Dose Combination Tablets
International Journal of Biomedical Science and Engineering
Volume 5, Issue 4, August 2017, Pages: 41-47
Received: Oct. 17, 2017;
Accepted: Oct. 31, 2017;
Published: Nov. 29, 2017
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Monica Mame Soma Nyansa, Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana
Patrick Doe Fiawoyife, Manufacturing Division, Ernest Chemists Limited, Tema, Ghana
Nana Ama Mireku-Gyimah, Department of Pharmacognosy, Faculty of Pharmacy and Pharmaceutical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana
John Nii Adotey Addotey, Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana
Monica Mame Soma Nyansa,
Patrick Doe Fiawoyife,
Nana Ama Mireku-Gyimah,
John Nii Adotey Addotey,
Stability-Indicating HPLC Method for the Simultaneous Determination of Paracetamol and Tramadol Hydrochloride in Fixed-Dose Combination Tablets, International Journal of Biomedical Science and Engineering.
Vol. 5, No. 4,
2017, pp. 41-47.
Copyright © 2017 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/
) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
P. Hamrapurkar, P. Patil, M. Desai, M. Phale, S. Pawar, “Stress degradation studies and development of a validated stability-indicating-assay-method for determination of diacerein in presence of degradation products,” Pharm Methods, vol. 2 (1), pp. 30-35, Jan 2011.
ICH Harmonised Tripartite Guideline (2003). Stability Testing of New Drug Substances and Products (Q1AR2).
U. S. Food and Drug Administration (2017). Combination Products.
S. Bangalore, G. Kamalakkannan, S. Parkar and F. H. Messerli, “Fixed-Dose combinations improve medication compliance: A Meta-Analysis,” Am J Med, vol. 120 (8), pp. 713-719, August 2007.
British Pharmacopeia Commission, The British Pharmacopoeia 2013. London: The Stationery Office.
S. Dhillon, “Tramadol/Paracetamol Fixed-Dose Combination; A review of its use in the management of moderate to severe pain,” Clin Drug Investig, vol. 30 (10), pp. 711-738, 2010.
S. S. Reuben, “Perioperative use of COX-2 agents,” in Current Therapy in Pain, 1st edn. H. Smith, Eds. Philadelphia: Saunders Elsevier, 2009, pp. 60-62.
F. Ghorbani-Bidkorbeh, S. Shakrokhian, A. Mohammadi, R. Dinavard, “Simultaneous voltammetric determination of tramadol and acetaminophen using carbon nanoparticles modified glassy electrode,” Electrochimica Acta, vol. 55 (8), pp. 2752-2759, March 2010.
D. Ravisankar, V. Sridevi, P. G. Kumari, “Development and validation of HPLC method for the simultaneous quantification of acetaminophen and tramadol in combined pharmaceutical dosage forms with UV detection,” International Journal of Applied Biology and Pharmaceutical Technology, vol. 6 (2), pp. 174-181, April 2015.
M. V. V. N. M. Krishna, S. V. Rao, N. V. S. Venugopal, B. P. V. Mantena, “Simultaneous determination of acetaminophen and tramadol impurities in combination product of acetaminophen and tramadol tablets by UPLC with trifunctional octadecyl column,” TACL, vol. 5, pp. 306-318, 2015.
R. M. Kamble, S. Singh, “Stability-indicating RP-HPLC method for analysis of paracetamol and tramadol in a pharmaceutical dosage form,” E-Journal of Chemistry, vol. 9 (3), 1347-1356, 2012.
K. Karunakaran, G. Navaneethan, K. P. Elango, “Development and validation of a stability-indicating RP-HPLC method for simultaneous determination of paracetamol, tramadol HCl and domperidone in a combined dosage form,” Trop J Pharm Res, vol. 11 (1), pp. 99-106, March 2012.
ICH Harmonised Tripartite Guideline (1996). Validation of Analytical Procedures: Text and Methodology Q2 (R1).
A. Bose, ‘HPLC calibration process parameters in terms of system suitability test,” Austin chromatogr, vol. 1 (2), pp. 4, 2014.